Gene name:
Slco1a4 (Oatp1a4;Oatp2;Slc21a5) ;
Protein name:
Solute carrier organic anion transporter family member 1A4 ;
Alternative:
Brain-specific organic anion transporter ;Brain digoxin carrier protein ;Sodium-independent organic anion-transporting polypeptide 2 ;OATP-B1 ;Solute carrier family 21 member 5 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGKSEKRVAT | HGVRCFAKIK | MFLLALTCAY | VSKSLSGTYM | NSMLTQIERQ |
100:
FGIPTSIVGL | INGSFEIGNL | LLIIFVSYFG | TKLHRPIMIG | VGCAVMGLGC |
150:
FLISLPHFLM | GQYEYETILP | TSNVSSNSFF | CVENRSQTLN | PTQDPSECVK |
200:
EMKSLMWIYV | LVGNIIRGIG | ETPIMPLGIS | YIEDFAKSEN | SPLYIGILET |
250:
GMTIGPLIGL | LLASSCANIY | VDIESVNTDD | LTITPTDTRW | VGAWWIGFLV |
300:
CAGVNILTSF | PFFFFPKTLP | KEGLQENVDG | TENAKEKKHR | KKAKEEKRGI |
350:
TKDFFVFMKS | LSCNPIYMLF | ILISVLQFNA | FINSFTFMPK | YLEQQYGKST |
400:
AEVVFLMGLY | MLPPICLGYL | IGGLIMKKFK | VTVKKAAHLA | FWLCLSEYLL |
450:
SFLSYVMTCD | NFPVAGLTTS | YEGVQHQLYV | ENKVLADCNT | RCNCSTNTWD |
500:
PVCGDNGLAY | MSACLAGCEK | SVGTGTNMVF | QNCSCIQSSG | NSSAVLGLCN |
550:
KGPDCANKLQ | YFLIIAIFGC | FIYSLAGIPG | YMVLLRCIKS | EEKSLGVGLH |
600:
AFCIRILAGI | PAPIYFGALI | DRTCLHWGTL | KCGEPGACRM | YDINSFRRLY |
650:
LGLPAALRGA | SFVPAFFILR | LTRTFQFPGD | IESSKTDHAE | MKLTLKESEC |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
ELISA Kit for Rat Solute carrier organic anion transporter family member 1A4
ELISA Kit for Rat Solute carrier organic anion transporter family member 1A4
CLIA Kit for Rat Solute carrier organic anion transporter family member 1A4
CLIA Kit for Rat Solute carrier organic anion transporter family member 1A4
Polyclonal Antibody for Rat Solute carrier organic anion transporter family member 1A4
Polyclonal Antibody for Rat Solute carrier organic anion transporter family member 1A4
Monoclonal Antibody for Rat Solute carrier organic anion transporter family member 1A4
Monoclonal Antibody for Rat Solute carrier organic anion transporter family member 1A4
Protein for Rat Solute carrier organic anion transporter family member 1A4
Protein for Rat Solute carrier organic anion transporter family member 1A4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Brain .
2.
"Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2."
Abe T.
,
Kakyo M.
,
Sakagami H.
,
Tokui T.
,
Nishio T.
,
Tanemoto M.
,
Nomura H.
,
Hebert S.C.
,
Matsuno S.
,
Kondo H.
,
Yawo H.
J. Biol. Chem.273:22395-22401(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Retina .