STEAP4 ELISA Kit for Human(Homo sapiens) | EIAab.comSTEAP4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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STEAP4 (Gene name),

Metalloreductase STEAP4 (Protein name ), STEA4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

STEAP4(STAMP2;TNFAIP9);

Protein name:

Metalloreductase STEAP4;

Alternative:

SixTransMembrane protein of prostate 2;Six-transmembrane epithelial antigen of prostate 4;Tumor necrosis factor, alpha-induced protein 9;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with and phosphorylates PTK2.

Function:

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

Subcellular Location:

Cell membrane Golgi apparatus membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

459

Sequence:

50:

MEKTCIDALP | LTMNSSEKQE | TVCIFGTGDF | GRSLGLKMLQ | CGYSVVFGSR |

100:

NPQKTTLLPS | GAEVLSYSEA | AKKSGIIIIA | IHREHYDFLT | ELTEVLNGKI |

150:

LVDISNNLKI | NQYPESNAEY | LAHLVPGAHV | VKAFNTISAW | ALQSGALDAS |

200:

RQVFVCGNDS | KAKQRVMDIV | RNLGLTPMDQ | GSLMAAKEIE | KYPLQLFPMW |

250:

RFPFYLSAVL | CVFLFFYCVI | RDVIYPYVYE | KKDNTFRMAI | SIPNRIFPIT |

300:

ALTLLALVYL | PGVIAAILQL | YRGTKYRRFP | DWLDHWMLCR | KQLGLVALGF |

350:

AFLHVLYTLV | IPIRYYVRWR | LGNLTVTQAI | LKKENPFSTS | SAWLSDSYVA |

400:

LGILGFFLFV | LLGITSLPSV | SNAVNWREFR | FVQSKLGYLT | LILCTAHTLV |

450:

YGGKRFLSPS | NLRWYLPAAY | VLGLIIPCTV | LVIKFVLIMP | CVDNTLTRIR |

459:

QGWERNSKH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000369419

SMR:

MIM:

Pfam:

UniGene:

String:

KEGG:

Pfam:

Uniprot:

FOR

ELISA Kit for Human Metalloreductase STEAP4

ELISA Kit for Human Metalloreductase STEAP4

ELISA Kit for Human Metalloreductase STEAP4

CLIA Kit for Human Metalloreductase STEAP4

CLIA Kit for Human Metalloreductase STEAP4

CLIA Kit for Human Metalloreductase STEAP4

Polyclonal Antibody for Human Metalloreductase STEAP4

Polyclonal Antibody for Human Metalloreductase STEAP4

Polyclonal Antibody for Human Metalloreductase STEAP4

Monoclonal Antibody for Human Metalloreductase STEAP4

Monoclonal Antibody for Human Metalloreductase STEAP4

Monoclonal Antibody for Human Metalloreductase STEAP4

Protein for Human Metalloreductase STEAP4

Protein for Human Metalloreductase STEAP4

Protein for Human Metalloreductase STEAP4

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer."
Korkmaz C.G. , Korkmaz K.S. , Kurys P. , Elbi C. , Wang L. , Klokk T.I. , Hammarstrom C. , Troen G. , Svindland A. , Hager G.L. , Saatcioglu F.
Oncogene24:4934-4945(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY
tissue: Prostatic carcinoma.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-75
tissue: Lung.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Lung.
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 325-459
tissue: Stomach.
5.

"Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells."
Ohgami R.S. , Campagna D.R. , Greer E.L. , Antiochos B. , McDonald A. , Chen J. , Sharp J.J. , Fujiwara Y. , Barker J.E. , Fleming M.D.
Nat. Genet.37:1264-1269(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans."
Zhang C.M. , Chi X. , Wang B. , Zhang M. , Ni Y.H. , Chen R.H. , Li X.N. , Guo X.R.
Acta Pharmacol. Sin.29:587-592(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INDUCTION BY TNF
7.

"Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance."
Arner P. , Stenson B.M. , Dungner E. , Naeslund E. , Hoffstedt J. , Ryden M. , Dahlman I.
J. Clin. Endocrinol. Metab.93:2249-2254(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
8.

"Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis."
Inoue A. , Matsumoto I. , Tanaka Y. , Iwanami K. , Kanamori A. , Ochiai N. , Goto D. , Ito S. , Sumida T.
Arthritis Res. Ther.11:R118-R118(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro."
Kralisch S. , Sommer G. , Weise S. , Lipfert J. , Lossner U. , Kamprad M. , Schrock K. , Bluher M. , Stumvoll M. , Fasshauer M.
FEBS Lett.583:1196-1200(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY IL1B;TISSUE SPECIFICITY
10.

"STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells."
Tamura T. , Chiba J.
Int. J. Mol. Med.24:599-604(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PTK2/FAK1;SUBCELLULAR LOCATION
11.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323
tissue: Liver.

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