Gene name:
TNFRSF21 (UNQ437/PRO868;DR6) ;
Protein name:
Tumor necrosis factor receptor superfamily member 21 ;
Alternative:
Death receptor 6 ;
CD:
CD358 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with TRADD. Interacts with N-APP.
Function:
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGTSPSSSTA | LASCSRIARR | ATATMIAGSL | LLLGFLSTTT | AQPEQKASNL |
100:
IGTYRHVDRA | TGQVLTCDKC | PAGTYVSEHC | TNTSLRVCSS | CPVGTFTRHE |
150:
NGIEKCHDCS | QPCPWPMIEK | LPCAALTDRE | CTCPPGMFQS | NATCAPHTVC |
200:
PVGWGVRKKG | TETEDVRCKQ | CARGTFSDVP | SSVMKCKAYT | DCLSQNLVVI |
250:
KPGTKETDNV | CGTLPSFSSS | TSPSPGTAIF | PRPEHMETHE | VPSSTYVPKG |
300:
MNSTESNSSA | SVRPKVLSSI | QEGTVPDNTS | SARGKEDVNK | TLPNLQVVNH |
350:
QQGPHHRHIL | KLLPSMEATG | GEKSSTPIKG | PKRGHPRQNL | HKHFDINEHL |
400:
PWMIVLFLLL | VLVVIVVCSI | RKSSRTLKKG | PRQDPSAIVE | KAGLKKSMTP |
450:
TQNREKWIYY | CNGHGIDILK | LVAAQVGSQW | KDIYQFLCNA | SEREVAAFSN |
500:
GYTADHERAY | AALQHWTIRG | PEASLAQLIS | ALRQHRRNDV | VEKIRGLMED |
550:
TTQLETDKLA | LPMSPSPLSP | SPIPSPNAKL | ENSALLTVEP | SPQDKNKGFF |
600:
VDESEPLLRC | DSTSSGSSAL | SRNGSFITKE | KKDTVLRQVR | LDPCDLQPIF |
650:
DDMLHFLNPE | ELRVIEEIPQ | AEDKLDRLFE | IIGVKSQEAS | QTLLDSVYSH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 21
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 21
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 21
Protein for Human Tumor necrosis factor receptor superfamily member 21
Protein for Human Tumor necrosis factor receptor superfamily member 21
Protein for Human Tumor necrosis factor receptor superfamily member 21
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Placenta .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
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tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;GLYCOSYLATION AT ASN-82; ASN-141; ASN-252; ASN-257; ASN-278 AND ASN-289;MUTAGENESIS OF ASN-82; ASN-141; ASN-252; ASN-257; ASN-278 AND ASN-289;INDUCTION BY TNF;PALMITOYLATION AT CYS-368
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
Europe PMC ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 42-349;DISULFIDE BOND;GLYCOSYLATION