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Index > Protein center > TNFRSF21(Gene name) > Human
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  • TNFRSF21 (Gene name),
  • Tumor necrosis factor receptor superfamily member 21 (Protein name ),  TNR21_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFRSF21(UNQ437/PRO868;DR6);
    Protein name:
    Tumor necrosis factor receptor superfamily member 21;
    Alternative:
    Death receptor 6;
    CD:
    CD358;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with TRADD. Interacts with N-APP.
    Function:
    May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    655
    Sequence:
    50:
    MGTSPSSSTA | LASCSRIARR | ATATMIAGSL | LLLGFLSTTT | AQPEQKASNL | 
    100:
    IGTYRHVDRA | TGQVLTCDKC | PAGTYVSEHC | TNTSLRVCSS | CPVGTFTRHE | 
    150:
    NGIEKCHDCS | QPCPWPMIEK | LPCAALTDRE | CTCPPGMFQS | NATCAPHTVC | 
    200:
    PVGWGVRKKG | TETEDVRCKQ | CARGTFSDVP | SSVMKCKAYT | DCLSQNLVVI | 
    250:
    KPGTKETDNV | CGTLPSFSSS | TSPSPGTAIF | PRPEHMETHE | VPSSTYVPKG | 
    300:
    MNSTESNSSA | SVRPKVLSSI | QEGTVPDNTS | SARGKEDVNK | TLPNLQVVNH | 
    350:
    QQGPHHRHIL | KLLPSMEATG | GEKSSTPIKG | PKRGHPRQNL | HKHFDINEHL | 
    400:
    PWMIVLFLLL | VLVVIVVCSI | RKSSRTLKKG | PRQDPSAIVE | KAGLKKSMTP | 
    450:
    TQNREKWIYY | CNGHGIDILK | LVAAQVGSQW | KDIYQFLCNA | SEREVAAFSN | 
    500:
    GYTADHERAY | AALQHWTIRG | PEASLAQLIS | ALRQHRRNDV | VEKIRGLMED | 
    550:
    TTQLETDKLA | LPMSPSPLSP | SPIPSPNAKL | ENSALLTVEP | SPQDKNKGFF | 
    600:
    VDESEPLLRC | DSTSSGSSAL | SRNGSFITKE | KKDTVLRQVR | LDPCDLQPIF | 
    650:
    DDMLHFLNPE | ELRVIEEIPQ | AEDKLDRLFE | IIGVKSQEAS | QTLLDSVYSH | 
    655:
    LPDLL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
    Protein for Human Tumor necrosis factor receptor superfamily member 21
    Protein for Human Tumor necrosis factor receptor superfamily member 21
    Protein for Human Tumor necrosis factor receptor superfamily member 21

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor."
      Pan G. , Bauer J.H. , Haridas V. , Wang S. , Liu D. , Yu G. , Vincenz C. , Aggarwal B.B. , Ni J. , Dixit V.M.
      FEBS Lett.431:351-356(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH TRADD
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Colon.
      tissue: Eye.
    7. 7.
      "Functional analysis of the posttranslational modifications of the death receptor 6."
      Klima M. , Zajedova J. , Doubravska L. , Andera L.
      Biochim. Biophys. Acta1793:1579-1587(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION AT ASN-82; ASN-141; ASN-252; ASN-257; ASN-278 AND ASN-289;MUTAGENESIS OF ASN-82; ASN-141; ASN-252; ASN-257; ASN-278 AND ASN-289;INDUCTION BY TNF;PALMITOYLATION AT CYS-368
    8. 8.
      "Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination."
      Mi S. , Lee X. , Hu Y. , Ji B. , Shao Z. , Yang W. , Huang G. , Walus L. , Rhodes K. , Gong B.J. , Miller R.H. , Pepinsky R.B.
      Nat. Med.17:816-821(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    9. 9.
      "Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein."
      Zeng L. , Li T. , Xu D.C. , Liu J. , Mao G. , Cui M.Z. , Fu X. , Xu X.
      J. Biol. Chem.287:29125-29133(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death."
      Hu Y. , Lee X. , Shao Z. , Apicco D. , Huang G. , Gong B.J. , Pepinsky R.B. , Mi S.
      Cell Death Dis.4:E579-E579(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY;INTERACTION WITH NGFR
    11. 11.
      "Solution structure of the carboxyl-terminal CARD-like domain in human TNFR-related death receptor-6."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-12) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 562-655
    12. 12.
      "The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP)."
      Kuester M. , Kemmerzehl S. , Dahms S.O. , Roeser D. , Than M.E.
      J. Mol. Biol.409:189-201(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 42-218;DISULFIDE BOND
    13. 13.
      "S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS."
      Ru H. , Zhao L. , Ding W. , Jiao L. , Shaw N. , Liang W. , Zhang L. , Hung L.W. , Matsugaki N. , Wakatsuki S. , Liu Z.J.
      Acta Crystallogr. D68:521-530(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 42-349;DISULFIDE BOND;GLYCOSYLATION
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