SCN9A ELISA Kit for Human(Homo sapiens) | EIAab.comSCN9A ELISA Kit for Human(Homo sapiens)

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SCN9A (Gene name),

Sodium channel protein type 9 subunit alpha (Protein name ), SCN9A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SCN9A(NENA);

Protein name:

Sodium channel protein type 9 subunit alpha;

Alternative:

Peripheral sodium channel 1(PN1);Neuroendocrine sodium channel(hNE-Na);Voltage-gated sodium channel subunit alpha Nav1.7;Sodium channel protein type IX subunit alpha;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L.

Function:

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.

Subcellular Location:

Membrane Multi-pass membrane protein In neurite terminals.

Protein Attributes:

Sequence length:

1988

Sequence:

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1988:

STTSPPSYDS | VTKPDKEKYE | QDRTEKEDKG | KDSKESKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q15858

Pfam:

PF11933

MIM:

133020

SMR:

Q15858

KEGG:

hsa:6335

UniGene:

Hs.439145

Uniprot:

Q15858

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ELISA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

E15345h

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96T

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ELISA Kit for Human Sodium channel protein type 9 subunit alpha

MSDS:

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ELISA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

E15345m

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96T

ELISA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

E15345r

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96T

CLIA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

U15345r

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MSDS:

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Packing:

96T

CLIA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

U15345m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Sodium channel protein type 9 subunit alpha

MSDS:

Please sign in first.

CLIA Kit for Human Sodium channel protein type 9 subunit alpha

Cat.:

U15345h

Price:

Please sign in first.

MSDS:

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Packing:

96T

Polyclonal Antibody for Human Sodium channel protein type 9 subunit alpha

Cat.:

P15345Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Sodium channel protein type 9 subunit alpha

Cat.:

P15345Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Sodium channel protein type 9 subunit alpha

Cat.:

P15345Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Sodium channel protein type 9 subunit alpha

Protein for Human Sodium channel protein type 9 subunit alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells."
Klugbauer N. , Lacinova L. , Flockerzi V. , Hofmann F.
EMBO J.14:1084-1090(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION;TISSUE SPECIFICITY;VARIANT ARG-1161
tissue: Thyroid.
2.

"An SCN9A channelopathy causes congenital inability to experience pain."
Cox J.J. , Reimann F. , Nicholas A.K. , Thornton G. , Roberts E. , Springell K. , Karbani G. , Jafri H. , Mannan J. , Raashid Y. , Al-Gazali L. , Hamamy H. , Valente E.M. , Gorman S. , Williams R. , McHale D.P. , Wood J.N. , Gribble F.M. , more...
Nature444:894-898(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INVOLVEMENT IN CONGENITAL INSENSITIVITY TO PAIN;CHARACTERIZATION;VARIANT ARG-1161
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia."
Raymond C.K. , Castle J.C. , Garrett-Engele P.W. , Armour C.D. , Kan Z.G. , Tsinoremas N.T. , Johnson J.M.
J. Biol. Chem.279:46234-46241(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-674 (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
tissue: Spinal ganglion.
5.

"Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: correlative studies on cell lines and biopsy tissues."
Diss J.K.J. , Fraser S.P. , Coombes R.C. , Djamgoz M.B.A.
Submitted (2001-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-264 AND 1340-1400
6.

"Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia."
Yang Y. , Wang Y. , Li S. , Xu Z. , Li H. , Ma L. , Fan J. , Bu D. , Liu B. , Fan Z. , Wu G. , Jin J. , Ding B. , Zhu X. , Shen Y.
J. Med. Genet.41:171-174(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 840-958;VARIANTS PERYTHM THR-859 AND HIS-869
7.

"A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia."
Sangameswaran L. , Fish L.M. , Koch B.D. , Rabert D.K. , Delgado S.G. , Ilnicka M. , Jakeman L.B. , Novakovic S. , Wong K. , Sze P. , Tzoumaka E. , Stewart G.R. , Herman R.C. , Chan H. , Eglen R.M. , Hunter J.C.
J. Biol. Chem.272:14805-14809(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A."
Jo T. , Nagata T. , Iida H. , Imuta H. , Iwasawa K. , Ma J. , Hara K. , Omata M. , Nagai R. , Takizawa H. , Nagase T. , Nakajima T.
FEBS Lett.567:339-343(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION;TISSUE SPECIFICITY
9.

"Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy."
Cummins T.R. , Dib-Hajj S.D. , Waxman S.G.
J. Neurosci.24:8232-8236(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS PERYTHM THR-859 AND HIS-869
10.

"Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7."
Michiels J.J. , te Morsche R.H.M. , Jansen J.B.M.J. , Drenth J.P.H.
Arch. Neurol.62:1587-1590(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PERYTHM THR-241
11.

"Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons."
Dib-Hajj S.D. , Rush A.M. , Cummins T.R. , Hisama F.M. , Novella S. , Tyrrell L. , Marshall L. , Waxman S.G.
Brain128:1847-1854(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PERYTHM VAL-1460;CHARACTERIZATION OF VARIANT PERYTHM VAL-1460
12.

"SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels."
Drenth J.P. , te Morsche R.H. , Guillet G. , Taieb A. , Kirby R.L. , Jansen J.B.
J. Invest. Dermatol.124:1333-1338(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PERYTHM SER-216; LYS-395; THR-859 AND PHE-869;VARIANT ARG-1161
13.

"Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7."
Han C. , Rush A.M. , Dib-Hajj S.D. , Li S. , Xu Z. , Wang Y. , Tyrrell L. , Wang X. , Yang Y. , Waxman S.G.
Ann. Neurol.59:553-558(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PERYTHM PHE-869;CHARACTERIZATION OF VARIANT PERYTHM PHE-869
14.

"Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy."
Choi J.S. , Dib-Hajj S.D. , Waxman S.G.
Neurology67:1563-1567(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT PERYTHM SER-216
15.

"SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes."
Fertleman C.R. , Baker M.D. , Parker K.A. , Moffatt S. , Elmslie F.V. , Abrahamsen B. , Ostman J. , Klugbauer N. , Wood J.N. , Gardiner R.M. , Rees M.
Neuron52:767-774(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PEPD CYS-1007; PHE-1309; ASP-1309; PHE-1310; THR-1472; VAL-1473; ILE-1475 AND LYS-1638;CHARACTERIZATION OF VARIANTS PEPD THR-1472; ILE-1475 AND LYS-1638
16.

"A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons."
Rush A.M. , Dib-Hajj S.D. , Liu S. , Cummins T.R. , Black J.A. , Waxman S.G.
Proc. Natl. Acad. Sci. U.S.A.103:8245-8250(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT PERYTHM HIS-869
17.

"Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation."
Han C. , Dib-Hajj S.D. , Lin Z. , Li Y. , Eastman E.M. , Tyrrell L. , Cao X. , Yang Y. , Waxman S.G.
Brain132:1711-1722(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PERYTHM ARG-10;CHARACTERIZATION OF VARIANTS PERYTHM ARG-10 AND THR-859
18.

"A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome."
Singh N.A. , Pappas C. , Dahle E.J. , Claes L.R. , Pruess T.H. , De Jonghe P. , Thompson J. , Dixon M. , Gurnett C. , Peiffer A. , White H.S. , Filloux F. , Leppert M.F.
PLoS Genet.5:E1000649-E1000649(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GEFS+7 TYR-641 AND ARG-666;VARIANTS FEB3B VAL-62 AND GLN-149;VARIANTS MET-228; ASN-490; LYS-519; MET-695; TYR-710; VAL-750; PHE-1134; GLN-1171 AND VAL-1278
19.

"Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations."
Cox J.J. , Sheynin J. , Shorer Z. , Reimann F. , Nicholas A.K. , Zubovic L. , Baralle M. , Wraige E. , Manor E. , Levy J. , Woods C.G. , Parvari R.
Hum. Mutat.31:E1670-E1686(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CIPAR GLN-907 AND 1381-ARG--LEU-1385 DEL;CHARACTERIZATION OF VARIANTS CIPAR GLN-907 AND 1381-ARG--LEU-1385 DEL

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