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Index > Protein center > Topors(Gene name) > Mouse
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  • Topors (Gene name),
  • E3 ubiquitin-protein ligase Topors (Protein name ),  TOPRS_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Topors;
    Protein name:
    E3 ubiquitin-protein ligase Topors;
    Alternative:
    Topoisomerase I-binding RING finger protein;SUMO1-protein E3 ligase Topors;Tumor suppressor p53-binding protein 3(p53-binding protein 3;p53BP3);Topoisomerase I-binding arginine/serine-rich protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TOP1. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage (By similarity). Interacts with p53/TP53. Interacts with PARK7/DJ-1.
    Function:
    Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.
    Subcellular Location:
    Nucleus Nucleus PML body Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
    Protein Attributes:
    Sequence length:
    1033
    Sequence:
    50:
    MGSQPPPPGS | PLSREEGEAP | PLVPAEEGRR | RSRRVRLRGS | CRHRPSLLSR | 
    100:
    RELASNGPAV | PATASSEIMA | SAAKEFKMDN | FSPKAGTSKL | QQTVPADASP | 
    150:
    DSKCPICLDR | FDNVSYLDRC | LHKFCFRCVQ | EWSKNKAECP | LCKQPFDSIF | 
    200:
    HSVRAEDDFK | EYVLRPSYNG | SFTNPEVRRF | RYRTTMTRER | SASLYSPSST | 
    250:
    VSRRTTTPPD | SGVLFEGLGI | STRPRDVDIP | QFMRQMALRG | PTTTDERSLR | 
    300:
    KIQEQDIINF | RRTLYRAGVR | VRSIEDGGRY | RDISAEFFRR | NPACLHRLVP | 
    350:
    WLKRELTVLF | GAHGSLVNIV | QHIIMSNVTR | YDLESQAFVS | DLRPFLLNRT | 
    400:
    EHFIHEFISF | ARSPFNMAAF | DQHANYDCPP | SSEEGSRSDS | SVITISPDEA | 
    450:
    ETQELDMNAS | TVRQAPWDDE | TPGPSYSSSE | QVHVGVSSLL | NSSDSSDEEL | 
    500:
    VSGGTTSQIQ | GVQTNDDVNN | DSDSSSDNCV | IVGFVKPLAE | RTPELVELSS | 
    550:
    DSEELGPYEK | VETVKTQEQE | QSYSSGDSDV | SRASSPRSVL | GKDEQMSKSH | 
    600:
    CDSDTRISSK | KEEKRSTSLP | APRDSSSTRG | DRVCSPYNHR | HRKGGRSRSS | 
    650:
    DSRSQSRSGH | DPRNHRKHGK | KRLRNKRSRS | RESSSRPRAR | KDKKRSRTRD | 
    700:
    SSWSRRSQTL | SLSSGSTSRS | RSRSSDHGKR | RSRSRNRDRY | YLRNNYGSKY | 
    750:
    KWEYTYYSRN | KDRDGYESSY | RRRTLSRAHY | SRQSSSPEFR | IQSFSERTNA | 
    800:
    RKKNHSERKY | YYYERRRSRS | VSSNRSRTTS | AGPDRVRNEK | PGGKRKYKTR | 
    850:
    HLEGTSEEAQ | PAREFTSKGK | DSHYQKSKLD | GSYKNESDSF | SDSRSSDRET | 
    900:
    KHKRRRRRTR | SLSVEIVYEG | KATDTSKHHK | KKKKKHKKKH | KKHHGDNTSR | 
    950:
    SPVVITIDSD | SDGESEVKAG | IECSNGSLPQ | PIQDGAFETK | DVVTIEDELG | 
    1000:
    VLDKDCDVTA | LADDLSTSQT | VENCDSPAVP | VEQTLDVREE | STFASDLESQ | 
    1033:
    SSNVSIQAEP | SRPVPSPRTS | LSSVSPGRDC | DVS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase Topors
    ELISA Kit for Mouse E3 ubiquitin-protein ligase Topors
    CLIA Kit for Mouse E3 ubiquitin-protein ligase Topors
    CLIA Kit for Mouse E3 ubiquitin-protein ligase Topors
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
    Protein for Mouse E3 ubiquitin-protein ligase Topors
    Protein for Mouse E3 ubiquitin-protein ligase Topors

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3."
      Shinbo Y. , Taira T. , Niki T. , Iguchi-Ariga S.M.M. , Ariga H.
      Int. J. Oncol.26:641-648(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PARK7 AND TP53;SUBCELLULAR LOCATION
      strain: C57BL/6.
    2. 2.
      "Topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage."
      Lin L. , Ozaki T. , Takada Y. , Kageyama H. , Nakamura Y. , Hata A. , Zhang J.H. , Simonds W.F. , Nakagawara A. , Koseki H.
      Oncogene24:3385-3396(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH TP53;SUBCELLULAR LOCATION;INDUCTION
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary gland.
      tissue: Mammary tumor.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-824
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
      tissue: Lung.
      tissue: Retina.
      tissue: Thymus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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