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Index > Protein center > Spz1(Gene name) > Mouse
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  • Spz1 (Gene name),
  • Spermatogenic leucine zipper protein 1 (Protein name ),  SPZ1_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Spz1;
    Protein name:
    Spermatogenic leucine zipper protein 1;
    Alternative:
    Spermatogenic Zip 1;BHLH-Zip transcription factor SPZ1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PPP1CC isoform gamma-2. This interaction can prevent SPZ1 binding to the E-box and inhibits PPP1CC activity.
    Function:
    Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    378
    Sequence:
    50:
    MSDTDNSAEM | PARCPSPNPA | PGAKQEPPNS | GITISLLEIG | SLPTVCYHSF | 
    100:
    PPPKNSICPV | EKRGRVQKFS | NLLKDVKDVL | KNIAGVEEKS | TVGEPFDDAY | 
    150:
    IPEDLSELNV | RGVEKKNKIR | FKDDLFIHFD | PEREQNTMKQ | MLLKNQSAKN | 
    200:
    MVPKFARDLC | NAEETRGFDG | MLLSVKRPRN | GSLHLRGEYR | KLRNNMEQLL | 
    250:
    QEADHWSKQH | NELSELMRSY | QECQNETQET | TDKDRACLQN | QPNNGLSTKQ | 
    300:
    KLEEQVKKLS | HDTHALHLIA | ALLENECQVL | QQRVDILKDF | HLHEAGLGHE | 
    350:
    KPLQMSCEQD | KKCPKLAEAD | KTDAFKHTTR | ATEGTIRKPK | ILRSPDVCFT | 
    378:
    KKARNNRFNA | RVAKKSLVGK | RRTVSSFR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Spermatogenic leucine zipper protein 1
    ELISA Kit for Mouse Spermatogenic leucine zipper protein 1
    ELISA Kit for Mouse Spermatogenic leucine zipper protein 1
    ELISA Kit for Mouse Spermatogenic leucine zipper protein 1
    CLIA Kit for Mouse Spermatogenic leucine zipper protein 1
    CLIA Kit for Mouse Spermatogenic leucine zipper protein 1
    CLIA Kit for Mouse Spermatogenic leucine zipper protein 1
    CLIA Kit for Mouse Spermatogenic leucine zipper protein 1
    Polyclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Polyclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Polyclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Polyclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Monoclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Monoclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Monoclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Monoclonal Antibody for Mouse Spermatogenic leucine zipper protein 1
    Protein for Mouse Spermatogenic leucine zipper protein 1
    Protein for Mouse Spermatogenic leucine zipper protein 1
    Protein for Mouse Spermatogenic leucine zipper protein 1
    Protein for Mouse Spermatogenic leucine zipper protein 1

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    References
    1. 1.
      "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis."
      Hsu S.-H. , Shyu H.-W. , Hsieh-Li H.-M. , Li H.
      Mech. Dev.100:177-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION;DEVELOPMENTAL STAGE
      strain: C57BL/6J.
      tissue: Testis.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 4.
      "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis."
      Hrabchak C. , Varmuza S.
      J. Biol. Chem.279:37079-37086(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PPP1CC ISOFORM GAMMA-2
    5. 5.
      "Dysfunctional spermatogenesis in transgenic mice overexpressing bHLH-Zip transcription factor, Spz1."
      Hsu S.-H. , Hsieh-Li H.-M. , Li H.
      Exp. Cell Res.294:185-198(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 6.
      "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis."
      Hsu S.-H. , Hsieh-Li H.-M. , Huang H.-Y. , Huang P.-H. , Li H.
      Cancer Res.65:4041-4050(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION
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