Protein name:
E3 ubiquitin-protein ligase SH3RF1 ;
Alternative:
SH3 domain-containing RING finger protein 1 ;Plenty of SH3s (Protein POSH) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with Rac; in a GTP-dependent manner. Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.
Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.
Subcellular Location:
Cytoplasm
perinuclear region
Cell projection
lamellipodium
Golgi apparatus
trans-Golgi network
Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network.
Protein Attributes:
50:
MDESALLDLL | ECPVCLERLD | ASAKVLPCQH | TFCKRCLLGI | VGSRNELRCP |
100:
ECRTLVGSGV | EQLPSNILLV | RLLDGIKQRP | WKPGPVGGSG | TNGTSALRAQ |
150:
SSAVVTCSPK | DGPSSQGGPQ | PRAQAWSPPV | RGIPQLPCAK | ALYNYEGKEP |
200:
GDLKFSKGDI | IVLRRQVDEN | WYHGEVGGVH | GFFPTNFVQI | IKPLPQPPPQ |
250:
CKALYDFEVK | DKEADKDCLP | FAKDDVLTVI | RRVDENWAEG | MLADKIGIFP |
300:
ISYVEFNSAA | KQLIEWDQPP | GPGVAAGEGA | LATTPSSTTT | KQPDGKKNTK |
350:
KRHSFTSLSM | ASKASQAAQQ | RHSMEISPPV | LISSSNPAAA | ARIGELAGLS |
400:
CSAPSQVHIS | TTGLIVTPPP | SSPVTTGPSF | TFPAEAPYPA | ALATLNPPLP |
450:
PPPLQAATPT | GTAVAAAAGM | GPRPTAGPTD | QTTHPRPQPR | PSVYVAIYPY |
500:
TPRKEDELEL | RKGEMFLVFE | RCQDGWFKGT | SMHTSKIGVF | PGNYVAPVTR |
550:
AVTSASQGKV | PMLTTGPASR | GGVLANPPST | GGPAQKPPGN | GVAGGPGVPT |
600:
AVVSAAHVQT | SPQAKVLLHA | SGQMTVNQAR | SAARTVSAHS | QERPTAAVTP |
650:
IQVQSTPGQS | HHPLVSPQPP | APLGPPAHAA | ASGLGRVGGP | LACATAPASI |
700:
PAASLEPEPS | SRPATLLPGT | PTSPDSGSAA | RPDKDGKKEK | KGLLKLLSGA |
750:
STKRKPRGSP | PASPTLDAEL | GAELSCGPPG | PPCACPGPCD | GDTMAPGPQR |
800:
RASSLDSAPV | APPPRQPCSS | LGPAASEVRP | AVCERHRVVV | SYPPQSEAEL |
840:
ELKEGDIVFV | HKKREDGWFK | GTLQRNGKTG | LFPGSFVENI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
ELISA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
ELISA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
ELISA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
CLIA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
CLIA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
CLIA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
CLIA Kit for Bovine E3 ubiquitin-protein ligase SH3RF1
Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase SH3RF1
Protein for Bovine E3 ubiquitin-protein ligase SH3RF1
Protein for Bovine E3 ubiquitin-protein ligase SH3RF1
Protein for Bovine E3 ubiquitin-protein ligase SH3RF1
Protein for Bovine E3 ubiquitin-protein ligase SH3RF1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hypothalamus .