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Index > Protein center > Tnfrsf21(Gene name) > Mouse
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  • Tnfrsf21 (Gene name),
  • Tumor necrosis factor receptor superfamily member 21 (Protein name ),  TNR21_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Tnfrsf21(Dr6);
    Protein name:
    Tumor necrosis factor receptor superfamily member 21;
    Alternative:
    Death receptor 6;
    CD:
    CD358;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Associates with TRADD (By similarity). Interacts with N-APP.
    Function:
    May activate NF-kappa-B and promote apoptosis (By similarity). May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    655
    Sequence:
    50:
    MGTRASSITA | LASCSRTAGQ | VGATMVAGSL | LLLGFLSTIT | AQPEQKTLSL | 
    100:
    PGTYRHVDRT | TGQVLTCDKC | PAGTYVSEHC | TNMSLRVCSS | CPAGTFTRHE | 
    150:
    NGIERCHDCS | QPCPWPMIER | LPCAALTDRE | CICPPGMYQS | NGTCAPHTVC | 
    200:
    PVGWGVRKKG | TENEDVRCKQ | CARGTFSDVP | SSVMKCKAHT | DCLGQNLEVV | 
    250:
    KPGTKETDNV | CGMRLFFSST | NPPSSGTVTF | SHPEHMESHD | VPSSTYEPQG | 
    300:
    MNSTDSNSTA | SVRTKVPSGI | EEGTVPDNTS | STSGKEGTNR | TLPNPPQVTH | 
    350:
    QQAPHHRHIL | KLLPSSMEAT | GEKSSTAIKA | PKRGHPRQNA | HKHFDINEHL | 
    400:
    PWMIVLFLLL | VLVLIVVCSI | RKSSRTLKKG | PRQDPSAIVE | KAGLKKSLTP | 
    450:
    TQNREKWIYY | RNGHGIDILK | LVAAQVGSQW | KDIYQFLCNA | SEREVAAFSN | 
    500:
    GYTADHERAY | AALQHWTIRG | PEASLAQLIS | ALRQHRRNDV | VEKIRGLMED | 
    550:
    TTQLETDKLA | LPMSPSPLSP | SPMPSPNVKL | ENSTLLTVEP | SPLDKNKCFF | 
    600:
    VDESEPLLRC | DSTSSGSSAL | SRNGSFITKE | KKDTVLRQVR | LDPCDLQPIF | 
    650:
    DDMLHILNPE | ELRVIEEIPQ | AEDKLDRLFE | IIGVKSQEAS | QTLLDSVYSH | 
    655:
    LPDLL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 21
    Protein for Mouse Tumor necrosis factor receptor superfamily member 21
    Protein for Mouse Tumor necrosis factor receptor superfamily member 21
    Protein for Mouse Tumor necrosis factor receptor superfamily member 21

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mouse DR6: mouse homolog of human TNFR-related death receptor-6 (DR6)."
      Isogai D. , Ichino M. , Yoshinari M. , Yamaura A. , Kurokawa F. , Minami M.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
      tissue: Kidney.
    2. 2.
      "Murine DR6: murine TNFR-related death receptor-6."
      Kim V. , Machleidt T. , Shi W.-X. , Wang X. , Cai Z.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Kidney.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Brain cortex.
      tissue: Medulla oblongata.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    5. 5.
      "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice."
      Liu J. , Na S. , Glasebrook A. , Fox N. , Solenberg P.J. , Zhang Q. , Song H.Y. , Yang D.D.
      Immunity15:23-34(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    6. 6.
      "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice."
      Zhao H. , Yan M. , Wang H. , Erickson S. , Grewal I.S. , Dixit V.M.
      J. Exp. Med.194:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    7. 7.
      "Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6."
      Schmidt C.S. , Liu J. , Zhang T. , Song H.Y. , Sandusky G. , Mintze K. , Benschop R.J. , Glasebrook A. , Yang D.D. , Na S.
      J. Exp. Med.197:51-62(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases."
      Nikolaev A. , McLaughlin T. , O'Leary D.D.M. , Tessier-Lavigne M.
      Nature457:981-989(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH APP
    9. 9.
      "Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination."
      Mi S. , Lee X. , Hu Y. , Ji B. , Shao Z. , Yang W. , Huang G. , Walus L. , Rhodes K. , Gong B.J. , Miller R.H. , Pepinsky R.B.
      Nat. Med.17:816-821(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    10. 10.
      "A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death."
      Hu Y. , Lee X. , Shao Z. , Apicco D. , Huang G. , Gong B.J. , Pepinsky R.B. , Mi S.
      Cell Death Dis.4:E579-E579(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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