Gene name:
SDHB (SDH;SDH1) ;
Protein name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial ;
Alternative:
Iron-sulfur subunit of complex II (Ip) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
Function:
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Subcellular Location:
Mitochondrion inner membrane
Peripheral membrane protein
Matrix side
Protein Attributes:
50:
MAAVVALSLR | RRLPATTLGG | ACLQASRGAQ | TAAATAPRIK | KFAIYRWDPD |
100:
KAGDKPHMQT | YEVDLNKCGP | MVLDALIKIK | NEVDSTLTFR | RSCREGICGS |
150:
CAMNINGGNT | LACTRRIDTN | LNKVSKIYPL | PHMYVIKDLV | PDLSNFYAQY |
200:
KSIEPYLKKK | DESQEGKQQY | LQSIEEREKL | DGLYECILCA | CCSTSCPSYW |
250:
WNGDKYLGPA | VLMQAYRWMI | DSRDDFTEER | LAKLQDPFSL | YRCHTIMNCT |
280:
RTCPKGLNPG | KAIAEIKKMM | ATYKEKKASV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Chicken
Human
Pig
Chicken
Bovine
Mouse
Mouse
Rat
Bovine
Pig
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ELISA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
CLIA Kit for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Polyclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Monoclonal Antibody for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein for Human Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue :
Liver .
2.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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Nat. Genet.36:40-45(2004)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Uterus .
3.
"The DNA sequence and biological annotation of human chromosome 1."
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
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,
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,
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,
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,
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,
Lu F.
,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 10-264
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 19-280
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 107-249
tissue :
Fibroblast .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
10.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PGL4 ARG-197;VARIANT PCC SER-87
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FAMILIAL MALIGNANT PARAGANGLIOMA HIS-242
13.
"Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas."
Baysal B.E.
,
Willett-Brozick J.E.
,
Lawrence E.C.
,
Drovdlic C.M.
,
Savul S.A.
,
McLeod D.R.
,
Yee H.A.
,
Brackmann D.E.
,
Slattery W.H. III
,
Myers E.N.
,
Ferrell R.E.
,
Rubinstein W.S.
J. Med. Genet.39:178-183(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PGL4 ARG-131
14.
"Germ-line mutations in nonsyndromic pheochromocytoma."
The Freiburg-Warsaw-Columbus pheochromocytoma study group
,
Neumann H.P.H.
,
Bausch B.
,
McWhinney S.R.
,
Bender B.U.
,
Gimm O.
,
Franke G.
,
Schipper J.
,
Klisch J.
,
Altehoefer C.
,
Zerres K.
,
Januszewicz A.
,
Smith W.M.
,
Munk R.
,
Manz T.
,
Glaesker S.
,
Apel T.W.
,
Treier M.
,
Reineke M.
,
Walz M.K.
,
Hoang-Vu C.
,
Brauckhoff M.
,
Klein-Franke A.
,
Klose P.
,
Schmidt H.
,
Maier-Woelfle M.
,
Peczkowska M.
,
Szmigielski C.
,
Eng C.
more...
N. Engl. J. Med.346:1459-1466(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PCC GLN-29 INS; GLY-46; TYR-101; ARG-192; TYR-196 AND HIS-242
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PCC PRO-43; GLN-46; GLY-46 AND CYS-230
16.
"Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility."
Astuti D.
,
Hart-Holden N.
,
Latif F.
,
Lalloo F.
,
Black G.C.
,
Lim C.
,
Moran A.
,
Grossman A.B.
,
Hodgson S.V.
,
Freemont A.
,
Ramsden R.
,
Eng C.
,
Evans D.G.R.
,
Maher E.R.
Clin. Endocrinol. (Oxf.)59:728-733(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PCC ASN-127;VARIANT PGL4 ARG-197
17.
"Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas."
Benn D.E.
,
Croxson M.S.
,
Tucker K.
,
Bambach C.P.
,
Richardson A.L.
,
Delbridge L.
,
Pullan P.T.
,
Hammond J.
,
Marsh D.J.
,
Robinson B.G.
Oncogene22:1358-1364(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PCC GLN-46 AND HIS-65
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLU-40
19.
"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations."
Neumann H.P.H.
,
Pawlu C.
,
Peczkowska M.
,
Bausch B.
,
McWhinney S.R.
,
Muresan M.
,
Buchta M.
,
Franke G.
,
Klisch J.
,
Bley T.A.
,
Hoegerle S.
,
Boedeker C.C.
,
Opocher G.
,
Schipper J.
,
Januszewicz A.
,
Eng C.
JAMA292:943-951(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PCC GLY-46; GLN-46; ARG-53; PRO-65; SER-87; TYR-101; ARG-192; TYR-196 AND HIS-242;VARIANTS PGL4 GLN-46 AND HIS-242
20.
Neumann H.P.H.
,
Pawlu C.
,
Peczkowska M.
,
Bausch B.
,
McWhinney S.R.
,
Muresan M.
,
Buchta M.
,
Franke G.
,
Klisch J.
,
Bley T.A.
,
Hoegerle S.
,
Boedeker C.C.
,
Opocher G.
,
Schipper J.
,
Januszewicz A.
,
Eng C.
JAMA292:1686-1686(2004)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
21.
"A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas."
Maier-Woelfle M.
,
Braendle M.
,
Komminoth P.
,
Saremaslani P.
,
Schmid S.
,
Locher T.
,
Heitz P.U.
,
Krull I.
,
Galeazzi R.L.
,
Schmid C.
,
Perren A.
J. Clin. Endocrinol. Metab.89:362-367(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PGL4 PRO-132
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PCC PHE-100
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN PGGSS
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CWS2 GLY-3 AND PRO-163;CHARACTERIZATION OF VARIANTS CWS2 GLY-3 AND PRO-163