Gene name:
Swap70 (Kiaa0640) ;
Protein name:
Switch-associated protein 70 (SWAP-70) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.
Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Subcellular Location:
Cytoplasm
Cell membrane
Nucleus
Cell projection
lamellipodium
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Protein Attributes:
50:
MRGLKDELLK | AIWHAFTALD | LDRSGKVSKS | QLKVLSHNLC | TVLKVPHDPV |
100:
ALEEHFRDDD | EGPVSNQGYM | PYLNKFILEK | VQDNFDKIEF | NRMCWTLCVK |
150:
KNLTKSPLLI | TEDDAFKVWV | IFNFLSEDKY | PLIIVPEEIE | YLLKKLTEAM |
200:
GGGWQQEQFE | HYKINFDDNK | DGLSAWELIE | LIGNGQFSKG | MDRQTVSMAI |
250:
NEVFNELILD | VLKQGYMMKK | GHKRKNWTER | WFVLKPNIIS | YYVSEDLKDK |
300:
KGDILLDENC | CVESLPDKDG | KKCLFLIKCF | DKTFEISASD | KKKKQEWIQA |
350:
IYSTIHLLKL | GSPPPHKEAR | QRRKELRRKL | LAEQEELERQ | MKELQAANEN |
400:
KQQELESVRK | KLEEAASRAA | DEEKKRLQTQ | VELQTRFSTE | LEREKLIRQQ |
450:
MEEQVAQKSS | ELEQYLQRVR | ELEDMYLKLQ | EALEDERQAR | QDEETVRKLQ |
500:
ARLLEEESSK | RAELEKWHLE | QQQAIQTTEA | EKQELEQQRV | MKEQALQEAM |
550:
AQLEQLELER | KQALEQYEGV | KKKLEMATHM | TKSWKDKVAH | HEGLIRLIEP |
585:
GSKNPHLITN | WGPAAFTQAE | LEEREKSWKE | KKTTE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Bovine
ELISA Kit for Mouse SWAP-70
ELISA Kit for Mouse SWAP-70
ELISA Kit for Mouse SWAP-70
ELISA Kit for Mouse SWAP-70
CLIA Kit for Mouse SWAP-70
CLIA Kit for Mouse SWAP-70
CLIA Kit for Mouse SWAP-70
CLIA Kit for Mouse SWAP-70
Polyclonal Antibody for Mouse SWAP-70
Polyclonal Antibody for Mouse SWAP-70
Polyclonal Antibody for Mouse SWAP-70
Polyclonal Antibody for Mouse SWAP-70
Monoclonal Antibody for Mouse SWAP-70
Monoclonal Antibody for Mouse SWAP-70
Monoclonal Antibody for Mouse SWAP-70
Monoclonal Antibody for Mouse SWAP-70
Protein for Mouse SWAP-70
Protein for Mouse SWAP-70
Protein for Mouse SWAP-70
Protein for Mouse SWAP-70
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-24;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
C57BL/6 .
tissue :
Spleen .
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Embryonic tail .
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Egg .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Eye .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE