Tnfrsf21 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comTnfrsf21 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Tnfrsf21(Gene name) > Rat

Tnfrsf21 (Gene name),

Tumor necrosis factor receptor superfamily member 21 (Protein name ), TNR21_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Tnfrsf21(Dr6);

Protein name:

Tumor necrosis factor receptor superfamily member 21;

Alternative:

Death receptor 6;

CD:

CD358;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Associates with TRADD. Interacts with NGFR. Interacts with N-APP.

Function:

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Plays a role in signaling cascades triggered by stimulation of T cell receptors, in the adaptive immune response and in the regulation of T cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T cell stimulation (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

655

Sequence:

50:

100:

150:

200:

250:

300: