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Index > Protein center > Swap70(Gene name) > Mouse
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  • Swap70 (Gene name),
  • Switch-associated protein 70 (Protein name ),  SWP70_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Swap70(Kiaa0640);
    Protein name:
    Switch-associated protein 70(SWAP-70);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.
    Function:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Cell projection lamellipodium In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
    Protein Attributes:
    Sequence length:
    585
    Sequence:
    50:
    MRGLKDELLK | AIWHAFTALD | LDRSGKVSKS | QLKVLSHNLC | TVLKVPHDPV | 
    100:
    ALEEHFRDDD | EGPVSNQGYM | PYLNKFILEK | VQDNFDKIEF | NRMCWTLCVK | 
    150:
    KNLTKSPLLI | TEDDAFKVWV | IFNFLSEDKY | PLIIVPEEIE | YLLKKLTEAM | 
    200:
    GGGWQQEQFE | HYKINFDDNK | DGLSAWELIE | LIGNGQFSKG | MDRQTVSMAI | 
    250:
    NEVFNELILD | VLKQGYMMKK | GHKRKNWTER | WFVLKPNIIS | YYVSEDLKDK | 
    300:
    KGDILLDENC | CVESLPDKDG | KKCLFLIKCF | DKTFEISASD | KKKKQEWIQA | 
    350:
    IYSTIHLLKL | GSPPPHKEAR | QRRKELRRKL | LAEQEELERQ | MKELQAANEN | 
    400:
    KQQELESVRK | KLEEAASRAA | DEEKKRLQTQ | VELQTRFSTE | LEREKLIRQQ | 
    450:
    MEEQVAQKSS | ELEQYLQRVR | ELEDMYLKLQ | EALEDERQAR | QDEETVRKLQ | 
    500:
    ARLLEEESSK | RAELEKWHLE | QQQAIQTTEA | EKQELEQQRV | MKEQALQEAM | 
    550:
    AQLEQLELER | KQALEQYEGV | KKKLEMATHM | TKSWKDKVAH | HEGLIRLIEP | 
    585:
    GSKNPHLITN | WGPAAFTQAE | LEEREKSWKE | KKTTE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SWAP-70
    Cat.:
    E3416h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse SWAP-70
    Cat.:
    E3416c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse SWAP-70
    Cat.:
    E3416m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse SWAP-70
    Cat.:
    E3416b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SWAP-70
    Cat.:
    U3416h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SWAP-70
    Cat.:
    U3416b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse SWAP-70
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse SWAP-70
    Cat.:
    U3416m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse SWAP-70
    Polyclonal Antibody for Mouse SWAP-70
    Cat.:
    P3416Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SWAP-70
    Cat.:
    P3416Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse SWAP-70
    Monoclonal Antibody for Mouse SWAP-70
    Monoclonal Antibody for Mouse SWAP-70
    Monoclonal Antibody for Mouse SWAP-70
    Monoclonal Antibody for Mouse SWAP-70
    Protein for Mouse SWAP-70
    Protein for Mouse SWAP-70
    Protein for Mouse SWAP-70
    Protein for Mouse SWAP-70

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-24;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: C57BL/6.
      tissue: Spleen.
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
      DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Embryonic tail.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Egg.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Eye.
    5. 5.
      "Cellular, intracellular, and developmental expression patterns of murine SWAP-70."
      Borggrefe T. , Masat L. , Wabl M. , Riwar B. , Cattoretti G. , Jessberger R.
      Eur. J. Immunol.29:1812-1822(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
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