Sipa1l1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSipa1l1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Sipa1l1(Gene name) > Rat

Sipa1l1 (Gene name),

Signal-induced proliferation-associated 1-like protein 1 (Protein name ), SI1L1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Sipa1l1(Spa1);

Protein name:

Signal-induced proliferation-associated 1-like protein 1(SIPA1-like protein 1);

Alternative:

Spine-associated Rap GTPase-activating protein(SPAR);SPA-1-like protein p1294;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases (By similarity). Interacts with DLG4, PDLIM5, PDLIM7 and PROSAPIP1. Interacts with the actin cytoskeleton.

Function:

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.

Subcellular Location:

Cytoplasm cytoskeleton Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse synaptosome Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.

Protein Attributes:

Sequence length:

1822

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1822:

SQNASDKLKK | FTEWVFNTID | MS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O35412

KEGG:

rno:246212

Pfam:

PF11881

STRING:

10116.ENSRNOP00000010626

UniGene:

Rn.10835

Uniprot:

O35412

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ELISA Kit for Rat SIPA1-like protein 1

Cat.:

E6550m

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Packing:

96T

ELISA Kit for Rat SIPA1-like protein 1

Cat.:

E6550r

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96T

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ELISA Kit for Rat SIPA1-like protein 1

Cat.:

E6550h

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96T

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CLIA Kit for Rat SIPA1-like protein 1

Cat.:

U6550m

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Packing:

96T

CLIA Kit for Rat SIPA1-like protein 1

Cat.:

U6550h

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Packing:

96T

CLIA Kit for Rat SIPA1-like protein 1

Cat.:

U6550r

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Packing:

96T

Polyclonal Antibody for Rat SIPA1-like protein 1

Cat.:

P6550Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat SIPA1-like protein 1

Cat.:

P6550Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat SIPA1-like protein 1

Monoclonal Antibody for Rat SIPA1-like protein 1

Protein for Rat SIPA1-like protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Sipa1l1 is an early biomarker of liver fibrosis in CCl4-treated rats"

Zakaria S, El-Sisi A.

From:Biology open

References

1.

Takeuchi M. , Ide N. , Hata Y. , Takai Y.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP."
Pak D.T. , Yang S. , Rudolph-Correia S. , Kim E. , Sheng M.
Neuron31:289-303(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DLG4;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-743 AND 846-ARG-THR-847;TISSUE SPECIFICITY
3.

"ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3."
Wendholt D. , Spilker C. , Schmitt A. , Dolnik A. , Smalla K.H. , Proepper C. , Bockmann J. , Sobue K. , Gundelfinger E.D. , Kreutz M.R. , Boeckers T.M.
J. Biol. Chem.281:13805-13816(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LZTS3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.

"The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
Richter M. , Murai K.K. , Bourgin C. , Pak D.T. , Pasquale E.B.
J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
5.

"Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons."
Ang X.L. , Seeburg D.P. , Sheng M. , Harper J.W.
J. Biol. Chem.283:29424-29432(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1344 AND THR-1348;UBIQUITINATION;MUTAGENESIS OF SER-1344 AND THR-1348
6.

"Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity."
Seeburg D.P. , Feliu-Mojer M. , Gaiottino J. , Pak D.T. , Sheng M.
Neuron58:571-583(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1367;UBIQUITINATION;MUTAGENESIS OF SER-1367
7.

"Postsynaptic PDLIM5/Enigma homolog binds SPAR and causes dendritic spine shrinkage."
Herrick S. , Evers D.M. , Lee J.Y. , Udagawa N. , Pak D.T.
Mol. Cell. Neurosci.43:188-200(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDLIM5 AND PDLIM7
8.

"Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory."
Lee K.J. , Lee Y. , Rozeboom A. , Lee J.Y. , Udagawa N. , Hoe H.S. , Pak D.T.
Neuron69:957-973(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;UBIQUITINATION

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