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Index > Protein center > Sgms2(Gene name) > Mouse
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  • Sgms2 (Gene name),
  • Phosphatidylcholine:ceramide cholinephosphotransferase 2 (Protein name ),  SMS2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Sgms2;
    Protein name:
    Phosphatidylcholine:ceramide cholinephosphotransferase 2;
    Alternative:
    Sphingomyelin synthase 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Predominantly plasma membrane, some in Golgi apparatus.
    Protein Attributes:
    Sequence length:
    365
    Sequence:
    50:
    MDIIETAKLE | GHLESQTNDS | TNTYTSPTEA | VEEEGKNGKG | KPKTLSNGLR | 
    100:
    KGAKKYPDYI | QISMPNDSKN | KFPLEWWKTG | IAFVYALFNL | ILTTVMITVV | 
    150:
    HERVPPKELS | PPLPDKFFDY | FDRVKWAFSV | SEINGMVLVG | LWITQWLFLR | 
    200:
    YKSIVGRRFF | FIMGTLYLYR | CITMYVTTLP | VPGMHFQCAP | KLNGDSQAKI | 
    250:
    QRILRLISGG | GLSITGSHIL | CGDFLFSGHT | VVLTLTYLFI | KEYSPRHFWW | 
    300:
    YHLVCWLLSA | AGIICILVAH | EHYTVDVIIA | YYITTRLFWW | YHSMANEKNL | 
    350:
    KVSSQTNFLS | RAWWFPIFYF | FEKNVQGSIP | CCFSWPLSWP | PGCFKSSCRK | 
    365:
    YSRVQKIGED | NEKST
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    E12539h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    E12539r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    E12539m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    U12539h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    U12539m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    U12539r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    P12539Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    P12539Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Cat.:
    P12539Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Monoclonal Antibody for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Protein for Mouse Phosphatidylcholine:ceramide cholinephosphotransferase 2

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    Precision
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Identification of a family of animal sphingomyelin synthases."
      Huitema K. , Van Den Dikkenberg J. , Brouwers J.F.H.M. , Holthuis J.C.
      EMBO J.23:33-44(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    4. 4.
      "Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice."
      Liu J. , Huan C. , Chakraborty M. , Zhang H. , Lu D. , Kuo M.S. , Cao G. , Jiang X.C.
      Circ. Res.105:295-303(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;FUNCTION
    5. 5.
      "Reducing plasma membrane sphingomyelin increases insulin sensitivity."
      Li Z. , Zhang H. , Liu J. , Liang C.P. , Li Y. , Li Y. , Teitelman G. , Beyer T. , Bui H.H. , Peake D.A. , Zhang Y. , Sanders P.E. , Kuo M.S. , Park T.S. , Cao G. , Jiang X.C.
      Mol. Cell. Biol.31:4205-4218(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    6. 6.
      "Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice."
      Li Z. , Fan Y. , Liu J. , Li Y. , Huan C. , Bui H.H. , Kuo M.S. , Park T.S. , Cao G. , Jiang X.C.
      Arterioscler. Thromb. Vasc. Biol.32:1577-1584(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    7. 7.
      "Mechanisms involved in cellular ceramide homeostasis."
      Hussain M.M. , Jin W. , Jiang X.C.
      Nutr. Metab.9:71-71(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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