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Index > Protein center > Thra(Gene name) > Mouse
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  • Thra (Gene name),
  • Thyroid hormone receptor alpha (Protein name ),  THA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Thra(C-erba-alpha;Nr1a1);
    Protein name:
    Thyroid hormone receptor alpha;
    Alternative:
    c-erbA-1;Nuclear receptor subfamily 1 group A member 1;c-erbA-alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13 (By similarity). Interacts with C1D.
    Function:
    Nuclear hormone receptor. High affinity receptor for triiodothyronine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.
    Subcellular Location:
    Isoform Alpha-deltaE6 Cytoplasm Sequesters isoform Alpha-1 into this compartment.
    Protein Attributes:
    Sequence length:
    492
    Sequence:
    50:
    MEQKPSKVEC | GSDPEENSAR | SPDGKRKRKN | GQCPLKSSMS | GYIPSYLDKD | 
    100:
    EQCVVCGDKA | TGYHYRCITC | EGCKGFFRRT | IQKNLHPTYS | CKYDSCCVID | 
    150:
    KITRNQCQLC | RFKKCIAVGM | AMDLVLDDSK | RVAKRKLIEQ | NRERRRKEEM | 
    200:
    IRSLQQRPEP | TPEEWDLIHV | ATEAHRSTNA | QGSHWKQRRK | FLPDDIGQSP | 
    250:
    IVSMPDGDKV | DLEAFSEFTK | IITPAITRVV | DFAKKLPMFS | ELPCEDQIIL | 
    300:
    LKGCCMEIMS | LRAAVRYDPE | SDTLTLSGEM | AVKREQLKNG | GLGVVSDAIF | 
    350:
    ELGKSLSAFN | LDDTEVALLQ | AVLLMSTDRS | GLLCVDKIEK | SQEAYLLAFE | 
    400:
    HYVNHRKHNI | PHFWPKLLMK | EREVQSSILY | KGAAAEGRPG | GSLGVHPEGQ | 
    450:
    QLLGMHVVQG | PQVRQLEQQL | GEAGSLRGPV | LQHQSPKSPQ | QRLLELLHRS | 
    492:
    GILHSRAVCG | EDDSSEASSL | SSSSDTEDTE | VCEDQAGKAA | SP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Thyroid hormone receptor alpha
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    E1927r
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    ELISA Kit for Mouse Thyroid hormone receptor alpha
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    E1927h
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    ELISA Kit for Mouse Thyroid hormone receptor alpha
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    E1927p
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    ELISA Kit for Mouse Thyroid hormone receptor alpha
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    E1927c
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    96T
    ELISA Kit for Mouse Thyroid hormone receptor alpha
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    E1927m
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    96T
    CLIA Kit for Mouse Thyroid hormone receptor alpha
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    U1927h
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    96T
    CLIA Kit for Mouse Thyroid hormone receptor alpha
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    U1927c
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    96T
    CLIA Kit for Mouse Thyroid hormone receptor alpha
    Cat.:
    U1927r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Thyroid hormone receptor alpha
    Cat.:
    U1927m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Thyroid hormone receptor alpha
    Cat.:
    U1927p
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Thyroid hormone receptor alpha
    Polyclonal Antibody for Mouse Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Thyroid hormone receptor alpha
    Monoclonal Antibody for Mouse Thyroid hormone receptor alpha
    Monoclonal Antibody for Mouse Thyroid hormone receptor alpha
    Monoclonal Antibody for Mouse Thyroid hormone receptor alpha
    Monoclonal Antibody for Mouse Thyroid hormone receptor alpha
    Monoclonal Antibody for Mouse Thyroid hormone receptor alpha
    Protein for Mouse Thyroid hormone receptor alpha
    Protein for Mouse Thyroid hormone receptor alpha
    Protein for Mouse Thyroid hormone receptor alpha
    Protein for Mouse Thyroid hormone receptor alpha
    Protein for Mouse Thyroid hormone receptor alpha

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    References
    1. 1.
      "Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries."
      Prost E. , Koenig R.J. , Moore D.D. , Larsen P.R. , Whalen R.G.
      Nucleic Acids Res.16:6248-6248(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1);NUCLEOTIDE SEQUENCE [MRNA] OF 1-452 (ISOFORMS ALPHA-2 AND ALPHA-3)
      strain: C3H.
      tissue: Muscle.
    2. 2.
      "Nucleotide sequence of the murine thyroid hormone receptor (alpha-1) cDNA."
      Masuda M. , Yasuhara S. , Yamashita M. , Shibuya M. , Odaka T.
      Nucleic Acids Res.18:3055-3055(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1)
      strain: C3H.
      tissue: Testis.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1)
      strain: C57BL/6J.
      tissue: Olfactory bulb.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-2)
      strain: C57BL/6.
      tissue: Brain.
    7. 7.
      "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
      Zamir I. , Dawson J. , Lavinsky R.M. , Glass C.K. , Rosenfeld M.G. , Lazar M.A.
      Proc. Natl. Acad. Sci. U.S.A.94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1D
    8. 8.
      "Cloning and characterization of RAP250, a nuclear receptor coactivator."
      Caira F. , Antonson P. , Pelto-Huikko M. , Treuter E. , Gustafsson J.-A.
      J. Biol. Chem.275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    9. 9.
      "Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation."
      Casas F. , Busson M. , Grandemange S. , Seyer P. , Carazo A. , Pessemesse L. , Wrutniak-Cabello C. , Cabello G.
      Mol. Endocrinol.20:749-763(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS ALPHA-1 AND ALPHA-DELTAE6);POTENTIAL RNA EDITING OF ISOFORM ALPHA-DELTAE6;FUNCTION;TISSUE SPECIFICITY
    10. 10.
      "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
      Schmutz I. , Ripperger J.A. , Baeriswyl-Aebischer S. , Albrecht U.
      Genes Dev.24:345-357(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER2
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