Gene name:
SLCO4C1 (OATP4C1;OATPX;SLC21A20) ;
Protein name:
Solute carrier organic anion transporter family member 4C1 ;
Alternative:
Organic anion transporter M1 (OATP-M1) ;OATP-H ;Solute carrier family 21 member 20 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
Subcellular Location:
Basolateral cell membrane
Multi-pass membrane protein
Detected at the basolateral membrane of the proximal tubule cell in the kidney.
Protein Attributes:
50:
MKSAKGIENL | AFVPSSPDIL | RRLSASPSQI | EVSALSSDPQ | RENSQPQELQ |
100:
KPQEPQKSPE | PSLPSAPPNV | SEEKLRSLSL | SEFEEGSYGW | RNFHPQCLQR |
150:
CNTPGGFLLH | YCLLAVTQGI | VVNGLVNISI | STVEKRYEMK | SSLTGLISSS |
200:
YDISFCLLSL | FVSFFGERGH | KPRWLAFAAF | MIGLGALVFS | LPQFFSGEYK |
250:
LGSLFEDTCV | TTRNSTSCTS | STSSLSNYLY | VFILGQLLLG | AGGTPLYTLG |
300:
TAFLDDSVPT | HKSSLYIGTG | YAMSILGPAI | GYVLGGQLLT | IYIDVAMGES |
350:
TDVTEDDPRW | LGAWWIGFLL | SWIFAWSLII | PFSCFPKHLP | GTAEIQAGKT |
400:
SQAHQSNSNA | DVKFGKSIKD | FPAALKNLMK | NAVFMCLVLS | TSSEALITTG |
450:
FATFLPKFIE | NQFGLTSSFA | ATLGGAVLIP | GAALGQILGG | FLVSKFRMTC |
500:
KNTMKFALFT | SGVALTLSFV | FMYAKCENEP | FAGVSESYNG | TGELGNLIAP |
550:
CNANCNCSRS | YYYPVCGDGV | QYFSPCFAGC | SNPVAHRKPK | VYYNCSCIER |
600:
KTEITSTAET | FGFEAKAGKC | ETHCAKLPIF | LCIFFIVIIF | TFMAGTPITV |
650:
SILRCVNHRQ | RSLALGIQFM | VLRLLGTIPG | PIIFGFTIDS | TCILWDINDC |
700:
GIKGACWIYD | NIKMAHMLVA | ISVTCKVITM | FFNGFAIFLY | KPPPSATDVS |
724:
FHKENAVVTN | VLAEQDLNKI | VKEG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
Protein for Human Solute carrier organic anion transporter family member 4C1
Protein for Human Solute carrier organic anion transporter family member 4C1
Protein for Human Solute carrier organic anion transporter family member 4C1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;INHIBITION
tissue :
Kidney .
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"Cloning and characterization of two novel OATP genes on human 5q21.1."
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Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Trachea .
4.
Mural R.J.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION