Gene name:
Snf8 (D11Moh34) ;
Protein name:
Vacuolar-sorting protein SNF8 ;
Alternative:
ESCRT-II complex subunit VPS22 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36. SNF8 is essential for the stability of the ESCRT-II complex. ESCRT-II interacts with ELL. Interacts with TSG101 (via the C-terminal domain). Interacts with RILPL1 (via the N-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with 14-3-3 proteins.
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization.
Subcellular Location:
Cytoplasm
Endosome membrane
Nucleus
Late endosome membrane
Recruited to the endosome membrane to participate in vesicle formation.
Protein Attributes:
50:
MHRRGVGAGA | IAKKKLAEAK | YKERGTVLAE | DQLAQMSKQL | DMFKTNLEEF |
100:
ASKHKQEIRK | NPEFRVQFQD | MCATIGVDPL | ASGKGFWSEM | LGVGDFYYEL |
150:
GVQIIEVCLA | LKHRNGGLIT | LEELHQQVLK | GRGKFAQDVS | QDDLIRAIKK |
200:
LKALGTGFGI | IPVGGTYLIQ | SVPAELNMDH | TVVLQLAEKN | GYVTVSEIKT |
250:
SLKWETERAR | QVLEHLLKEG | LAWLDLQAPG | EAHYWLPALF | TDLYSQEISA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Vacuolar-sorting protein SNF8
ELISA Kit for Mouse Vacuolar-sorting protein SNF8
ELISA Kit for Mouse Vacuolar-sorting protein SNF8
CLIA Kit for Mouse Vacuolar-sorting protein SNF8
CLIA Kit for Mouse Vacuolar-sorting protein SNF8
CLIA Kit for Mouse Vacuolar-sorting protein SNF8
Polyclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Polyclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Polyclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Monoclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Monoclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Monoclonal Antibody for Mouse Vacuolar-sorting protein SNF8
Protein for Mouse Vacuolar-sorting protein SNF8
Protein for Mouse Vacuolar-sorting protein SNF8
Protein for Mouse Vacuolar-sorting protein SNF8
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
2.
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PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .