Protein name:
E3 ubiquitin-protein ligase Topors ;
Alternative:
Topoisomerase I-binding RING finger protein ;SUMO1-protein E3 ligase Topors ;Tumor suppressor p53-binding protein 3 (p53-binding protein 3;p53BP3) ;Topoisomerase I-binding arginine/serine-rich protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with TOP1. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage (By similarity). Interacts with p53/TP53. Interacts with PARK7/DJ-1.
Function:
Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.
Subcellular Location:
Nucleus
Nucleus
PML body
Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Protein Attributes:
50:
MGSQPPPPGS | PLSREEGEAP | PLVPAEEGRR | RSRRVRLRGS | CRHRPSLLSR |
100:
RELASNGPAV | PATASSEIMA | SAAKEFKMDN | FSPKAGTSKL | QQTVPADASP |
150:
DSKCPICLDR | FDNVSYLDRC | LHKFCFRCVQ | EWSKNKAECP | LCKQPFDSIF |
200:
HSVRAEDDFK | EYVLRPSYNG | SFTNPEVRRF | RYRTTMTRER | SASLYSPSST |
250:
VSRRTTTPPD | SGVLFEGLGI | STRPRDVDIP | QFMRQMALRG | PTTTDERSLR |
300:
KIQEQDIINF | RRTLYRAGVR | VRSIEDGGRY | RDISAEFFRR | NPACLHRLVP |
350:
WLKRELTVLF | GAHGSLVNIV | QHIIMSNVTR | YDLESQAFVS | DLRPFLLNRT |
400:
EHFIHEFISF | ARSPFNMAAF | DQHANYDCPP | SSEEGSRSDS | SVITISPDEA |
450:
ETQELDMNAS | TVRQAPWDDE | TPGPSYSSSE | QVHVGVSSLL | NSSDSSDEEL |
500:
VSGGTTSQIQ | GVQTNDDVNN | DSDSSSDNCV | IVGFVKPLAE | RTPELVELSS |
550:
DSEELGPYEK | VETVKTQEQE | QSYSSGDSDV | SRASSPRSVL | GKDEQMSKSH |
600:
CDSDTRISSK | KEEKRSTSLP | APRDSSSTRG | DRVCSPYNHR | HRKGGRSRSS |
650:
DSRSQSRSGH | DPRNHRKHGK | KRLRNKRSRS | RESSSRPRAR | KDKKRSRTRD |
700:
SSWSRRSQTL | SLSSGSTSRS | RSRSSDHGKR | RSRSRNRDRY | YLRNNYGSKY |
750:
KWEYTYYSRN | KDRDGYESSY | RRRTLSRAHY | SRQSSSPEFR | IQSFSERTNA |
800:
RKKNHSERKY | YYYERRRSRS | VSSNRSRTTS | AGPDRVRNEK | PGGKRKYKTR |
850:
HLEGTSEEAQ | PAREFTSKGK | DSHYQKSKLD | GSYKNESDSF | SDSRSSDRET |
900:
KHKRRRRRTR | SLSVEIVYEG | KATDTSKHHK | KKKKKHKKKH | KKHHGDNTSR |
950:
SPVVITIDSD | SDGESEVKAG | IECSNGSLPQ | PIQDGAFETK | DVVTIEDELG |
1000:
VLDKDCDVTA | LADDLSTSQT | VENCDSPAVP | VEQTLDVREE | STFASDLESQ |
1033:
SSNVSIQAEP | SRPVPSPRTS | LSSVSPGRDC | DVS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse E3 ubiquitin-protein ligase Topors
ELISA Kit for Mouse E3 ubiquitin-protein ligase Topors
CLIA Kit for Mouse E3 ubiquitin-protein ligase Topors
CLIA Kit for Mouse E3 ubiquitin-protein ligase Topors
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Topors
Protein for Mouse E3 ubiquitin-protein ligase Topors
Protein for Mouse E3 ubiquitin-protein ligase Topors
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PARK7 AND TP53;SUBCELLULAR LOCATION
strain :
C57BL/6 .
2.
"Topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage."
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Oncogene24:3385-3396(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH TP53;SUBCELLULAR LOCATION;INDUCTION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Mammary gland .
tissue :
Mammary tumor .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-824
strain :
C57BL/6J .
tissue :
Corpora quadrigemina .
tissue :
Lung .
tissue :
Retina .
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .