Protein name:
Single-strand selective monofunctional uracil DNA glycosylase ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MPQAFLLGSI | HEPAGALMEP | QPCPGSLAES | FLEEELRLNA | ELSQLQFSEP |
100:
VGIIYNPVEY | AWEPHRNYVT | RYCQGPKEVL | FLGMNPGPFG | MAQTGVPFGE |
150:
VSMVRDWLGI | VGPVLTPPQE | HPKRPVLGLE | CPQSEVSGAR | FWGFFRNLCG |
200:
QPEVFFHHCF | VHNLCPLLFL | APSGRNLTPA | ELPAKQREQL | LGICDAALCR |
250:
QVQLLGVRLV | VGVGRLAEQR | ARRALAGLMP | EVQVEGLLHP | SPRNPQANKG |
270:
WEAVAKERLN | ELGLLPLLLK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Bovine
ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
ELISA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
CLIA Kit for Human Single-strand selective monofunctional uracil DNA glycosylase
Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Polyclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Monoclonal Antibody for Human Single-strand selective monofunctional uracil DNA glycosylase
Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
Protein for Human Single-strand selective monofunctional uracil DNA glycosylase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
tissue :
Ovary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Colon .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Adipose tissue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-15 AND TRP-105
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Muscle .
tissue :
Uterus .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 13-21; 26-37; 46-66; 79-105; 124-140; 141-146; 147-157; 188-200; 201-208; 224-243 AND 259-270;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
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[
PubMed ]
[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF ASN-85; GLY-87; PHE-89; GLY-90; MET-91; PHE-98; ASN-163 AND HIS-239