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Index > Protein center > TRADD(Gene name) > Human
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  • TRADD (Gene name),
  • Tumor necrosis factor receptor type 1-associated DEATH domain protein (Protein name ),  TRADD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TRADD;
    Protein name:
    Tumor necrosis factor receptor type 1-associated DEATH domain protein(TNFR1-associated DEATH domain protein);
    Alternative:
    TNFRSF1A-associated via death domain;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
    Function:
    Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
    Subcellular Location:
    Cytoplasm cytoskeleton
    Protein Attributes:
    Sequence length:
    312
    Sequence:
    50:
    MAAGQNGHEE | WVGSAYLFVE | SSLDKVVLSD | AYAHPQQKVA | VYRALQAALA | 
    100:
    ESGGSPDVLQ | MLKIHRSDPQ | LIVQLRFCGR | QPCGRFLRAY | REGALRAALQ | 
    150:
    RSLAAALAQH | SVPLQLELRA | GAERLDALLA | DEERCLSCIL | AQQPDRLRDE | 
    200:
    ELAELEDALR | NLKCGSGARG | GDGEVASAPL | QPPVPSLSEV | KPPPPPPPAQ | 
    250:
    TFLFQGQPVV | NRPLSLKDQQ | TFARSVGLKW | RKVGRSLQRG | CRALRDPALD | 
    300:
    SLAYEYEREG | LYEQAFQLLR | RFVQAEGRRA | TLQRLVEALE | ENELTSLAED | 
    312:
    LLGLTDPNGG | LA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human TNFR1-associated DEATH domain protein
    ELISA Kit for Human TNFR1-associated DEATH domain protein
    ELISA Kit for Human TNFR1-associated DEATH domain protein
    CLIA Kit for Human TNFR1-associated DEATH domain protein
    CLIA Kit for Human TNFR1-associated DEATH domain protein
    CLIA Kit for Human TNFR1-associated DEATH domain protein
    Polyclonal Antibody for Human TNFR1-associated DEATH domain protein
    Polyclonal Antibody for Human TNFR1-associated DEATH domain protein
    Polyclonal Antibody for Human TNFR1-associated DEATH domain protein
    Monoclonal Antibody for Human TNFR1-associated DEATH domain protein
    Monoclonal Antibody for Human TNFR1-associated DEATH domain protein
    Monoclonal Antibody for Human TNFR1-associated DEATH domain protein
    Protein for Human TNFR1-associated DEATH domain protein
    Protein for Human TNFR1-associated DEATH domain protein
    Protein for Human TNFR1-associated DEATH domain protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation."
      Hsu H. , Xiong J. , Goeddel D.V.
      Cell81:495-504(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Sequence, genomic organisation, and mutation analysis of the human TRADD gene in childhood B- and T-lineage acute lymphoblastic leukemia and ALPS."
      Scheuerpflug C.G. , Dechant M. , Fellenberg J. , Ewerbeck V. , Debatin K.M.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Cloning of the human TRADD gene locus."
      Kaiser C. , Kohstall B. , Kieser A.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Cerebellum.
      tissue: Mammary gland.
    7. 7.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    10. 10.
      "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex."
      Hsu H. , Huang J. , Shu H.-B. , Baichwal V.R. , Goeddel D.V.
      Immunity4:387-396(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK1
    11. 11.
      "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."
      Sanz L. , Sanchez P. , Lallena M.-J. , Diaz-Meco M.T. , Moscat J.
      EMBO J.18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1
    12. 12.
      "The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells."
      Li X. , Wang Y. , Debatin K.-M. , Hug H.
      Biochem. Biophys. Res. Commun.277:513-517(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIPK2
    13. 13.
      "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD."
      Inada H. , Izawa I. , Nishizawa M. , Fujita E. , Kiyono T. , Takahashi T. , Momoi T. , Inagaki M.
      J. Cell Biol.155:415-426(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH KRT14 AND KRT18
    14. 14.
      "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."
      Zhang H. , Zhang R. , Luo Y. , D'Alessio A. , Pober J.S. , Min W.
      J. Biol. Chem.279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2IP
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway."
      Tsao D.H. , McDonagh T. , Telliez J.-B. , Hsu S. , Malakian K. , Xu G.Y. , Lin L.L.
      Mol. Cell5:1051-1057(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-179
    17. 17.
      "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction."
      Park Y.C. , Ye H. , Hsia C. , Segal D. , Rich R.L. , Liou H.C. , Myszka D.G. , Wu H.
      Cell101:777-787(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-179 IN COMPLEX WITH TRAF2
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