Vacuolar-sorting protein SNF8 (Protein name
), SNF8_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
SNF8(EAP30);
Protein name:
Vacuolar-sorting protein SNF8;
Alternative:
ESCRT-II complex subunit VPS22(hVps22);ELL-associated protein of 30 kDa;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36. SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL. Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins.
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Subcellular Location:
Cytoplasm
Endosome membrane
Nucleus
Late endosome membrane
Recruited to the endosome membrane to participate in vesicle formation.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for: SELF-ASSOCIATION;INTERACTION WITH VPS25; VPS36 AND TSG101
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Cited for: IDENTIFICATION IN THE ESCRT-II COMPLEX;INTERACTION WITH VPS36 AND VPS25
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Cited for: INTERACTION WITH VPS25; VPS36 AND RILPL1;SUBCELLULAR LOCATION
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Cited for: INTERACTION WITH VPS25; VPS36 AND TSG101;SUBCELLULAR LOCATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 25-258 IN COMPLEX WITH VPS25 AND VPS36
Vaild Sequence:
