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Index > Protein center > Tep1(Gene name) > Rat
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  • Tep1 (Gene name),
  • Telomerase protein component 1 (Protein name ),  TEP1_RAT from NCBI database.
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  • Gene name:
    Tep1(Tlp1);
    Protein name:
    Telomerase protein component 1(rTLP1);
    Alternative:
    p230;Telomerase-associated protein 1(Telomerase protein 1);p80 telomerase homolog;p240;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.
    Function:
    Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
    Subcellular Location:
    Nucleus Chromosome telomere
    Protein Attributes:
    Sequence length:
    2629
    Sequence:
    50:
    MEKLCGYVPV | HPDILSLKNR | CLTMLSDIQP | LEKIHGQRSV | NPDILSLENR | 
    100:
    CLTLLPDLQP | MEKIHGQRSV | HPDILSSENR | CLTLLPDLQS | LEKLCGHMSS | 
    150:
    HPDVLSLENR | CLATLPTVKR | TVSSGPLLQC | LHRSHTAQAD | LRDPNFRNCL | 
    200:
    FPEPPTIEAP | CFLKELDLPT | GPRALKSMSA | TARVQEVALG | QRCVSEGKEL | 
    250:
    QEEKESAEVP | MPLYSLSLGG | EEEEVVGAPV | LKLTSGDSDS | HPETTDQILQ | 
    300:
    EKKMALLTLL | CSAMASSVNV | KDASDPTRAS | IHEVCSALAP | LEPEFILKAS | 
    350:
    LYARQQLNLR | DIANIVLAVA | ALLPACRPHV | RRYYSAIVHL | PSDWIQVAEF | 
    400:
    YQSLAEGDEK | KLVPLPACLR | AAMTDKFAQF | DEYQLAKYNP | RKHRSKTRSR | 
    450:
    QPPRPQRTKP | PFSESGKCFP | KSVWPLKNEQ | ISFEAAYNAV | SEKKRLPRFT | 
    500:
    LKKLVEQLHI | HEPAQHVQAL | LGYRYPSTLE | LFSRSHLPGP | WDSSRAGQRM | 
    550:
    KLQRPETWER | ELSLRGNRAS | VWEELIDNGK | LPFMAMLRNL | CNLLRTGISA | 
    600:
    HHHELVLQRL | QHEKSVIHSR | QFPFRFLNAH | DSLDRLEAQL | RSKASPFPSN | 
    650:
    TTLMKRIMIR | NSKKIKRPAN | PRYLCTLTQR | QLRAAMAIPV | MYEHLKREKL | 
    700:
    RLHKARQWTC | DLELLERYRQ | ALETAVNISV | KHNLPPLPGR | TLLVYLTDAN | 
    750:
    ANRLCPKSHL | QGPPLNYVLL | LIGMMMARAE | QTTVWLCGTG | TVKTPVLTAD | 
    800:
    EGILKTAIKL | QAQVQELEEN | DEWPLETFEK | YLLSLAVRRT | PIDRVILFGQ | 
    850:
    RMDTELLNVA | KQIIWQHVNS | KCLFVSVLLR | KMQYMSPNLN | PNDVTLSGCT | 
    900:
    DGILKFIAEH | GASRLLEHVG | QLDKIFKIPP | PPGKTKVSPL | RPLEENNPGP | 
    950:
    FVPISQHGWR | NIRLFISSTF | RDMHGERDLL | MRSVLPALQA | RAFPHRISLH | 
    1000:
    AIDLRWGITE | EETRRNRQLE | VCLGEVENSQ | LFVGILGSRY | GYTPPSYDLP | 
    1050:
    DHPHFHWTQR | YPSGRSVTEM | EVMQFLNRGQ | RSEPSDQALI | YFRDPGFLSS | 
    1100:
    VPDVWKPDFI | SESEEAAHRV | SELKRFLQEQ | KEVTCRRYSC | EWGGVAAGRP | 
    1150:
    YTGGLEEFGQ | LVLQDVWSVI | QKRYLQPGAQ | LEQPGSISEE | DLIQASFQQL | 
    1200:
    KSPPSPARPR | LLQDTVQQLM | LPHGRLSLVI | GQAGQGKTAF | LASLVSALKV | 
    1250:
    PDQPNVAPFV | FFHFSAARPD | QCLAFNLLRR | LCTHLHQKLG | EPSALPSTYR | 
    1300:
    GLVWELQQKL | LLKSAQWLQP | GQTLVLIIDG | ADKLVDHNGQ | LISDWIPKSL | 
    1350:
    PRRVHLVLSV | SSDSGLGETL | QQSQSAYVVA | LGSLVPSSRA | QLVREELALY | 
    1400:
    GKRLEESPFN | NQMRLLLAKQ | GSSLPLYLHL | VTDYLRLFTL | YEQVSERLRT | 
    1450:
    LPATLPLLLQ | HILSTLEQEH | GHNVLPQALT | ALEVTHSGLT | VDQLHAVLST | 
    1500:
    WLTLPKETKS | WEEAVAASHS | GNLYPLAPFA | YLVQSLRSLL | GEGPVERPGA | 
    1550:
    RLCLSDGPLR | TAVKRRYGKR | LGLEKTAHVL | IAAHLWKMCD | PDASGTFRSC | 
    1600:
    PPEALKDLPY | HLLQSGNHGL | LAKFLTNLHV | VAAYLEVGLV | PDLLEAYELY | 
    1650:
    ASSKPEVNQK | LPEADVAVFH | NFLKQQASLL | TQYPLLLLQQ | AASQPEESPV | 
