SDHA ELISA Kit for Human(Homo sapiens) | EIAab.comSDHA ELISA Kit for Human(Homo sapiens)

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SDHA (Gene name),

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Protein name ), SDHA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SDHA(SDH2;SDHF);

Protein name:

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;

Alternative:

Flavoprotein subunit of complex II(Fp);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment. Interacts with TRAP1.

Function:

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.

Subcellular Location:

Mitochondrion inner membrane Peripheral membrane protein Matrix side

Protein Attributes:

Sequence length:

664

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

664:

EADCATVPPA | IRSY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

252011

SMR:

P31040

KEGG:

hsa:6389

STRING:

9606.ENSP00000264932

UniGene:

Hs.440475

Pfam:

PF00890

Uniprot:

P31040

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ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270r

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ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270p

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270m

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270c

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ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270b

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270r

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270b

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270h

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270p

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270h

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270c

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96T

ELISA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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E14270m

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270h

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

U14270m

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270p

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270b

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270p

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270m

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270b

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270h

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CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270r

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CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270c

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CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270c

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96T

CLIA Kit for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

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U14270r

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Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Cat.:

P14270Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Protein for Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria."
Hirawake H. , Wang H. , Kuramochi T. , Kojima S. , Kita K.
J. Biochem.116:221-227(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase."
Morris A.A.M. , Farnsworth L. , Ackrell B.A.C. , Turnbull D.M. , Birch-MacHin M.A.
Biochim. Biophys. Acta1185:125-128(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PHE-629 AND ILE-657
tissue: Heart.
3.

"Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome."
Parfait B. , Chretien D. , Roetig A. , Marsac C. , Munnich A. , Rustin P.
Hum. Genet.106:236-243(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LS VAL-524
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT VAL-38
tissue: Substantia nigra.
tissue: Tongue.
5.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-629
tissue: Brain.
6.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT PHE-629
tissue: Colon.
tissue: Placenta.
9.

"Cloning of the flavoprotein subunit of human succinate dehydrogenase."
Malcovati M. , Marchetti L. , Zanelli E. , Tenchini M.L.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
10.

"Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency."
Bourgeron T. , Rustin P. , Chretien D. , Birch-MacHin M.A. , Bourgeois M. , Viegas-Pequignot E. , Munnich A. , Roetig A.
Nat. Genet.11:144-149(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 546-562;VARIANT LS TRP-554
11.

"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N. , Vainonen J.P. , Stralfors P. , Vener A.V.
Biochem. J.383:237-248(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 76-92 AND 398-418
tissue: Adipocyte.
12.

"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma."
Hao H.-X. , Khalimonchuk O. , Schraders M. , Dephoure N. , Bayley J.-P. , Kunst H. , Devilee P. , Cremers C.W.R.J. , Schiffman J.D. , Bentz B.G. , Gygi S.P. , Winge D.R. , Kremer H. , Rutter J.
Science325:1139-1142(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SDHAF2
13.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-179; LYS-335; LYS-541 AND LYS-608;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"SDHA is a tumor suppressor gene causing paraganglioma."
Burnichon N. , Briere J.J. , Libe R. , Vescovo L. , Riviere J. , Tissier F. , Jouanno E. , Jeunemaitre X. , Benit P. , Tzagoloff A. , Rustin P. , Bertherat J. , Favier J. , Gimenez-Roqueplo A.P.
Hum. Mol. Genet.19:3011-3020(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANT PGL5 TRP-589;CHARACTERIZATION OF VARIANT PGL5 TRP-589
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components."
Ogura M. , Yamaki J. , Homma M.K. , Homma Y.
Biochem. J.447:281-289(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-215
17.

"The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase."
Sciacovelli M. , Guzzo G. , Morello V. , Frezza C. , Zheng L. , Nannini N. , Calabrese F. , Laudiero G. , Esposito F. , Landriscina M. , Defilippi P. , Bernardi P. , Rasola A.
Cell Metab.17:988-999(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAP1
18.

"Homozygous Gly555Glu mutation in the nuclear-encoded 70 kDa flavoprotein gene causes instability of the respiratory chain complex II."
Van Coster R. , Seneca S. , Smet J. , Van Hecke R. , Gerlo E. , Devreese B. , Van Beeumen J. , Leroy J.G. , De Meirleir L. , Lissens W.
Am. J. Med. Genet. A120:13-18(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MT-C2D GLU-555
19.

"Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase."
Levitas A. , Muhammad E. , Harel G. , Saada A. , Caspi V.C. , Manor E. , Beck J.C. , Sheffield V. , Parvari R.
Eur. J. Hum. Genet.18:1160-1165(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1GG GLU-555

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