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Index > Protein center > Scn8a(Gene name) > Rat
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  • Scn8a (Gene name),
  • Sodium channel protein type 8 subunit alpha (Protein name ),  SCN8A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Scn8a;
    Protein name:
    Sodium channel protein type 8 subunit alpha;
    Alternative:
    Sodium channel 6(NaCh6);Peripheral nerve protein type 4(PN4);Voltage-gated sodium channel subunit alpha Nav1.6;Sodium channel protein type VIII subunit alpha;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with NEDD4 and NEDD4L.
    Function:
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1978
    Sequence:
    50:
    MAARLLAPPG | PDSFKPFTPE | SLANIERRIA | ESKLKKPPKA | DGSHREDDED | 
    100:
    SKPKPNSDLE | AGKSLPFIYG | DIPQGLVAVP | LEDFDPYYLT | QKTFVVLNRG | 
    150:
    KTLFRFSATP | ALYILSPFNL | IRRIAIKILI | HSVFSMIIMC | TILTNCVFMT | 
    200:
    FSNPPEWSKN | VEYTFTGIYT | FESLVKIIAR | GFCIDGFTFL | RDPWNWLDFS | 
    250:
    VIMMAYVTEF | VDLGNVSALR | TFRVLRALKT | ISVIPGLKTI | VGALIQSVKK | 
    300:
    LSDVMILTVF | CLSVFALIGL | QLFMGNLRNK | CVVWPINFNE | SYLENGTRGF | 
    350:
    DWEEYINNKT | NFYMVPGMLE | PLLCGNSSDA | GQCPEGFQCM | KAGRNPNYGY | 
    400:
    TSFDTFSWAF | LALFRLMTQD | YWENLYQLTL | RAAGKTYMIF | FVLVIFVGSF | 
    450:
    YLVNLILAVV | AMAYEEQNQA | TLEEAEQKEA | EFKAMLEQLK | KQQEEAQAAA | 
    500:
    MATSAGTVSE | DAIEEEGEDG | VGSPRSSSEL | SKLSSKSAKE | RRNRRKKRKQ | 
    550:
    KELSEGEEKG | DPEKVFKSES | EDGMRRKAFR | LPDNRIGRKF | SIMNQSLLSI | 
    600:
    PGSPFLSRHN | SKSSIFSFRG | PGRFRDPGSE | NEFADDEHST | VEESEGRRDS | 
    650:
    LFIPIRARER | RSSYSGYSGY | SQCSRSSRIF | PSLRRSVKRN | STVDCNGVVS | 
    700:
    LIGPGSHIGR | LLPEATTEVE | IKKKGPGSLL | VSMDQLASYG | RKDRINSIMS | 
    750:
    VVTNTLVEEL | EESQRKCPPC | WYKFANTFLI | WECHPYWIKL | KEIVNLIVMD | 
    800:
    PFVDLAITIC | IVLNTLFMAM | EHHPMTPQFE | HVLAVGNLVF | TGIFTAEMFL | 
    850:
    KLIAMDPYYY | FQEGWNIFDG | FIVSLSLMEL | SLADVEGLSV | LRSFRLLRVF | 
    900:
    KLAKSWPTLN | MLIKIIGNSV | GALGNLTLVL | AIIVFIFAVV | GMQLFGKSYK | 
    950:
    ECVCKINQEC | KLPRWHMNDF | FHSFLIVFRV | LCGEWIETMW | DCMEVAGQAM | 
    1000:
    CLIVFMMVMV | IGNLVVLNLF | LALLLSSFSA | DNLAATDDDG | EMNNLQISVI | 
    1050:
    RIKKGVAWTK | VKVHAFMQAH | FKQREADEVK | PLDELYEKKA | NCIANHTGVD | 
    1100:
    IHRNGDFQKN | GNGTTSGIGS | SVEKYIIDED | HMSFINNPNL | TVRVPIAVGE | 
    1150:
    SDFENLNTED | VSSESDPEGS | KDKLDDTSSS | EGSTIDIKPE | VEEVPVEQPE | 
    1200:
    EYLDPDACFT | EGCVQRFKCC | QVNIEEGLGK | SWWILRKTCF | LIVEHNWFET | 
    1250:
    FIIFMILLSS | GALAFEDIYI | EQRKTIRTIL | EYADKVFTYI | FILEMLLKWT | 
    1300:
    AYGFVKFFTN | AWCWLDFLIV | AVSLVSLIAN | ALGYSELGAI | KSLRTLRALR | 
    1350:
    PLRALSRFEG | MRVVVNALVG | AIPSIMNVLL | VCLIFWLIFS | IMGVNLFAGK | 
    1400:
    YHYCFNETSE | IRFEIDIVNN | KTDCEKLMEG | NSTEIRWKNV | KINFDNVGAG | 
    1450:
    YLALLQVATF | KGWMDIMYAA | VDSRKPDEQP | DYEGNIYMYI | YFVIFIIFGS | 
    1500:
    FFTLNLFIGV | IIDNFNQQKK | KFGGQDIFMT | EEQKKYYNAM | KKLGSKKPQK | 
    1550:
    PIPRPLNKIQ | GIVFDFVTQQ | AFDIVIMMLI | CLNMVTMMVE | TDTQSKQMEN | 
    1600:
    ILYWINLVFV | IFFTCECVLK | MFALRHYYFT | IGWNIFDFVV | VILSIVGMFL | 
    1650:
    ADIIEKYFVS | PTLFRVIRLA | RIGRILRLIK | GAKGIRTLLF | ALMMSLPALF | 
    1700:
    NIGLLLFLVM | FIFSIFGMSN | FAYVKHEAGI | DDMFNFETFG | NSMICLFQIT | 
    1750:
    TSAGWDGLLL | PILNRPPDCS | LDKEHPGSGF | KGDCGNPSVG | IFFFVSYIII | 
    1800:
    SFLIVVNMYI | AIILENFSVA | TEESADPLSE | DDFETFYEIW | EKFDPDATQF | 
    1850:
    IEYCKLADFA | DALEHPLRVP | KPNTIELIAM | DLPMVSGDRI | HCLDILFAFT | 
    1900:
    KRVLGDSGEL | DILRQQMEER | FVASNPSKVS | YEPITTTLRR | KQEEVSAVVL | 
    1950:
    QRAYRGHLAR | RGFICRKMAS | NKLENGGTHR | DKKESTPSTA | SLPSYDSVTK | 
    1978:
    PDKEKQQRAE | EGRRERAKRQ | KEVRESKC
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    E15346r
    Price:
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    Packing:
    96T
    ELISA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    E15346m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    E15346h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    U15346r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    U15346m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    U15346h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    P15346Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    P15346Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Cat.:
    P15346Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 8 subunit alpha
    Protein for Rat Sodium channel protein type 8 subunit alpha
    Protein for Rat Sodium channel protein type 8 subunit alpha
    Protein for Rat Sodium channel protein type 8 subunit alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia."
      Dietrich P.S. , McGivern J.G. , Delgado S.G. , Koch B.D. , Eglen R.M. , Hunter J.C. , Sangameswaran L.
      J. Neurochem.70:2262-2272(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
      tissue: Spinal ganglion.
    2. 2.
      "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons."
      Wittmack E.K. , Rush A.M. , Craner M.J. , Goldfarb M. , Waxman S.G. , Dib-Hajj S.D.
      J. Neurosci.24:6765-6775(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF13
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