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Index > Protein center > Sost(Gene name) > Mouse
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  • Sost (Gene name),
  • Sclerostin (Protein name ),  SOST_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Sost;
    Protein name:
    Sclerostin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling.
    Function:
    Negative regulator of bone growth.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    211
    Sequence:
    50:
    MQPSLAPCLI | CLLVHAAFCA | VEGQGWQAFR | NDATEVIPGL | GEYPEPPPEN | 
    100:
    NQTMNRAENG | GRPPHHPYDA | KGVSEYSCRE | LHYTRFLTDG | PCRSAKPVTE | 
    150:
    LVCSGQCGPA | RLLPNAIGRV | KWWRPNGPDF | RCIPDRYRAQ | RVQLLCPGGA | 
    200:
    APRSRKVRLV | ASCKCKRLTR | FHNQSELKDF | GPETARPQKG | RKPRPGARGA | 
    211:
    KANQAELENA | Y
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Sclerostin
    Cat.:
    E1713r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Sclerostin
    Cat.:
    E1713m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Sclerostin
    Cat.:
    E1713h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Sclerostin
    Cat.:
    E1713b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Sclerostin
    Cat.:
    U1713r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Sclerostin
    Cat.:
    U1713b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Sclerostin
    Cat.:
    U1713m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Sclerostin
    Cat.:
    U1713h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Sclerostin
    Polyclonal Antibody for Mouse Sclerostin
    Cat.:
    P1713Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Sclerostin
    Cat.:
    P1713Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Sclerostin
    Cat.:
    P1713Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Sclerostin
    Monoclonal Antibody for Mouse Sclerostin
    Monoclonal Antibody for Mouse Sclerostin
    Monoclonal Antibody for Mouse Sclerostin
    Protein for Mouse Sclerostin
    Protein for Mouse Sclerostin
    Protein for Mouse Sclerostin
    Protein for Mouse Sclerostin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein."
      Brunkow M.E. , Gardner J.C. , Van Ness J. , Paeper B.W. , Kovacevich B.R. , Proll S. , Skonier J.E. , Zhao L. , Sabo P.J. , Fu Y.H. , Alisch R.S. , Gillett L. , Colbert T. , Tacconi P. , Galas D. , Hamersma H. , Beighton P. , Mulligan J.T.
      Am. J. Hum. Genet.68:577-589(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      strain: 129/SvJ.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Head.
    3. 3.
      "Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling."
      Li X. , Zhang Y. , Kang H. , Liu W. , Liu P. , Zhang J. , Harris S.E. , Wu D.
      J. Biol. Chem.280:19883-19887(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP5 AND LRP6
    4. 4.
      "Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling."
      Lin C. , Jiang X. , Dai Z. , Guo X. , Weng T. , Wang J. , Li Y. , Feng G. , Gao X. , He L.
      J. Bone Miner. Res.24:1651-1661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 59-167;DISULFIDE BONDS
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