Scavenger receptor class B member 1 (Protein name
), SCRB1_PIG from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
SCARB1;
Protein name:
Scavenger receptor class B member 1(SRB1);
Alternative:
SR-BI;High density lipoprotein receptor SR-BI;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
The C-terminal region binds to PDZK1.
Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Membrane
caveola
Multi-pass membrane protein
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
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Precision
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Recovery
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Linearity
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References
1.
"Characterization of porcine high density lipoprotein (HDL) receptor SR-BI." Kim J.G.
,
Vallet J.L.
,
Christenson R.K.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]