    1700:
    CCQAPLLTQR | WHNQCILKWI | NKPQTLKGQQ | SLSLPISSSP | TAVAFSPNGQ | 
    1750:
    RAAVGTAGGT | IYLLNLRTWQ | EEKALVSGCD | GISSFAFLSD | TALFLTTFDG | 
    1800:
    LLELWDLQHG | CWVFQTKAHQ | YQITGCCLSP | DRRLLATVCL | GGYVKLWDTV | 
    1850:
    QGQLAFQYTH | PKSLNCITFH | PEGQVVATGN | WSGIVTFFQA | DGLKVTKELG | 
    1900:
    GPGPSVRTLA | FSAPGKVVAL | GRIDGTVELW | AWQEGTRLAA | FPAQCGGVST | 
    1950:
    VLFLHAGGRF | LTAGEDGKAQ | LWSGFLGRPR | GCLGSLYLSP | ALSVALNPDG | 
    2000:
    DQVAVGYRGD | GIKIYRISSG | PQEAQCQELN | VAVSALVWLS | PSVLVSGAED | 
    2050:
    GSLHGWMLRR | NSLQSLWLSS | VCQKPVLGLA | ASQEFLASAS | EDFTVRLWPR | 
    2100:
    QLLTQPHAVE | ELPCAAELRG | HEGPVCCCSF | SPDGRILATA | GRDRNLLCWD | 
    2150:
    VKVAQAPLLI | HTFSSCHRDW | ITGCTWTKDN | ILISCSSDGS | VGLWNPEAGQ | 
    2200:
    QLGQFPGHQS | AVSAVVAVEE | HIVSVSRDGT | LKVWDRQGVE | LTSIPAHSGP | 
    2250:
    ISQCAAALEP | RPAGQPGSEL | MVVTVGLDGA | TKLWHPLLVC | QIHTLQGHSG | 
    2300:
    PVTAAAASEA | SGLLLTSDNS | SVRLWQIPKE | ADDTCKPRSS | AVITAVAWAP | 
    2350:
    DGSLVVSGNE | AGELTLWQKA | QAVATARAPG | RVSDLIWCSA | NAFFVLSANE | 
    2400:
    NVSEWQVELR | KGSTCTNFRL | YLKRVLQEDL | GVLTGMALAP | DGQSLILMKE | 
    2450:
    DVELLQMKPG | STPSSICRRY | AVHSSILCTS | KDYGLFYLQQ | GNSGSLSILE | 
    2500:
    QEESGKFEKT | LDFNLNLNNP | NGSPVSITQA | EPESGSSLLC | ATSDGMLWNL | 
    2550:
    SECTPEGEWV | VDNIWQKKSR | NPKSRTPGTD | SSPGLFCMDS | WVEPTHLKAR | 
    2600:
    QCKKIHLGSV | TALHVLPGLL | VTASEDRDVK | LWERPSMQLL | GLFRCEGPVS | 
    2629:
    CLEPWMEPSS | PLQLAVGDAQ | GNLYFLSWE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat rTLP1
    Cat.:
    E0558h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat rTLP1
    Cat.:
    E0558r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat rTLP1
    Cat.:
    E0558m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat rTLP1
    Cat.:
    U0558h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat rTLP1
    Cat.:
    U0558m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat rTLP1
    Cat.:
    U0558r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat rTLP1
    Cat.:
    P0558Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat rTLP1
    Cat.:
    P0558Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat rTLP1
    Cat.:
    P0558Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat rTLP1
    Monoclonal Antibody for Rat rTLP1
    Monoclonal Antibody for Rat rTLP1
    Protein for Rat rTLP1
    Cat.:
    R0558h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat rTLP1
    Protein for Rat rTLP1

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    References
    1. 1.
      "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family."
      Nakayama J. , Saito M. , Nakamura H. , Matsuura A. , Ishikawa F.
      Cell88:875-884(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX
      strain: Fischer 344.
      tissue: Fibroblast.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE
    3. 3.
      "RNA location and modeling of a WD40 repeat domain within the vault."
      Kong L.B. , Siva A.C. , Kickhoefer V.A. , Rome L.H. , Stewart P.L.
      RNA6:890-900(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON CRYOMICROSCOPY (22 ANGSTROMS) OF VAULT COMPLEX AND TEP1 WD REPEATS MODELING
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