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Index > Protein center > Sumo1(Gene name) > Mouse
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  • Sumo1 (Gene name),
  • Small ubiquitin-related modifier 1 (Protein name ),  SUMO1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Sumo1(Smt3c;Smt3h3;Ubl1);
    Protein name:
    Small ubiquitin-related modifier 1(SUMO-1);
    Alternative:
    Ubiquitin-homology domain protein PIC1;SMT3 homolog 3;Ubiquitin-like protein SMT3C(Smt3C);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with USP25 (via ts SIM domain) the interaction weakly sumoylates USP25 (By similarity). Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52.
    Function:
    Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.
    Subcellular Location:
    Nucleus membrane Nucleus speckle Cytoplasm Recruited by BCL11A into the nuclear body.
    Protein Attributes:
    Sequence length:
    101
    Sequence:
    50:
    MSDQEAKPST | EDLGDKKEGE | YIKLKVIGQD | SSEIHFKVKM | TTHLKKLKES | 
    100:
    YCQRQGVPMN | SLRFLFEGQR | IADNHTPKEL | GMEEEDVIEV | YQEQTGGHST | 
    101:
    V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SUMO-1
    ELISA Kit for Mouse SUMO-1
    ELISA Kit for Mouse SUMO-1
    ELISA Kit for Mouse SUMO-1
    ELISA Kit for Mouse SUMO-1
    ELISA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    CLIA Kit for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Polyclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Monoclonal Antibody for Mouse SUMO-1
    Protein for Mouse SUMO-1
    Protein for Mouse SUMO-1
    Protein for Mouse SUMO-1
    Protein for Mouse SUMO-1
    Protein for Mouse SUMO-1
    Protein for Mouse SUMO-1

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    References
    1. 1.
      "The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes."
      Howe K. , Williamson J. , Boddy M.N. , Sheer D. , Freemont P.S. , Solomon E.
      Genomics47:92-100(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: ICR.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Kidney.
      tissue: Liver.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Colon.
      tissue: Eye.
    4. 4.
      "Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo."
      Shao R. , Zhang F.-P. , Tian F. , Anders Friberg P. , Wang X. , Sjoeland H. , Billig H.
      FEBS Lett.569:293-300(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION;INTERACTION WITH HIF1A
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKFZ1
    6. 6.
      "SUMO1 haploinsufficiency leads to cleft lip and palate."
      Alkuraya F.S. , Saadi I. , Lund J.J. , Turbe-Doan A. , Morton C.C. , Maas R.L.
      Science313:1751-1751(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
    7. 7.
      "BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body."
      Kuwata T. , Nakamura T.
      Genes Cells13:931-940(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 8.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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