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Index > Protein center > TNFAIP8L2(Gene name) > Human
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  • TNFAIP8L2 (Gene name),
  • Tumor necrosis factor alpha-induced protein 8-like protein 2 (Protein name ),  TP8L2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFAIP8L2;
    Protein name:
    Tumor necrosis factor alpha-induced protein 8-like protein 2(TIPE2;TNF alpha-induced protein 8-like protein 2;TNFAIP8-like protein 2);
    Alternative:
    Inflammation factor protein 20;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.
    Function:
    Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    184
    Sequence:
    50:
    MESFSSKSLA | LQAEKKLLSK | MAGRSVAHLF | IDETSSEVLD | ELYRVSKEYT | 
    100:
    HSRPQAQRVI | KDLIKVAIKV | AVLHRNGSFG | PSELALATRF | RQKLRQGAMT | 
    150:
    ALSFGEVDFT | FEAAVLAGLL | TECRDVLLEL | VEHHLTPKSH | GRIRHVFDHF | 
    184:
    SDPGLLTALY | GPDFTQHLGK | ICDGLRKLLD | EGKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human TIPE2
    ELISA Kit for Human TIPE2
    ELISA Kit for Human TIPE2
    ELISA Kit for Human TIPE2
    ELISA Kit for Human TIPE2
    CLIA Kit for Human TIPE2
    CLIA Kit for Human TIPE2
    CLIA Kit for Human TIPE2
    CLIA Kit for Human TIPE2
    CLIA Kit for Human TIPE2
    Polyclonal Antibody for Human TIPE2
    Polyclonal Antibody for Human TIPE2
    Polyclonal Antibody for Human TIPE2
    Polyclonal Antibody for Human TIPE2
    Polyclonal Antibody for Human TIPE2
    Monoclonal Antibody for Human TIPE2
    Monoclonal Antibody for Human TIPE2
    Monoclonal Antibody for Human TIPE2
    Monoclonal Antibody for Human TIPE2
    Monoclonal Antibody for Human TIPE2
    Protein for Human TIPE2
    Protein for Human TIPE2
    Protein for Human TIPE2
    Protein for Human TIPE2
    Protein for Human TIPE2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis."
      Sun H. , Gong S. , Carmody R.J. , Hilliard A. , Li L. , Sun J. , Kong L. , Xu L. , Hilliard B. , Hu S. , Shen H. , Yang X. , Chen Y.H.
      Cell133:415-426(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Xu X. , Yang Y. , Gao G. , Xiao H. , Chen Z. , Han Z.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Small intestine.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lymph node.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    8. 8.
      "Crystal structure of TIPE2 provides insights into immune homeostasis."
      Zhang X. , Wang J. , Fan C. , Li H. , Sun H. , Gong S. , Chen Y.H. , Shi Y.
      Nat. Struct. Mol. Biol.16:89-90(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS);LACK OF INTERACTION WITH CASP8
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