Protein name:
STAM-binding protein ;
Alternative:
Associated molecule with the SH3 domain of STAM ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3 (By similarity). Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination.
Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of AMSH is required for efficient EGFR degradation but not for its internalization. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Subcellular Location:
Nucleus
Membrane
Peripheral membrane protein
Cytoplasm
Endosome
Protein Attributes:
50:
MSDHADVSLP | PQDRVRILSQ | LGSAVELNED | IPPRRYFRSG | VEIIRMASIY |
100:
SEEGNIEHAF | ILYNKYITLF | IEKLPKHRDY | KSAIIPEKKD | AVKKLKNVAF |
150:
PKAEELKTEL | LKRYTKEYEQ | YKERKKKEEE | ELARNIAIQQ | ELEKEKQRVA |
200:
QQKQKQLEQE | QFHAFEKMIQ | KQELEKERLK | IVQEFGKVDP | GPCGPLLPDL |
250:
EKPCVDVAPS | SPFSPTQTSD | CNTTLRPAKP | PVVDRSLKPG | ALSVIENVPT |
300:
IEGLRHIVVP | RNLCSEFLQL | ASANTAKGIE | TCGVLCGKLM | RNEFTITHVL |
350:
IPRQNGGPDY | CHTENEEEIF | FMQDDLGLLT | LGWIHTHPTQ | TAFLSSVDLH |
400:
THCSYQMMLP | ESIAIVCSPK | FQETGFFKLT | DYGLQEISTC | RQKGFHPHGR |
424:
DPPLFCDCSH | VTVKDRIVTI | TDLR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat STAM-binding protein
ELISA Kit for Rat STAM-binding protein
ELISA Kit for Rat STAM-binding protein
CLIA Kit for Rat STAM-binding protein
CLIA Kit for Rat STAM-binding protein
CLIA Kit for Rat STAM-binding protein
Polyclonal Antibody for Rat STAM-binding protein
Polyclonal Antibody for Rat STAM-binding protein
Polyclonal Antibody for Rat STAM-binding protein
Monoclonal Antibody for Rat STAM-binding protein
Monoclonal Antibody for Rat STAM-binding protein
Monoclonal Antibody for Rat STAM-binding protein
Protein for Rat STAM-binding protein
Protein for Rat STAM-binding protein
Protein for Rat STAM-binding protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Prostate .