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Index > Protein center > SV2A(Gene name) > Human
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  • SV2A (Gene name),
  • Synaptic vesicle glycoprotein 2A (Protein name ),  SV2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    SV2A(PSEC0174;KIAA0736);
    Protein name:
    Synaptic vesicle glycoprotein 2A;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.
    Function:
    Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Multi-pass membrane protein Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
    Protein Attributes:
    Sequence length:
    742
    Sequence:
    50:
    MEEGFRDRAA | FIRGAKDIAK | EVKKHAAKKV | VKGLDRVQDE | YSRRSYSRFE | 
    100:
    EEDDDDDFPA | PSDGYYRGEG | TQDEEEGGAS | SDATEGHDED | DEIYEGEYQG | 
    150:
    IPRAESGGKG | ERMADGAPLA | GVRGGLSDGE | GPPGGRGEAQ | RRKEREELAQ | 
    200:
    QYEAILRECG | HGRFQWTLYF | VLGLALMADG | VEVFVVGFVL | PSAEKDMCLS | 
    250:
    DSNKGMLGLI | VYLGMMVGAF | LWGGLADRLG | RRQCLLISLS | VNSVFAFFSS | 
    300:
    FVQGYGTFLF | CRLLSGVGIG | GSIPIVFSYF | SEFLAQEKRG | EHLSWLCMFW | 
    350:
    MIGGVYAAAM | AWAIIPHYGW | SFQMGSAYQF | HSWRVFVLVC | AFPSVFAIGA | 
    400:
    LTTQPESPRF | FLENGKHDEA | WMVLKQVHDT | NMRAKGHPER | VFSVTHIKTI | 
    450:
    HQEDELIEIQ | SDTGTWYQRW | GVRALSLGGQ | VWGNFLSCFG | PEYRRITLMM | 
    500:
    MGVWFTMSFS | YYGLTVWFPD | MIRHLQAVDY | ASRTKVFPGE | RVEHVTFNFT | 
    550:
    LENQIHRGGQ | YFNDKFIGLR | LKSVSFEDSL | FEECYFEDVT | SSNTFFRNCT | 
    600:
    FINTVFYNTD | LFEYKFVNSR | LINSTFLHNK | EGCPLDVTGT | GEGAYMVYFV | 
    650:
    SFLGTLAVLP | GNIVSALLMD | KIGRLRMLAG | SSVMSCVSCF | FLSFGNSESA | 
    700:
    MIALLCLFGG | VSIASWNALD | VLTVELYPSD | KRTTAFGFLN | ALCKLAAVLG | 
    742:
    ISIFTSFVGI | TKAAPILFAS | AALALGSSLA | LKLPETRGQV | LQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Synaptic vesicle glycoprotein 2A
    ELISA Kit for Human Synaptic vesicle glycoprotein 2A
    ELISA Kit for Human Synaptic vesicle glycoprotein 2A
    ELISA Kit for Human Synaptic vesicle glycoprotein 2A
    CLIA Kit for Human Synaptic vesicle glycoprotein 2A
    CLIA Kit for Human Synaptic vesicle glycoprotein 2A
    CLIA Kit for Human Synaptic vesicle glycoprotein 2A
    CLIA Kit for Human Synaptic vesicle glycoprotein 2A
    Polyclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Polyclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Polyclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Polyclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Monoclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Monoclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Monoclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Monoclonal Antibody for Human Synaptic vesicle glycoprotein 2A
    Protein for Human Synaptic vesicle glycoprotein 2A
    Protein for Human Synaptic vesicle glycoprotein 2A
    Protein for Human Synaptic vesicle glycoprotein 2A
    Protein for Human Synaptic vesicle glycoprotein 2A

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    Precision
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      Ohara O. , Suyama M. , Nagase T. , Ishikawa K. , Kikuno R.
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Teratocarcinoma.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Retina.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Ovary.
    8. 8.
      "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam."
      Lynch B.A. , Lambeng N. , Nocka K. , Kensel-Hammes P. , Bajjalieh S.M. , Matagne A. , Fuks B.
      Proc. Natl. Acad. Sci. U.S.A.101:9861-9866(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION AS BINDING-SITE FOR ANTIEPILEPTIC DRUG LEVETIRACETAM
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80; SER-81 AND THR-84;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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