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Index > Protein center > LTBR(Gene name) > Human
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  • LTBR (Gene name),
  • Tumor necrosis factor receptor superfamily member 3 (Protein name ),  TNR3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LTBR(D12S370;TNFCR;TNFR3;TNFRSF3);
    Protein name:
    Tumor necrosis factor receptor superfamily member 3;
    Alternative:
    Tumor necrosis factor C receptor;Lymphotoxin-beta receptor;Tumor necrosis factor receptor type III(TNF-RIII;TNFR-III);Tumor necrosis factor receptor 2-related protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.
    Function:
    Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    435
    Sequence:
    50:
    MLLPWATSAP | GLAWGPLVLG | LFGLLAASQP | QAVPPYASEN | QTCRDQEKEY | 
    100:
    YEPQHRICCS | RCPPGTYVSA | KCSRIRDTVC | ATCAENSYNE | HWNYLTICQL | 
    150:
    CRPCDPVMGL | EEIAPCTSKR | KTQCRCQPGM | FCAAWALECT | HCELLSDCPP | 
    200:
    GTEAELKDEV | GKGNNHCVPC | KAGHFQNTSS | PSARCQPHTR | CENQGLVEAA | 
    250:
    PGTAQSDTTC | KNPLEPLPPE | MSGTMLMLAV | LLPLAFFLLL | ATVFSCIWKS | 
    300:
    HPSLCRKLGS | LLKRRPQGEG | PNPVAGSWEP | PKAHPYFPDL | VQPLLPISGD | 
    350:
    VSPVSTGLPA | APVLEAGVPQ | QQSPLDLTRE | PQLEPGEQSQ | VAHGTNGIHV | 
    400:
    TGGSMTITGN | IYIYNGPVLG | GPPGPGDLPA | TPEPPYPIPE | EGDPGPPGLS | 
    435:
    TPHQEDGKAW | HLAETEHCGA | TPSNRGPRNQ | FITHD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 3
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 3
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 3
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 3
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 3
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 3
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 3
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 3
    Protein for Human Tumor necrosis factor receptor superfamily member 3
    Protein for Human Tumor necrosis factor receptor superfamily member 3

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid."
      Baens M. , Chaffanet M. , Cassiman J.-J. , van den Berghe H. , Marynen P.
      Genomics16:214-218(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Adrenal gland.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells."
      Wu M.-Y. , Wang P.-Y. , Han S.-H. , Hsieh S.-L.
      J. Biol. Chem.274:11868-11873(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells."
      Rooney I.A. , Butrovich K.D. , Glass A.A. , Borboroglu S. , Benedict C.A. , Whitbeck J.C. , Cohen G.H. , Eisenberg R.J. , Ware C.F.
      J. Biol. Chem.275:14307-14315(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
      Nakano H. , Oshima H. , Chung W. , Williams-Abbott L. , Ware C.F. , Yagita H. , Okumura K.
      J. Biol. Chem.271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF3
    10. 10.
      "Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor."
      Matsumoto M. , Hsieh T.-Y. , Zhu N. , VanArsdale T. , Hwang S.B. , Jeng K.-S. , Gorbalenya A.E. , Lo S.-Y. , Ou J.-H. , Ware C.F. , Lai M.M.C.
      J. Virol.71:1301-1309(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV CORE PROTEIN
    11. 11.
      "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues."
      Krajewska M. , Krajewski S. , Zapata J.M. , VanArsdale T. , Gascoyne R.D. , Berern K. , McFadden D. , Shabaik A. , Hugh J. , Reynolds A. , Clevenger C.V. , Reed J.C.
      Am. J. Pathol.152:1549-1561(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF4
    12. 12.
      "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."
      Mizushima S. , Fujita M. , Ishida T. , Azuma S. , Kato K. , Hirai M. , Otsuka M. , Yamamoto T. , Inoue J.
      Gene207:135-140(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF5
    13. 13.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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