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Index > Protein center > SLCO4C1(Gene name) > Human
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  • SLCO4C1 (Gene name),
  • Solute carrier organic anion transporter family member 4C1 (Protein name ),  SO4C1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLCO4C1(OATP4C1;OATPX;SLC21A20);
    Protein name:
    Solute carrier organic anion transporter family member 4C1;
    Alternative:
    Organic anion transporter M1(OATP-M1);OATP-H;Solute carrier family 21 member 20;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
    Subcellular Location:
    Basolateral cell membrane Multi-pass membrane protein Detected at the basolateral membrane of the proximal tubule cell in the kidney.
    Protein Attributes:
    Sequence length:
    724
    Sequence:
    50:
    MKSAKGIENL | AFVPSSPDIL | RRLSASPSQI | EVSALSSDPQ | RENSQPQELQ | 
    100:
    KPQEPQKSPE | PSLPSAPPNV | SEEKLRSLSL | SEFEEGSYGW | RNFHPQCLQR | 
    150:
    CNTPGGFLLH | YCLLAVTQGI | VVNGLVNISI | STVEKRYEMK | SSLTGLISSS | 
    200:
    YDISFCLLSL | FVSFFGERGH | KPRWLAFAAF | MIGLGALVFS | LPQFFSGEYK | 
    250:
    LGSLFEDTCV | TTRNSTSCTS | STSSLSNYLY | VFILGQLLLG | AGGTPLYTLG | 
    300:
    TAFLDDSVPT | HKSSLYIGTG | YAMSILGPAI | GYVLGGQLLT | IYIDVAMGES | 
    350:
    TDVTEDDPRW | LGAWWIGFLL | SWIFAWSLII | PFSCFPKHLP | GTAEIQAGKT | 
    400:
    SQAHQSNSNA | DVKFGKSIKD | FPAALKNLMK | NAVFMCLVLS | TSSEALITTG | 
    450:
    FATFLPKFIE | NQFGLTSSFA | ATLGGAVLIP | GAALGQILGG | FLVSKFRMTC | 
    500:
    KNTMKFALFT | SGVALTLSFV | FMYAKCENEP | FAGVSESYNG | TGELGNLIAP | 
    550:
    CNANCNCSRS | YYYPVCGDGV | QYFSPCFAGC | SNPVAHRKPK | VYYNCSCIER | 
    600:
    KTEITSTAET | FGFEAKAGKC | ETHCAKLPIF | LCIFFIVIIF | TFMAGTPITV | 
    650:
    SILRCVNHRQ | RSLALGIQFM | VLRLLGTIPG | PIIFGFTIDS | TCILWDINDC | 
    700:
    GIKGACWIYD | NIKMAHMLVA | ISVTCKVITM | FFNGFAIFLY | KPPPSATDVS | 
    724:
    FHKENAVVTN | VLAEQDLNKI | VKEG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
    ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
    ELISA Kit for Human Solute carrier organic anion transporter family member 4C1
    CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
    CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
    CLIA Kit for Human Solute carrier organic anion transporter family member 4C1
    Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Polyclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Monoclonal Antibody for Human Solute carrier organic anion transporter family member 4C1
    Protein for Human Solute carrier organic anion transporter family member 4C1
    Protein for Human Solute carrier organic anion transporter family member 4C1
    Protein for Human Solute carrier organic anion transporter family member 4C1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney."
      Mikkaichi T. , Suzuki T. , Onogawa T. , Tanemoto M. , Mizutamari H. , Okada M. , Chaki T. , Masuda S. , Tokui T. , Eto N. , Abe M. , Satoh F. , Unno M. , Hishinuma T. , Inui K. , Ito S. , Goto J. , Abe T.
      Proc. Natl. Acad. Sci. U.S.A.101:3569-3574(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;INHIBITION
      tissue: Kidney.
    2. 2.
      "Cloning and characterization of two novel OATP genes on human 5q21.1."
      Fu-Zhang W.
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein."
      Chu X.-Y. , Bleasby K. , Yabut J. , Cai X. , Chan G.H. , Hafey M.J. , Xu S. , Bergman A.J. , Braun M.P. , Dean D.C. , Evers R.
      J. Pharmacol. Exp. Ther.321:673-683(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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