LTA ELISA Kit for Human(Homo sapiens) | EIAab.comLTA ELISA Kit for Human(Homo sapiens)

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LTA (Gene name),

Lymphotoxin-alpha (Protein name ), TNFB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LTA(TNFB;TNFSF1);

Protein name:

Lymphotoxin-alpha(LT-alpha);

Alternative:

Tumor necrosis factor ligand superfamily member 1;TNF-beta;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.

Function:

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Subcellular Location:

Secreted Membrane The homotrimer is secreted. The heterotrimer is membrane-associated.

Protein Attributes:

Sequence length:

205

Sequence:

50:

100:

150:

200:

205:

GAFAL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00229

UniGene:

Hs.36

String:

P01374

SMR:

P01374

MIM:

153440

KEGG:

hsa:4049

STRING:

9606.ENSP00000372793

Uniprot:

P01374

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ELISA Kit for Human LT-alpha

Cat.:

E0134h

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96T

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ELISA Kit for Human LT-alpha

Cat.:

E0134m

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Packing:

96T

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ELISA Kit for Human LT-alpha

Cat.:

E0134p

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96T

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ELISA Kit for Human LT-alpha

Cat.:

E0134b

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96T

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ELISA Kit for Human LT-alpha

Cat.:

E0134r

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96T

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ELISA Kit for Human LT-alpha

Cat.:

E0134d

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Packing:

96T

ELISA Kit for Human LT-alpha

MSDS:

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CLIA Kit for Human LT-alpha

MSDS:

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CLIA Kit for Human LT-alpha

Cat.:

U0134d

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Packing:

96T

CLIA Kit for Human LT-alpha

Cat.:

U0134r

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Packing:

96T

CLIA Kit for Human LT-alpha

Cat.:

U0134b

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human LT-alpha

Cat.:

U0134p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human LT-alpha

Cat.:

U0134m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human LT-alpha

Cat.:

U0134h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human LT-alpha

Cat.:

P0134Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LT-alpha

Cat.:

P0134Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LT-alpha

Cat.:

P0134Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LT-alpha

Monoclonal Antibody for Human LT-alpha

Protein for Human LT-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome."
Nedospasov S.A. , Shakhov A.N. , Turetskaya R.L. , Mett V.A. , Azizov M.M. , Georgiev G.P. , Korobko V.G. , Dobrynin V.N. , Filippov S.A. , Bystrov N.S. , Boldyreva E.F. , Chuvpilo S.A. , Chumakov A.M. , Shingarova L.N. , Ovchinnikov Y.A.
Cold Spring Harb. Symp. Quant. Biol.51:611-624(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Structure and chromosomal localization of the human lymphotoxin gene."
Nedwin G.E. , Jarrett-Nedwin J. , Smith D.H. , Naylor S.L. , Sakaguchi A.Y. , Goeddel D.V. , Gray P.W.
J. Cell. Biochem.29:171-181(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma."
Kobayashi Y. , Miyamoto D. , Asada M. , Obinata M. , Osawa T.
J. Biochem.100:727-733(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity."
Gray P.W. , Aggarwal B.B. , Benton C.V. , Bringman T.S. , Henzel W.J. , Jarrett J.A. , Leung D.W. , Moffat B. , Ng P. , Svedersky L.P. , Palladino M.A. , Nedwin G.E.
Nature312:721-724(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788."
Matsuyama N. , Okawa N. , Tsukii Y. , Endo T. , Kaji A.
FEBS Lett.302:141-144(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
Iris F.J.M. , Bougueleret L. , Prieur S. , Caterina D. , Primas G. , Perrot V. , Jurka J. , Rodriguez-Tome P. , Claverie J.-M. , Dausset J. , Cohen D.
Nat. Genet.3:137-145(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
Neville M.J. , Campbell R.D.
J. Immunol.162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S. , Tamiya G. , Oka A. , Inoko H.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

SeattleSNPs variation discovery resource
Submitted (2001-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
11.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-13
tissue: Lymph.
13.

"Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation."
Voigt C.G. , Maurer-Fogy I. , Adolf G.R.
FEBS Lett.314:85-88(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT THR-41 AND ASN-96;VARIANT ASN-60
14.

"The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution."
Eck M.J. , Ultsch M. , Rinderknecht E. , de Vos A.M. , Sprang S.R.
J. Biol. Chem.267:2119-2122(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
15.

"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."
Banner D.W. , D'Arcy A. , Janes W. , Gentz R. , Schoenfeld H.-J. , Broger C. , Loetscher H. , Lesslauer W.
Cell73:431-445(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 61-205 OF COMPLEX WITH TNFR1
16.

"Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production."
Messer G. , Spengler U. , Jung M.C. , Honold G. , Bloemer K. , Pape G.R. , Riethmueller G. , Weiss E.H.
J. Exp. Med.173:209-219(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-60
17.

"Haplotypic polymorphisms of the TNFB gene."
Abraham L.J. , Du D.C. , Zahedi K. , Dawkins R.L. , Whitehead A.S.
Immunogenetics33:50-53(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-125
18.

"Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity."
Balding J. , Kane D. , Livingstone W. , Mynett-Johnson L. , Bresnihan B. , Smith O. , FitzGerald O.
Arthritis Rheum.48:1408-1413(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY
19.

"Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy."
Alcaies A. , Alter A. , Antoni G. , Orlova M. , Nguyen V.T. , Singh M. , Vanderborght P.R. , Katoch K. , Mira M.T. , Vu H.T. , Ngyuen T.H. , Nguyen N.B. , Moraes M. , Mehra N. , Schurr E. , Abel L.
Nat. Genet.39:517-522(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LPRS4

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