Tnfrsf11b ELISA Kit for Mouse(Mus musculus) | EIAab.comTnfrsf11b ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Tnfrsf11b(Gene name) > Mouse

Tnfrsf11b (Gene name),

Tumor necrosis factor receptor superfamily member 11B (Protein name ), TR11B_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tnfrsf11b(Ocif;Opg);

Protein name:

Tumor necrosis factor receptor superfamily member 11B;

Alternative:

Osteoprotegerin;Osteoclastogenesis inhibitory factor;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

401

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

401:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.15383

KEGG:

mmu:18383

SMR:

O08712

Pfam:

PF00531

String:

O08712

Uniprot:

O08712

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ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

E0108h

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96T

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ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

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E0108r

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96T

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ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

E0108m

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ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

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E0108b

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96T

CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

U0108r

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96T

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CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

U0108b

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MSDS:

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96T

CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

U0108m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

U0108h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

P0108Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

P0108Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B

Cat.:

P0108Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B

Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B

Protein for Mouse Tumor necrosis factor receptor superfamily member 11B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.1%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.9%

Intra-Assay CV: ≤2.3

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of TR11B into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	92-98
Plasma	98	95-102

Inter-Assay CV: ≤7.5

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TR11B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-100%	93-99%	95-102%	93-98%
EDTA plasma(n=5)	90-96%	95-102%	101-105%	94-103%
heparin plasma(n=5)	94-99%	96-104%	95-100%	92-104%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density."
Simonet W.S. , Lacey D.L. , Dunstan C.R. , Kelley M. , Chang M.-S. , Luethy R. , Nguyen H.Q. , Wooden S. , Bennett L. , Boone T. , Shimamoto G. , Derose M. , Elliott R. , Colombero A. , Tan H.-L. , Trail G. , Sullivan J. , Davy E. , more...
Cell89:309-319(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Kidney.
2.

"Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis."
Mizuno A. , Murakami A. , Nakagawa N. , Yasuda H. , Tsuda E. , Morinaga T. , Higashio K.
Gene215:339-343(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANTS PRO-138; ARG-161; ASP-165; ALA-288 AND ARG-296
strain: 129/Ola.
strain: NIH Swiss.
tissue: Fibroblast.
3.

"Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis."
Min H. , Morony S. , Sarosi I. , Dunstan C.R. , Capparelli C. , Scully S. , Van G. , Kaufman S. , Kostenuik P.J. , Lacey D.L. , Boyle W.J. , Simonet W.S.
J. Exp. Med.192:463-474(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor."
Nelson C.A. , Warren J.T. , Wang M.W. , Teitelbaum S.L. , Fremont D.H.
Structure20:1971-1982(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-197 IN COMPLEX WITH TNFSF11/RANKL;DISULFIDE BONDS

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