STIL ELISA Kit for Human(Homo sapiens) | EIAab.comSTIL ELISA Kit for Human(Homo sapiens)

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Index > Protein center > STIL(Gene name) > Human

STIL (Gene name),

SCL-interrupting locus protein (Protein name ), STIL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

STIL(SIL);

Protein name:

SCL-interrupting locus protein;

Alternative:

TAL-1-interrupting locus protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation.

Function:

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Play a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.

Subcellular Location:

Cytoplasm cytosol

Protein Attributes:

Sequence length:

1287

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1287:

IFPESLQPSE | TLKQMNSMNS | VGTFLDVKRL | RQLPKLF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.525198

KEGG:

hsa:6491

String:

Q15468

STRING:

9606.ENSP00000360944

MIM:

181590

Uniprot:

Q15468

FOR

ELISA Kit for Human SCL-interrupting locus protein

Cat.:

E3405h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human SCL-interrupting locus protein

Cat.:

E3405m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human SCL-interrupting locus protein

Cat.:

U3405m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human SCL-interrupting locus protein

Cat.:

U3405h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human SCL-interrupting locus protein

Cat.:

P3405Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human SCL-interrupting locus protein

Cat.:

P3405Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human SCL-interrupting locus protein

Protein for Human SCL-interrupting locus protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia."
Aplan P.D. , Lombardi D.P. , Kirsch I.R.
Mol. Cell. Biol.11:5462-5469(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHROMOSOMAL REARRANGEMENT;TISSUE SPECIFICITY
tissue: Bone marrow.
2.

"The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly."
Karkera J.D. , Izraeli S. , Roessler E. , Dutra A. , Kirsch I.R. , Muenke M.
Cytogenet. Genome Res.97:62-67(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1);VARIANTS VAL-86 AND ARG-1012
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS VAL-86 AND ARG-984
tissue: Uterus.
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia."
Brown L. , Cheng J.-T. , Chen Q. , Siciliano M.J. , Crist W. , Buchanan G. , Baer R.
EMBO J.9:3343-3351(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
7.

"Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity."
Aplan P.D. , Lombardi D.P. , Ginsberg A.M. , Cossman J. , Bertness V.L. , Kirsch I.R.
Science250:1426-1429(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
8.

"Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia."
Aplan P.D. , Lombardi D.P. , Reaman G.H. , Sather H.N. , Hammond G.D. , Kirsch I.R.
Blood79:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
9.

"Expression of the SIL gene is correlated with growth induction and cellular proliferation."
Izraeli S. , Colaizzo-Anas T. , Bertness V.L. , Mani K. , Aplan P.D. , Kirsch I.R.
Cell Growth Differ.8:1171-1179(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
10.

"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints."
Raghavan S.C. , Kirsch I.R. , Lieber M.R.
J. Biol. Chem.276:29126-29133(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
11.

"Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR."
Curry J.D. , Smith M.T.
Leuk. Res.27:575-582(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
12.

"Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951."
Cave H. , Suciu S. , Preudhomme C. , Poppe B. , Robert A. , Uyttebroeck A. , Malet M. , Boutard P. , Benoit Y. , Mauvieux L. , Lutz P. , Mechinaud F. , Grardel N. , Mazingue F. , Dupont M. , Margueritte G. , Pages M.-P. , Bertrand Y. , more...
Blood103:442-450(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
13.

"Sil overexpression in lung cancer characterizes tumors with increased mitotic activity."
Erez A. , Perelman M. , Hewitt S.M. , Cojacaru G. , Goldberg I. , Shahar I. , Yaron P. , Muler I. , Campaner S. , Amariglio N. , Rechavi G. , Kirsch I.R. , Krupsky M. , Kaminski N. , Izraeli S.
Oncogene23:5371-5377(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint."
Campaner S. , Kaldis P. , Izraeli S. , Kirsch I.R.
Mol. Cell. Biol.25:6660-6672(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
15.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly."
Kumar A. , Girimaji S.C. , Duvvari M.R. , Blanton S.H.
Am. J. Hum. Genet.84:286-290(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MCPH7
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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