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Index > Protein center > Sv2b(Gene name) > Rat
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  • Sv2b (Gene name),
  • Synaptic vesicle glycoprotein 2B (Protein name ),  SV2B_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Sv2b(Sv2bb);
    Protein name:
    Synaptic vesicle glycoprotein 2B(Synaptic vesicle protein 2B);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25.
    Function:
    Receptor for the botulinium neurotoxin type A/BOTA.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Multi-pass membrane protein Cytoplasmic vesicle secretory vesicle acrosome Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids.
    Protein Attributes:
    Sequence length:
    683
    Sequence:
    50:
    MDDYRYRDNY | EGYAPNDGYY | RGNEQNPEED | AQSDVTEGHD | EEDEIYEGEY | 
    100:
    QGIPHPDDVK | SKQTKMAPSR | ADGLRGQADL | MAERMEDEEQ | LAHQYETIID | 
    150:
    ECGHGRFQWT | LFFVLVLALM | ADGVEVFVVS | FALPSAEKDM | CLSSSKKGML | 
    200:
    GLIVYLGMMA | GAFILGGLAD | KLGRKKVLSM | SLAINASFAS | LSSFVQGYGA | 
    250:
    FLFCRLISGI | GIGGSLPIVF | AYFSEFLSRE | KRGEHLSWLG | IFWMTGGIYA | 
    300:
    SAMAWSIIPH | YGWGFSMGTN | YHFHSWRVFV | IVCALPATVS | MVALKFMPES | 
    350:
    PRFLLEMGKH | DEAWMILKQV | HDTNMRAKGT | PEKVFTVSHI | KTPKQMDEFI | 
    400:
    EIQSSTGTWY | QRWLVRFMTI | FKQVWDNALY | CVMGPYRMNT | LILAVVWFTM | 
    450:
    ALSYYGLTVW | FPDMIRYFQD | EEYKSKMKVF | FGEHVHGATI | NFTMENQIHQ | 
    500:
    HGKLVNDKFI | KMYFKHVLFE | DTFFDKCYFE | DVTSTDTYFK | NCTIESTTFY | 
    550:
    NTDLYKHKFI | DCRFINSTFL | EQKEGCHMDF | EEDNDFLIYL | VSFLGSLSVL | 
    600:
    PGNIISALLM | DRIGRLKMIG | GSMLISAVCC | FFLFFGNSES | AMIGWQCLFC | 
    650:
    GTSIAAWNAL | DVITVELYPT | NQRATAFGIL | NGLCKLGAIL | GNTIFASFVG | 
    683:
    ITKVVPILLA | AASLVGGGLV | ALRLPETREQ | VLM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Synaptic vesicle protein 2B
    ELISA Kit for Rat Synaptic vesicle protein 2B
    ELISA Kit for Rat Synaptic vesicle protein 2B
    CLIA Kit for Rat Synaptic vesicle protein 2B
    CLIA Kit for Rat Synaptic vesicle protein 2B
    CLIA Kit for Rat Synaptic vesicle protein 2B
    Polyclonal Antibody for Rat Synaptic vesicle protein 2B
    Polyclonal Antibody for Rat Synaptic vesicle protein 2B
    Polyclonal Antibody for Rat Synaptic vesicle protein 2B
    Monoclonal Antibody for Rat Synaptic vesicle protein 2B
    Monoclonal Antibody for Rat Synaptic vesicle protein 2B
    Monoclonal Antibody for Rat Synaptic vesicle protein 2B
    Protein for Rat Synaptic vesicle protein 2B
    Protein for Rat Synaptic vesicle protein 2B
    Protein for Rat Synaptic vesicle protein 2B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
      tissue: Brain.
    2. 2.
      "Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42)."
      Heese K. , Nagai Y. , Sawada T.
      Biochem. Biophys. Res. Commun.289:924-928(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
    3. 3.
      "Synaptic vesicle protein SV2B, but not SV2A, is predominantly expressed and associated with microvesicles in rat pinealocytes."
      Hayashi M. , Yamamoto A. , Yatsushiro S. , Yamada H. , Futai M. , Yamaguchi A. , Moriyama Y.
      J. Neurochem.71:356-365(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    4. 4.
      "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
      Janz R. , Hofmann K. , Suedhof T.C.
      J. Neurosci.18:9269-9281(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
    5. 5.
      "SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family."
      Janz R. , Suedhof T.C.
      Neuroscience94:1279-1290(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin."
      Pyle R.A. , Schivell A.E. , Hidaka H. , Bajjalieh S.M.
      J. Biol. Chem.275:17195-17200(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CK1
    7. 7.
      "Brain synaptic junctional proteins at the acrosome of rat testicular germ cells."
      Redecker P. , Kreutz M.R. , Bockmann J. , Gundelfinger E.D. , Boeckers T.M.
      J. Histochem. Cytochem.51:809-819(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment."
      Iezzi M. , Theander S. , Janz R. , Loze C. , Wollheim C.B.
      J. Cell Sci.118:5647-5660(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "SV2A and SV2C contain a unique synaptotagmin-binding site."
      Schivell A.E. , Mochida S. , Kensel-Hammes P. , Custer K.L. , Bajjalieh S.M.
      Mol. Cell. Neurosci.29:56-64(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYT1
    10. 10.
      "SV2 is the protein receptor for botulinum neurotoxin A."
      Dong M. , Yeh F. , Tepp W.H. , Dean C. , Johnson E.A. , Janz R. , Chapman E.R.
      Science312:592-596(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A BOTA RECEPTOR
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