Protein name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2 ;
Alternative:
Sphingomyelin synthase 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Golgi apparatus membrane
Multi-pass membrane protein
Predominantly plasma membrane, some in Golgi apparatus.
Protein Attributes:
50:
MDIIETAKLE | GHLESQTNDS | TNTYTSPTEA | VEEEGKNGKG | KPKTLSNGLR |
100:
KGAKKYPDYI | QISMPNDSKN | KFPLEWWKTG | IAFVYALFNL | ILTTVMITVV |
150:
HERVPPKELS | PPLPDKFFDY | FDRVKWAFSV | SEINGMVLVG | LWITQWLFLR |
200:
YKSIVGRRFF | FIMGTLYLYR | CITMYVTTLP | VPGMHFQCAP | KLNGDSQAKI |
250:
QRILRLISGG | GLSITGSHIL | CGDFLFSGHT | VVLTLTYLFI | KEYSPRHFWW |
300:
YHLVCWLLSA | AGIICILVAH | EHYTVDVIIA | YYITTRLFWW | YHSMANEKNL |
350:
KVSSQTNFLS | RAWWFPIFYF | FEKNVQGSIP | CCFSWPLSWP | PGCFKSSCRK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;FUNCTION
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[
Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION