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Index > Protein center > SMUG1(Gene name) > Human
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  • SMUG1 (Gene name),
  • Single-strand selective monofunctional uracil DNA glycosylase (Protein name ),  SMUG1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SMUG1;
    Protein name:
    Single-strand selective monofunctional uracil DNA glycosylase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    270
    Sequence:
    50:
    MPQAFLLGSI | HEPAGALMEP | QPCPGSLAES | FLEEELRLNA | ELSQLQFSEP | 
    100:
    VGIIYNPVEY | AWEPHRNYVT | RYCQGPKEVL | FLGMNPGPFG | MAQTGVPFGE | 
    150:
    VSMVRDWLGI | VGPVLTPPQE | HPKRPVLGLE | CPQSEVSGAR | FWGFFRNLCG | 
    200:
    QPEVFFHHCF | VHNLCPLLFL | APSGRNLTPA | ELPAKQREQL | LGICDAALCR | 
    250:
    QVQLLGVRLV | VGVGRLAEQR | ARRALAGLMP | EVQVEGLLHP | SPRNPQANKG | 
    270:
    WEAVAKERLN | ELGLLPLLLK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
    Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
    Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
    Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
    Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
    Protein for Human Single-strand selective monofunctional uracil DNA glycosylase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors."
      Haushalter K.A. , Stukenberg P.T. , Kirschner M.W. , Verdine G.L.
      Curr. Biol.9:174-185(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
      tissue: Ovary.
    2. 2.
      "Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions."
      Masaoka A. , Matsubara M. , Hasegawa R. , Tanaka T. , Kurisu S. , Terato H. , Ohyama Y. , Karino N. , Matsuda A. , Ide H.
      Biochemistry42:5003-5012(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Colon.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Adipose tissue.
    5. 5.
      NIEHS SNPs program
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-15 AND TRP-105
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Muscle.
      tissue: Uterus.
    8. 8.
      "Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1."
      Boorstein R.J. , Cummings A. Jr. , Marenstein D.R. , Chan M.K. , Ma Y. , Neubert T.A. , Brown S.M. , Teebor G.W.
      J. Biol. Chem.276:41991-41997(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 13-21; 26-37; 46-66; 79-105; 124-140; 141-146; 147-157; 188-200; 201-208; 224-243 AND 259-270;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
    9. 9.
      "hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup."
      Kavli B. , Sundheim O. , Akbari M. , Otterlei M. , Nilsen H. , Skorpen F. , Aas P.A. , Hagen L. , Krokan H.E. , Slupphaug G.
      J. Biol. Chem.277:39926-39936(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    10. 10.
      "Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase."
      Matsubara M. , Tanaka T. , Terato H. , Ohmae E. , Izumi S. , Katayanagi K. , Ide H.
      Nucleic Acids Res.32:5291-5302(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-85; GLY-87; PHE-89; GLY-90; MET-91; PHE-98; ASN-163 AND HIS-239
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