Gene name:
Sgms1 (Mob;Tmem23) ;
Protein name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1 ;
Alternative:
Sphingomyelin synthase 1 ;Protein Mob ;Transmembrane protein 23 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
Subcellular Location:
Golgi apparatus membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLSASTMKEV | VYWSPKKVAD | WLLENAMPEY | CEPLGHFTGQ | DLINLTQEDF |
100:
TKPPLCRVSS | DNGQRLLDMI | ETLKMEHHIE | AHKNGHANGH | LSIGVDIPNP |
150:
DGSFSIKIKP | NGMPNGFRKE | MIKIPMPEPE | RSQYPMEWGK | TLLAFLYALS |
200:
CFVLTTVMIS | VVHERVPPKE | VQPPLPDTFF | DHFNRVQWAF | SICEINGMIL |
250:
VGLWLFQWLL | LKYKSIISRR | FFCIVGTLYL | YRCITMYVTT | LPVPGMHFNC |
300:
SPKLFGDWEA | QVRRIMKLIA | GGGLSITGSH | NMCGDYLYSG | HTVMLTLTYL |
350:
FIKEYSPRRL | WWYHWICWLL | SVVGIFCILL | AHDHYTVDVV | VAYYITTRLF |
400:
WWYHTMANQQ | VLKEASQMNL | LARVWWYRPF | QYFEKNVQGI | VPRSYHWPLP |
419:
WPVVHLSRQV | KYSRLVNDT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Pig
Mouse
Chicken
ELISA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Rat Phosphatidylcholine:ceramide cholinephosphotransferase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Complete cDNA sequence of a novel gene, rat mob."
Yuan H.F.
,
Wang X.
,
Wang D.M.
,
Li H.M.
,
Feng K.
,
Bai C.X.
,
Zhang R.
,
Chen L.
,
Li Y.H.
,
Gao Y.H.
,
Zhen M.
,
Yue W.
,
Xie C.
,
Xie X.Y.
,
Niu L.L.
,
Yue W.
,
Zhang J.
,
Cao H.
,
Pei X.T.
more...
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Wistar .
tissue :
Heart .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .