E3 ubiquitin-protein ligase Topors (Protein name
), TOPRS_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
TOPORS(LUN;TP53BPL);
Protein name:
E3 ubiquitin-protein ligase Topors;
Alternative:
Topoisomerase I-binding RING finger protein;SUMO1-protein E3 ligase Topors;Tumor suppressor p53-binding protein 3(p53-binding protein 3;p53BP3);Topoisomerase I-binding arginine/serine-rich protein;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PARK7/DJ-1 (By similarity). Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinate and sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage.
Function:
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Subcellular Location:
Nucleus
Nucleus
PML body
Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH TOP1;SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PUTATIVE DNA-BINDING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-154; LYS-517 AND ASP-749
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-1045 (ISOFORM 1);INTERACTION WITH TP53;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: INTERACTION WITH SUMO1 AND UBE2I;SUBCELLULAR LOCATION;SUMOYLATION;MUTAGENESIS OF LYS-76; LYS-301; LYS-485; LYS-560 AND LYS-921
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Cited for: TISSUE SPECIFICITY;REDUCED EXPRESSION IN COLON CANCERS
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Cited for: PHOSPHORYLATION AT SER-98; SER-499; SER-585 AND SER-866;MUTAGENESIS OF SER-98;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: FUNCTION;INTERACTION WITH NKX3-1;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;INTERACTION WITH PLK1;PHOSPHORYLATION AT SER-718 BY PLK1;MUTAGENESIS OF SER-718;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-864 AND SER-866;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;INTERACTION WITH IKBKE;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-864 AND SER-866;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
