Tab2 ELISA Kit for Mouse(Mus musculus) | EIAab.comTab2 ELISA Kit for Mouse(Mus musculus)

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Tab2 (Gene name),

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Protein name ), TAB2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Tab2(Kiaa0733;Map3k7ip2);

Protein name:

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;

Alternative:

TAK1-binding protein 2(TAB-2);Mitogen-activated protein kinase kinase kinase 7-interacting protein 2;TGF-beta-activated kinase 1-binding protein 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1.

Function:

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.

Subcellular Location:

Nucleus Cytoplasm cytosol Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.

Protein Attributes:

Sequence length:

693

Sequence:

50:

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650:

693:

TIKAPKTQDA | EDEEGAQWNC | TACTFLNHPA | LIRCEQCEMP | RHF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q99K90

KEGG:

mmu:68652

Pfam:

PF02845

String:

Q99K90

UniGene:

Mm.193041

Uniprot:

Q99K90

FOR

ELISA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882r

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Packing:

96T

ELISA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882m

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Packing:

96T

CLIA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882r

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Packing:

96T

CLIA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Protein for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein."
Baek S.H. , Ohgi K.A. , Rose D.W. , Koo E.H. , Glass C.K. , Rosenfeld M.G.
Cell110:55-67(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;PHOSPHORYLATION;SUBCELLULAR LOCATION;FUNCTION
tissue: Brain.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
strain: FVB/N.
tissue: Mammary tumor.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-595
strain: C57BL/6J.
strain: NOD.
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.9:179-188(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-693
tissue: Embryonic tail.
5.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
6.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3."
Sato Y. , Yoshikawa A. , Yamashita M. , Yamagata A. , Fukai S.
EMBO J.28:3903-3909(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.18 ANGSTROMS) OF 665-693 IN COMPLEX WITH ZINC IONS AND 'LYS-63'-LINKED UBIQUITIN;FUNCTION;LINKAGE-SPECIFIC INTERACTION WITH UBIQUITIN;NZF DOMAIN;SUBUNIT;MUTAGENESIS OF THR-674; PHE-675; HIS-678; LEU-681; GLU-685 AND GLN-686

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