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Index > Protein center > Cd84(Gene name) > Mouse
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  • Cd84 (Gene name),
  • SLAM family member 5 (Protein name ),  SLAF5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cd84(Slamf5);
    Protein name:
    SLAM family member 5;
    Alternative:
    Signaling lymphocytic activation molecule 5;Leukocyte differentiation antigen CD84;
    CD:
    CD84;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A.
    Function:
    Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    329
    Sequence:
    50:
    MAQRHLWIWF | LCLQTWSEAA | GKDADPMVMN | GILGESVTFL | LNIQEPKKID | 
    100:
    NIAWTSQSSV | AFIKPGVNKA | EVTITQGTYK | GRIEIIDQKY | DLVIRDLRME | 
    150:
    DAGTYKADIN | EENEETITKI | YYLHIYRRLK | TPKITQSLIS | SLNNTCNITL | 
    200:
    TCSVEKEEKD | VTYSWSPFGE | KSNVLQIVHS | PMDQKLTYTC | TAQNPVSNSS | 
    250:
    DSVTVQQPCT | DTPSFHPRHA | VLPGGLAVLF | LLILIPMLAF | LFRLYKRRRD | 
    300:
    RIVLEADDVS | KKTVYAVVSR | NAQPTESRIY | DEIPQSKMLS | CKEDPVTTIY | 
    329:
    SSVQLSEKMK | ETNMKDRSLP | KALGNEIVV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SLAM family member 5
    Cat.:
    E9091h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse SLAM family member 5
    Cat.:
    E9091m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse SLAM family member 5
    Cat.:
    U9091h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SLAM family member 5
    Cat.:
    U9091m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse SLAM family member 5
    Cat.:
    P9091Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SLAM family member 5
    Cat.:
    P9091Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse SLAM family member 5
    Monoclonal Antibody for Mouse SLAM family member 5
    Protein for Mouse SLAM family member 5
    Protein for Mouse SLAM family member 5

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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning, characterization, and chromosomal localization of the mouse homologue of CD84, a member of the CD2 family of cell surface molecules."
      de la Fuente M.A. , Tovar V. , Pizcueta P. , Nadal M. , Bosch J. , Engel P.
      Immunogenetics49:249-255(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-293
      tissue: Peritoneal macrophage.
    2. 2.
      "Polymorphisms of SLAM family receptor genes."
      Furukawa H. , Ono M.
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-293
      strain: BXSB/MpJ.
      strain: MRL/MpJ.
      strain: NZB/BlNJ.
      strain: NZW/LacJ.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT LYS-293
      strain: NOD.
    4. 4.
      "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells."
      Morra M. , Lu J. , Poy F. , Martin M. , Sayos J. , Calpe S. , Gullo C. , Howie D. , Rietdijk S. , Thompson A. , Coyle A.J. , Denny C. , Yaffe M.B. , Engel P. , Eck M.J. , Terhorst C.
      EMBO J.20:5840-5852(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2D1B
    5. 5.
      "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling."
      Nanda N. , Andre P. , Bao M. , Clauser K. , Deguzman F. , Howie D. , Conley P.B. , Terhorst C. , Phillips D.R.
      Blood106:3028-3034(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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