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Index > Protein center > SLCO1B1(Gene name) > Human
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  • SLCO1B1 (Gene name),
  • Solute carrier organic anion transporter family member 1B1 (Protein name ),  SO1B1_HUMAN from NCBI database.
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  • General Annotation
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    • Gene name:
    SLCO1B1(LST1;OATP1B1;OATP2;OATPC;SLC21A6);
    Protein name:
    Solute carrier organic anion transporter family member 1B1;
    Alternative:
    OATP-C;Liver-specific organic anion transporter 1(LST-1);Solute carrier family 21 member 6;Sodium-independent organic anion-transporting polypeptide 2(OATP-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
    Subcellular Location:
    Basolateral cell membrane Multi-pass membrane protein Detected in basolateral membranes of hepatocytes.
    Protein Attributes:
    Sequence length:
    691
    Sequence:
    50:
    MDQNQHLNKT | AEAQPSENKK | TRYCNGLKMF | LAALSLSFIA | KTLGAIIMKS | 
    100:
    SIIHIERRFE | ISSSLVGFID | GSFEIGNLLV | IVFVSYFGSK | LHRPKLIGIG | 
    150:
    CFIMGIGGVL | TALPHFFMGY | YRYSKETNIN | SSENSTSTLS | TCLINQILSL | 
    200:
    NRASPEIVGK | GCLKESGSYM | WIYVFMGNML | RGIGETPIVP | LGLSYIDDFA | 
    250:
    KEGHSSLYLG | ILNAIAMIGP | IIGFTLGSLF | SKMYVDIGYV | DLSTIRITPT | 
    300:
    DSRWVGAWWL | NFLVSGLFSI | ISSIPFFFLP | QTPNKPQKER | KASLSLHVLE | 
    350:
    TNDEKDQTAN | LTNQGKNITK | NVTGFFQSFK | SILTNPLYVM | FVLLTLLQVS | 
    400:
    SYIGAFTYVF | KYVEQQYGQP | SSKANILLGV | ITIPIFASGM | FLGGYIIKKF | 
    450:
    KLNTVGIAKF | SCFTAVMSLS | FYLLYFFILC | ENKSVAGLTM | TYDGNNPVTS | 
    500:
    HRDVPLSYCN | SDCNCDESQW | EPVCGNNGIT | YISPCLAGCK | SSSGNKKPIV | 
    550:
    FYNCSCLEVT | GLQNRNYSAH | LGECPRDDAC | TRKFYFFVAI | QVLNLFFSAL | 
    600:
    GGTSHVMLIV | KIVQPELKSL | ALGFHSMVIR | ALGGILAPIY | FGALIDTTCI | 
    650:
    KWSTNNCGTR | GSCRTYNSTS | FSRVYLGLSS | MLRVSSLVLY | IILIYAMKKK | 
    691:
    YQEKDINASE | NGSVMDEANL | ESLNKNKHFV | PSAGADSETH | C
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Hs.449738
    KEGG:
    hsa:10599
    Pfam:
    PF07648
    MIM:
    237450
    MIM:
    604843
    String:
    Q9Y6L6
    STRING:
    9606.ENSP00000256958
    SMR:
    Q9Y6L6
    Uniprot:
    Q9Y6L6
     
    FOR
    ELISA Kit for Human Solute carrier organic anion transporter family member 1B1
    CLIA Kit for Human Solute carrier organic anion transporter family member 1B1
    Polyclonal Antibody for Human Solute carrier organic anion transporter family member 1B1
    Monoclonal Antibody for Human Solute carrier organic anion transporter family member 1B1
    Protein for Human Solute carrier organic anion transporter family member 1B1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1."
      Abe T. , Kakyo M. , Tokui T. , Nakagomi R. , Nishio T. , Nakai D. , Nomura H. , Unno M. , Suzuki M. , Naitoh T. , Matsuno S. , Yawo H.
      J. Biol. Chem.274:17159-17163(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;VARIANTS LYS-152 AND ASN-241
      tissue: Liver.
    2. 2.
      "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters."
      Hsiang B.H. , Zhu Y. , Wang Z. , Wu Y. , Sasseville V. , Yang W.-P. , Kirchgessner T.G.
      J. Biol. Chem.274:37161-37168(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;VARIANT ASP-130
      tissue: Liver.
    3. 3.
      "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane."
      Koenig J. , Cui Y. , Nies A.T. , Keppler D.
      Am. J. Physiol.278:G156-G164(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    4. 4.
      Nezu J.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    5. 5.
      "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
      Koenig J. , Cui Y. , Nies A.T. , Keppler D.
      J. Biol. Chem.275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASP-130
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary gland.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ASP-130 AND THR-155
    10. 10.
      "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
      van de Steeg E. , Stranecky V. , Hartmannova H. , Noskova L. , Hrebicek M. , Wagenaar E. , van Esch A. , de Waart D.R. , Oude Elferink R.P. , Kenworthy K.E. , Sticova E. , al-Edreesi M. , Knisely A.S. , Kmoch S. , Jirsa M. , Schinkel A.H.
      J. Clin. Invest.122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INVOLVEMENT IN HBLRR
    11. 11.
      "N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1."
      Yao J. , Hong W. , Huang J. , Zhan K. , Huang H. , Hong M.
      PLoS ONE7:E52563-E52563(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516
    12. 12.
      "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans."
      Tirona R.G. , Leake B.F. , Merino G. , Kim R.B.
      J. Biol. Chem.276:35669-35675(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174; ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667;CHARACTERIZATION
    13. 13.
      "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter."
      Michalski C. , Cui Y. , Nies A.T. , Nuessler A.K. , Neuhaus P. , Zanger U.M. , Klein K. , Eichelbaum M. , Keppler D. , Koenig J.
      J. Biol. Chem.277:43058-43063(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193;FUNCTION;SUBCELLULAR LOCATION
    14. 14.
      "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis."
      Nozawa T. , Nakajima M. , Tamai I. , Noda K. , Nezu J. , Sai Y. , Tsuji A. , Yokoi T.
      J. Pharmacol. Exp. Ther.302:804-813(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241
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