Smarca5 ELISA Kit for Mouse(Mus musculus) | EIAab.comSmarca5 ELISA Kit for Mouse(Mus musculus)

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Smarca5 (Gene name),

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (Protein name ), SMCA5_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Smarca5(Snf2h);

Protein name:

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;

Alternative:

Sucrose nonfermenting protein 2 homolog(mSnf2h);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains HBXAP; WICH contains BAZ1B/WSTF.SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A/TIP5. The BAZ2A/TIP5 subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation. Catalytic subunit of SMARCA5/cohesin/NuRD complexes. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with MYO1C.

Function:

Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1051

Sequence:

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1000:

1050:

1051:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q91ZW3

KEGG:

mmu:93762

UniGene:

Mm.246803

String:

Q91ZW3

Pfam:

PF09110

Pfam:

PF13892

Uniprot:

Q91ZW3

FOR

ELISA Kit for Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

CLIA Kit for Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Polyclonal Antibody for Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Monoclonal Antibody for Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Protein for Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia."
Stopka T. , Zakova D. , Fuchs O. , Kubrova O. , Blafkova J. , Jelinek J. , Necas E. , Zivny J.
Leukemia14:1247-1252(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
tissue: Erythroleukemia.
2.

"Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l."
Lazzaro M.A. , Picketts D.J.
J. Neurochem.77:1145-1156(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
strain: FVB/N.
tissue: Brain.
tissue: Mammary gland.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-1007
strain: C57BL/6J.
tissue: Heart.
tissue: Thymus.
5.

"NoRC -- a novel member of mammalian ISWI-containing chromatin remodeling machines."
Strohner R. , Nemeth A. , Jansa P. , Hofmann-Rohrer U. , Santoro R. , Laengst G. , Grummt I.
EMBO J.20:4892-4900(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE NORC COMPLEX;INTERACTION WITH BAZ2A
6.

"WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci."
Bozhenok L. , Wade P.A. , Varga-Weisz P.
EMBO J.21:2231-2241(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE WICH COMPLEX;INTERACTION WITH BAZ1B
7.

"The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription."
Zhou Y. , Santoro R. , Grummt I.
EMBO J.21:4632-4640(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE NORC COMPLEX;INTERACTION WITH BAZ2A AND HDAC1
8.

"The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription."
Santoro R. , Li J. , Grummt I.
Nat. Genet.32:393-396(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BAZ2A; DNMT1; DNMT3B AND HDAC1
9.

"The ISWI ATPase Snf2h is required for early mouse development."
Stopka T. , Skoultchi A.I.
Proc. Natl. Acad. Sci. U.S.A.100:14097-14102(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Functional diversity of ISWI complexes."
Dirscherl S.S. , Krebs J.E.
Biochem. Cell Biol.82:482-489(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;CHARACTERIZATION OF ISWI COMPLEXES
11.

"The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription."
Percipalle P. , Fomproix N. , Cavellan E. , Voit R. , Reimer G. , Krueger T. , Thyberg J. , Scheer U. , Grummt I. , Oestlund Farrants A.-K.O.
EMBO Rep.7:525-530(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO1C
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity."
Xiao A. , Li H. , Shechter D. , Ahn S.H. , Fabrizio L.A. , Erdjument-Bromage H. , Ishibe-Murakami S. , Wang B. , Tempst P. , Hofmann K. , Patel D.J. , Elledge S.J. , Allis C.D.
Nature457:57-62(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BAZ1B
15.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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