TIGIT ELISA Kit for Human(Homo sapiens) | EIAab.comTIGIT ELISA Kit for Human(Homo sapiens)

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TIGIT (Gene name),

T cell immunoreceptor with Ig and ITIM domains (Protein name ), TIGIT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TIGIT(VSIG9;VSTM3);

Protein name:

T cell immunoreceptor with Ig and ITIM domains;

Alternative:

V-set and transmembrane domain-containing protein 3;V-set and immunoglobulin domain-containing protein 9;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds with high affinity to PVR and with lower affinity to PVRL2 and PVRL3.

Function:

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

244

Sequence:

50:

100:

150:

200:

244:

VQAEAAPAGL | CGEQRGEDCA | ELHDYFNVLS | YRSLGNCSFF | TETG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

SMR:

Q495A1

MIM:

612859

KEGG:

hsa:201633

UniGene:

Hs.421750

STRING:

9606.ENSP00000373167

String:

Q495A1

Uniprot:

Q495A1

FOR

ELISA Kit for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

E4062h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

E4062m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

U4062h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

U4062m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

P4062Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human T cell immunoreceptor with Ig and ITIM domains

Cat.:

P4062Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human T cell immunoreceptor with Ig and ITIM domains

Protein for Human T cell immunoreceptor with Ig and ITIM domains

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Spleen.
2.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-244 (ISOFORM 2)
tissue: Lymph node.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Yu X. , Harden K. , Gonzalez L.C. , Francesco M. , Chiang E. , Irving B. , Tom I. , Ivelja S. , Refino C.J. , Clark H. , Eaton D. , Grogan J.L.
Nat. Immunol.10:48-57(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PVR; PVRL2 AND PVRL3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

"Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering."
Stengel K.F. , Harden-Bowles K. , Yu X. , Rouge L. , Yin J. , Comps-Agrar L. , Wiesmann C. , Bazan J.F. , Eaton D.L. , Grogan J.L.
Proc. Natl. Acad. Sci. U.S.A.109:5399-5404(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 23-128 ALONE AND IN COMPLEX WITH PVR;DISULFIDE BOND;SUBUNIT;MUTAGENESIS OF ILE-42

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