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Index > Protein center > SERPINB4(Gene name) > Human
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  • SERPINB4 (Gene name),
  • Serpin B4 (Protein name ),  SPB4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SERPINB4(PI11;SCCA2);
    Protein name:
    Serpin B4;
    Alternative:
    Peptidase inhibitor 11(PI-11);Leupin;Squamous cell carcinoma antigen 2(SCCA-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May act as a protease inhibitor to modulate the host immune response against tumor cells.
    Subcellular Location:
    Cytoplasm Seems to also be secreted in plasma by cancerous cells but at a low level.
    Protein Attributes:
    Sequence length:
    390
    Sequence:
    50:
    MNSLSEANTK | FMFDLFQQFR | KSKENNIFYS | PISITSALGM | VLLGAKDNTA | 
    100:
    QQISKVLHFD | QVTENTTEKA | ATYHVDRSGN | VHHQFQKLLT | EFNKSTDAYE | 
    150:
    LKIANKLFGE | KTYQFLQEYL | DAIKKFYQTS | VESTDFANAP | EESRKKINSW | 
    200:
    VESQTNEKIK | NLFPDGTIGN | DTTLVLVNAI | YFKGQWENKF | KKENTKEEKF | 
    250:
    WPNKNTYKSV | QMMRQYNSFN | FALLEDVQAK | VLEIPYKGKD | LSMIVLLPNE | 
    300:
    IDGLQKLEEK | LTAEKLMEWT | SLQNMRETCV | DLHLPRFKME | ESYDLKDTLR | 
    350:
    TMGMVNIFNG | DADLSGMTWS | HGLSVSKVLH | KAFVEVTEEG | VEAAAATAVV | 
    390:
    VVELSSPSTN | EEFCCNHPFL | FFIRQNKTNS | ILFYGRFSSP | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serpin B4
    Cat.:
    E0159h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Serpin B4
    Cat.:
    U0159h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Serpin B4
    Cat.:
    P0159Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Serpin B4
    Protein for Human Serpin B4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a novel human serpin gene; cloning sequencing and expression of leupin."
      Barnes R.C. , Worrall D.M.
      FEBS Lett.373:61-65(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
      Schneider S.S. , Schick C. , Fish K.E. , Miller E. , Pena J.C. , Treter S.D. , Hui S.M. , Silverman G.A.
      Proc. Natl. Acad. Sci. U.S.A.92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    3. 3.
      "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter."
      Hamada K. , Shinomiya H. , Asano Y. , Kihana T. , Iwamoto M. , Hanakawa Y. , Hashimoto K. , Hirose S. , Kyo S. , Ito M.
      Biochim. Biophys. Acta1518:124-131(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Esophagus.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    6. 6.
      Bienvenut W.V. , Bensaad K. , Vousden K.H.
      Submitted (2008-02) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-21; 56-69; 88-94; 147-160; 215-260; 266-276 AND 378-386;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Osteosarcoma.
    7. 7.
      "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."
      Uemura Y. , Pak S.C. , Luke C. , Cataltepe S. , Tsu C. , Schick C. , Kamachi Y. , Pomeroy S.L. , Perlmutter D.H. , Silverman G.A.
      Int. J. Cancer89:368-377(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
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