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Index > Protein center > Sv2a(Gene name) > Mouse
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  • Sv2a (Gene name),
  • Synaptic vesicle glycoprotein 2A (Protein name ),  SV2A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Sv2a(Kiaa0736;Sv2);
    Protein name:
    Synaptic vesicle glycoprotein 2A(Synaptic vesicle protein 2;Synaptic vesicle protein 2A);
    Alternative:
    Calcium regulator SV2A;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.
    Function:
    Receptor for the botulinium neurotoxin type A/BOTA.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Multi-pass membrane protein Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
    Protein Attributes:
    Sequence length:
    742
    Sequence:
    50:
    MEEGFRDRAA | FIRGAKDIAK | EVKKHAAKKV | VKGLDRVQDE | YSRRSYSRFE | 
    100:
    EEDDDDDFPA | PADGYYRGEG | AQDEEEGGAS | SDATEGHDED | DEIYEGEYQG | 
    150:
    IPRAESGGKG | ERMADGAPLA | GVRGGLSDGE | GPPGGRGEAQ | RRKDREELAQ | 
    200:
    QYETILRECG | HGRFQWTLYF | VLGLALMADG | VEVFVVGFVL | PSAEKDMCLS | 
    250:
    DSNKGMLGLI | VYLGMMVGAF | LWGGLADRLG | RRQCLLISLS | VNSVFAFFSS | 
    300:
    FVQGYGTFLF | CRLLSGVGIG | GSIPIVFSYF | SEFLAQEKRG | EHLSWLCMFW | 
    350:
    MIGGVYAAAM | AWAIIPHYGW | SFQMGSAYQF | HSWRVFVLVC | AFPSVFAIGA | 
    400:
    LTTQPESPRF | FLENGKHDEA | WMVLKQVHDT | NMRAKGHPER | VFSVTHIKTI | 
    450:
    HQEDELIEIQ | SDTGTWYQRW | GVRALSLGGQ | VWGNFLSCFS | PEYRRITLMM | 
    500:
    MGVWFTMSFS | YYGLTVWFPD | MIRHLQAVDY | AARTKVFPGE | RVEHVTFNFT | 
    550:
    LENQIHRGGQ | YFNDKFIGLR | LKSVSFEDSL | FEECYFEDVT | SSNTFFRNCT | 
    600:
    FINTVFYNTD | LFEYKFVNSR | LVNSTFLHNK | EGCPLDVTGT | GEGAYMVYFV | 
    650:
    SFLGTLAVLP | GNIVSALLMD | KIGRLRMLAG | SSVLSCVSCF | FLSFGNSESA | 
    700:
    MIALLCLFGG | VSIASWNALD | VLTVELYPSD | KRTTAFGFLN | ALCKLAAVLG | 
    742:
    ISIFTSFVGI | TKAAPILFAS | AALALGSSLA | LKLPETRGQV | LQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Synaptic vesicle protein 2
    ELISA Kit for Mouse Synaptic vesicle protein 2
    ELISA Kit for Mouse Synaptic vesicle protein 2
    ELISA Kit for Mouse Synaptic vesicle protein 2
    CLIA Kit for Mouse Synaptic vesicle protein 2
    CLIA Kit for Mouse Synaptic vesicle protein 2
    CLIA Kit for Mouse Synaptic vesicle protein 2
    CLIA Kit for Mouse Synaptic vesicle protein 2
    Polyclonal Antibody for Mouse Synaptic vesicle protein 2
    Polyclonal Antibody for Mouse Synaptic vesicle protein 2
    Polyclonal Antibody for Mouse Synaptic vesicle protein 2
    Polyclonal Antibody for Mouse Synaptic vesicle protein 2
    Monoclonal Antibody for Mouse Synaptic vesicle protein 2
    Monoclonal Antibody for Mouse Synaptic vesicle protein 2
    Monoclonal Antibody for Mouse Synaptic vesicle protein 2
    Monoclonal Antibody for Mouse Synaptic vesicle protein 2
    Protein for Mouse Synaptic vesicle protein 2
    Protein for Mouse Synaptic vesicle protein 2
    Protein for Mouse Synaptic vesicle protein 2
    Protein for Mouse Synaptic vesicle protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release."
      Janz R. , Goda Y. , Geppert M. , Missler M. , Suedhof T.C.
      Neuron24:1003-1016(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION
      strain: 129/Sv.
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      Okazaki N. , Kikuno R. , Nagase T. , Ohara O. , Koga H.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Brain.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Eye.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "SV2 modulates the size of the readily releasable pool of secretory vesicles."
      Xu T. , Bajjalieh S.M.
      Nat. Cell Biol.3:691-698(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    8. 8.
      "Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons."
      Krizaj D. , Demarco S.J. , Johnson J. , Strehler E.E. , Copenhagen D.R.
      J. Comp. Neurol.451:1-21(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina."
      Wang M.M. , Janz R. , Belizaire R. , Frishman L.J. , Sherry D.M.
      J. Comp. Neurol.460:106-122(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    10. 10.
      "Synaptic vesicle protein 2 enhances release probability at quiescent synapses."
      Custer K.L. , Austin N.S. , Sullivan J.M. , Bajjalieh S.M.
      J. Neurosci.26:1303-1313(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "SV2 is the protein receptor for botulinum neurotoxin A."
      Dong M. , Yeh F. , Tepp W.H. , Dean C. , Johnson E.A. , Janz R. , Chapman E.R.
      Science312:592-596(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A BOTA RECEPTOR;DISRUPTION PHENOTYPE
    12. 12.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-480;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
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