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Index > Protein center > SPON2(Gene name) > Human
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  • SPON2 (Gene name),
  • Spondin-2 (Protein name ),  SPON2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    SPON2(UNQ435/PRO866;DIL1);
    Protein name:
    Spondin-2;
    Alternative:
    Mindin;Differentially expressed in cancerous and non-cancerous lung cells 1(DIL-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with integrin.
    Function:
    Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    331
    Sequence:
    50:
    MENPSPAAAL | GKALCALLLA | TLGAAGQPLG | GESICSARAL | AKYSITFTGK | 
    100:
    WSQTAFPKQY | PLFRPPAQWS | SLLGAAHSSD | YSMWRKNQYV | SNGLRDFAER | 
    150:
    GEAWALMKEI | EAAGEALQSV | HEVFSAPAVP | SGTGQTSAEL | EVQRRHSLVS | 
    200:
    FVVRIVPSPD | WFVGVDSLDL | CDGDRWREQA | ALDLYPYDAG | TDSGFTFSSP | 
    250:
    NFATIPQDTV | TEITSSSPSH | PANSFYYPRL | KALPPIARVT | LVRLRQSPRA | 
    300:
    FIPPAPVLPS | RDNEIVDSAS | VPETPLDCEV | SLWSSWGLCG | GHCGRLGTKS | 
    331:
    RTRYVRVQPA | NNGSPCPELE | EEAECVPDNC | V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Spondin-2
    Cat.:
    E0378h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Spondin-2
    Cat.:
    E0378m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Spondin-2
    Cat.:
    E0378r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Spondin-2
    Cat.:
    U0378r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Spondin-2
    Cat.:
    U0378m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Spondin-2
    Cat.:
    U0378h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Spondin-2
    Cat.:
    P0378Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Spondin-2
    Cat.:
    P0378Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Spondin-2
    Cat.:
    P0378Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Spondin-2
    Monoclonal Antibody for Human Spondin-2
    Monoclonal Antibody for Human Spondin-2
    Protein for Human Spondin-2
    Protein for Human Spondin-2
    Protein for Human Spondin-2

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    References
    1. 1.
      "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display."
      Manda R. , Kohno T. , Matsuno Y. , Takenoshita S. , Kuwano H. , Yokota J.
      Genomics61:5-14(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANTS PRO-40 AND ALA-122
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-40 AND LEU-242
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-40; ALA-122 AND LEU-242
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-122
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS PRO-40; ALA-122 AND LEU-242
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-40 AND LEU-242
      tissue: Colon.
      tissue: Placenta.
    7. 7.
      "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule."
      Li Y. , Cao C. , Jia W. , Yu L. , Mo M. , Wang Q. , Huang Y. , Lim J.-M. , Ishihara M. , Wells L. , Azadi P. , Robinson H. , He Y.-W. , Zhang L. , Mariuzza R.A.
      EMBO J.28:286-297(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 27-249 IN COMPLEX WITH METAL IONS;PARTIAL PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT;GLYCOSYLATION AT TRP-283;INTERACTION WITH INTEGRIN AND BACTERIAL LIPOPOLYSACCHARIDE;MUTAGENESIS OF GLU-122 AND GLU-141;DISULFIDE BOND
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