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Index > Protein center > SDHB(Gene name) > Human
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  • SDHB (Gene name),
  • Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Protein name ),  SDHB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    SDHB(SDH;SDH1);
    Protein name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;
    Alternative:
    Iron-sulfur subunit of complex II(Ip);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
    Function:
    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
    Subcellular Location:
    Mitochondrion inner membrane Peripheral membrane protein Matrix side
    Protein Attributes:
    Sequence length:
    280
    Sequence:
    50:
    MAAVVALSLR | RRLPATTLGG | ACLQASRGAQ | TAAATAPRIK | KFAIYRWDPD | 
    100:
    KAGDKPHMQT | YEVDLNKCGP | MVLDALIKIK | NEVDSTLTFR | RSCREGICGS | 
    150:
    CAMNINGGNT | LACTRRIDTN | LNKVSKIYPL | PHMYVIKDLV | PDLSNFYAQY | 
    200:
    KSIEPYLKKK | DESQEGKQQY | LQSIEEREKL | DGLYECILCA | CCSTSCPSYW | 
    250:
    WNGDKYLGPA | VLMQAYRWMI | DSRDDFTEER | LAKLQDPFSL | YRCHTIMNCT | 
    280:
    RTCPKGLNPG | KAIAEIKKMM | ATYKEKKASV | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

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    References
    1. 1.
      "Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase."
      Au H.C. , Ream-Robinson D. , Bellew L.A. , Broomfield P.L.E. , Saghbini M. , Scheffler I.E.
      Gene159:249-253(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M. , Nilsson M.A. , Arnason U. , Harley E.H. , Janke A.
      Mol. Biol. Evol.23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-264
    7. 7.
      "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria."
      Kita K. , Oya H. , Gennis R.B. , Ackrell B.A.C. , Kasahara M.
      Biochem. Biophys. Res. Commun.166:101-108(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-280
      tissue: Liver.
    8. 8.
      "Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species."
      Gould S.J. , Subramani S. , Scheffler I.E.
      Proc. Natl. Acad. Sci. U.S.A.86:1934-1938(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-249
      tissue: Fibroblast.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma."
      Astuti D. , Latif F. , Dallol A. , Dahia P.L.M. , Douglas F. , George E. , Skoeldberg F. , Husebye E.S. , Eng C. , Maher E.R.
      Am. J. Hum. Genet.69:49-54(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGL4 ARG-197;VARIANT PCC SER-87
    12. 12.
      "Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene."
      Young A.L. , Baysal B.E. , Deb A. , Young W.F. Jr.
      J. Clin. Endocrinol. Metab.87:4101-4105(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAMILIAL MALIGNANT PARAGANGLIOMA HIS-242
    13. 13.
      "Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas."
      Baysal B.E. , Willett-Brozick J.E. , Lawrence E.C. , Drovdlic C.M. , Savul S.A. , McLeod D.R. , Yee H.A. , Brackmann D.E. , Slattery W.H. III , Myers E.N. , Ferrell R.E. , Rubinstein W.S.
      J. Med. Genet.39:178-183(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGL4 ARG-131
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCC GLN-29 INS; GLY-46; TYR-101; ARG-192; TYR-196 AND HIS-242
    15. 15.
      "Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas."
      Gimenez-Roqueplo A.-P. , Favier J. , Rustin P. , Rieubland C. , Crespin M. , Nau V. , Khau Van Kien P. , Corvol P. , Plouin P.-F. , Jeunemaitre X.
      Cancer Res.63:5615-5621(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCC PRO-43; GLN-46; GLY-46 AND CYS-230
    16. 16.
      "Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility."
      Astuti D. , Hart-Holden N. , Latif F. , Lalloo F. , Black G.C. , Lim C. , Moran A. , Grossman A.B. , Hodgson S.V. , Freemont A. , Ramsden R. , Eng C. , Evans D.G.R. , Maher E.R.
      Clin. Endocrinol. (Oxf.)59:728-733(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCC ASN-127;VARIANT PGL4 ARG-197
    17. 17.
      "Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas."
      Benn D.E. , Croxson M.S. , Tucker K. , Bambach C.P. , Richardson A.L. , Delbridge L. , Pullan P.T. , Hammond J. , Marsh D.J. , Robinson B.G.
      Oncogene22:1358-1364(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCC GLN-46 AND HIS-65
    18. 18.
      "K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma."
      McDonnell C.M. , Benn D.E. , Marsh D.J. , Robinson B.G. , Zacharin M.R.
      Clin. Endocrinol. (Oxf.)61:510-514(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-40
    19. 19.
      "Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations."
      Neumann H.P.H. , Pawlu C. , Peczkowska M. , Bausch B. , McWhinney S.R. , Muresan M. , Buchta M. , Franke G. , Klisch J. , Bley T.A. , Hoegerle S. , Boedeker C.C. , Opocher G. , Schipper J. , Januszewicz A. , Eng C.
      JAMA292:943-951(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PCC GLY-46; GLN-46; ARG-53; PRO-65; SER-87; TYR-101; ARG-192; TYR-196 AND HIS-242;VARIANTS PGL4 GLN-46 AND HIS-242
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    21. 21.
      "A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas."
      Maier-Woelfle M. , Braendle M. , Komminoth P. , Saremaslani P. , Schmid S. , Locher T. , Heitz P.U. , Krull I. , Galeazzi R.L. , Schmid C. , Perren A.
      J. Clin. Endocrinol. Metab.89:362-367(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PGL4 PRO-132
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PCC PHE-100
    23. 23.
      "Familial gastrointestinal stromal tumors and germ-line mutations."
      McWhinney S.R. , Pasini B. , Stratakis C.A.
      N. Engl. J. Med.357:1054-1056(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PGGSS
    24. 24.
      "Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes."
      Ni Y. , Zbuk K.M. , Sadler T. , Patocs A. , Lobo G. , Edelman E. , Platzer P. , Orloff M.S. , Waite K.A. , Eng C.
      Am. J. Hum. Genet.83:261-268(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS2 GLY-3 AND PRO-163;CHARACTERIZATION OF VARIANTS CWS2 GLY-3 AND PRO-163
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