TRAF2 ELISA Kit for Human(Homo sapiens) | EIAab.comTRAF2 ELISA Kit for Human(Homo sapiens)

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TRAF2 (Gene name),

TNF receptor-associated factor 2 (Protein name ), TRAF2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TRAF2(TRAP3);

Protein name:

TNF receptor-associated factor 2;

Alternative:

Tumor necrosis factor type 2 receptor-associated protein 3;E3 ubiquitin-protein ligase TRAF2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3 (By similarity). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, DAB2IP, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.

Function:

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

501

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

501:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q12933

KEGG:

hsa:7186

SMR:

Q12933

MIM:

601895

Pfam:

PF00917

UniGene:

Hs.522506

STRING:

9606.ENSP00000247668

Uniprot:

Q12933

FOR

ELISA Kit for Human TNF receptor-associated factor 2

CLIA Kit for Human TNF receptor-associated factor 2

Polyclonal Antibody for Human TNF receptor-associated factor 2

Monoclonal Antibody for Human TNF receptor-associated factor 2

Protein for Human TNF receptor-associated factor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor."
Song H.Y. , Donner D.B.
Biochem. J.309:825-829(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Brain.
tissue: Cerebellum.
tissue: Kidney.
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Endometrium.
4.

SeattleSNPs variation discovery resource
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
tissue: Fetal brain.
tissue: Kidney.
tissue: Leukocyte.
tissue: Stomach.
tissue: Uterus.
8.

"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."
Rothe M. , Wong S.C. , Henzel W.J. , Goeddel D.V.
Cell78:681-692(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-501;INTERACTION WITH TRAF1 AND TNFRSF1B
9.

"T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors."
Lee S.Y. , Park C.G. , Choi Y.
J. Exp. Med.183:669-674(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF8
10.

"I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction."
Rothe M. , Xiong J. , Shu H.-B. , Williamson K. , Goddard A. , Goeddel D.V.
Proc. Natl. Acad. Sci. U.S.A.93:8241-8246(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TANK
11.

"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5."
Hsu H. , Solovyev I. , Colombero A. , Elliott R. , Kelley M. , Boyle W.J.
J. Biol. Chem.272:13471-13474(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF14
12.

"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation."
Lee S.Y. , Lee S.Y. , Choi Y.
J. Exp. Med.185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAIP
13.

"MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."
Malinin N.L. , Boldin M.P. , Kovalenko A.V. , Wallach D.
Nature385:540-544(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K14
14.

"CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."
Pullen S.S. , Miller H.G. , Everdeen D.S. , Dang T.T. , Crute J.J. , Kehry M.R.
Biochemistry37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF5
15.

"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1."
Thome M. , Hofmann K. , Burns K. , Martinon F. , Bodmer J.-L. , Mattmann C. , Tschopp J.
Curr. Biol.8:885-888(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK2
16.

"The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."
Gravestein L.A. , Amsen D. , Boes M. , Calvo C.R. , Kruisbeek A.M. , Borst J.
Eur. J. Immunol.28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD27
17.

"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation."
Kawamata S. , Hori T. , Imura A. , Takaori-Kondo A. , Uchiyama T.
J. Biol. Chem.273:5808-5814(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF4
18.

"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
Wong B.R. , Josien R. , Lee S.Y. , Vologodskaia M. , Steinman R.M. , Choi Y.
J. Biol. Chem.273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF11A
19.

"Binding of CDK9 to TRAF2."
MacLachlan T.K. , Sang N. , De Luca A. , Puri P.L. , Levrero M. , Giordano A.
J. Cell. Biochem.71:467-478(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK9
20.

"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."
Saoulli K. , Lee S.Y. , Cannons J.L. , Yeh W.C. , Santana A. , Goldstein M.D. , Bangia N. , DeBenedette M.A. , Mak T.W. , Choi Y. , Watts T.H.
J. Exp. Med.187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF9
21.

"ASK1 is essential for JNK/SAPK activation by TRAF2."
Nishitoh H. , Saitoh M. , Mochida Y. , Takeda K. , Nakano H. , Rothe M. , Miyazono K. , Ichijo H.
Mol. Cell2:389-395(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K5
22.

"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."
Arch R.H. , Thompson C.B.
Mol. Cell. Biol.18:558-565(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF4 AND TNFRSF9
23.

"NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase."
Pomerantz J.L. , Baltimore D.
EMBO J.18:6694-6704(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBK1
tissue: Spleen.
24.

"Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain."
Bulfone-Paus S. , Bulanova E. , Pohl T. , Budagian V. , Duerkop H. , Rueckert R. , Kunzendorf U. , Paus R. , Krause H.
FASEB J.13:1575-1585(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL15RA
25.

"Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain."
Baud V. , Liu Z.-G. , Bennett B. , Suzuki N. , Xia Y. , Karin M.
Genes Dev.13:1297-1308(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K1;FUNCTION
26.

"Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."
Kwon B. , Yu K.-Y. , Ni J. , Yu G.-L. , Jang I.-K. , Kim Y.-J. , Xing L. , Liu D. , Wang S.-X. , Kwon B.S.
J. Biol. Chem.274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF18
tissue: T-cell.
27.

"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."
Ye X. , Mehlen P. , Rabizadeh S. , VanArsdale T. , Zhang H. , Shin H. , Wang J.J.L. , Leo E. , Zapata J.M. , Hauser C.A. , Reed J.C. , Bredesen D.E.
J. Biol. Chem.274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF16
28.

"TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton."
Fu C.A. , Shen M. , Huang B.C. , Lasaga J. , Payan D.G. , Luo Y.
J. Biol. Chem.274:30729-30737(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNIK
29.

"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
Eby M.T. , Jasmin A. , Kumar A. , Sharma K. , Chaudhary P.M.
J. Biol. Chem.275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF19
30.

"TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."
Pype S. , Declercq W. , Ibrahimi A. , Michiels C. , Van Rietschoten J.G.I. , Dewulf N. , de Boer M. , Vandenabeele P. , Huylebroeck D. , Remacle J.E.
J. Biol. Chem.275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TDP2
31.

"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation."
Xia X.-Z. , Treanor J. , Senaldi G. , Khare S.D. , Boone T. , Kelley M. , Theill L.E. , Colombero A. , Solovyev I. , Lee F. , McCabe S. , Elliott R. , Miner K. , Hawkins N. , Guo J. , Stolina M. , Yu G. , Wang J. , more...
J. Exp. Med.192:137-143(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF13B
32.

"Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress."
Yoneda T. , Imaizumi K. , Oono K. , Yui D. , Gomi F. , Katayama T. , Tohyama M.
J. Biol. Chem.276:13935-13940(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERN1 AND TAOK3
33.

"Stress-induced decrease in TRAF2 stability is mediated by Siah2."
Habelhah H. , Frew I.J. , Laine A. , Janes P.W. , Relaix F. , Sassoon D. , Bowtell D.D.L. , Ronai Z.
EMBO J.21:5756-5765(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH2;DEGRADATION
34.

"Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2."
Chadee D.N. , Yuasa T. , Kyriakis J.M.
Mol. Cell. Biol.22:737-749(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP4K2
35.

"TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2."
Li X. , Yang Y. , Ashwell J.D.
Nature416:345-347(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BIRC2 AND BIRC3;UBIQUITINATION BY BIRC2;DEGRADATION
36.

"CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members."
Trompouki E. , Hatzivassiliou E. , Tsichritzis T. , Farmer H. , Ashworth A. , Mosialos G.
Nature424:793-796(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;DEUBIQUITINATION BY CYLD
37.

"The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination."
Kovalenko A. , Chable-Bessia C. , Cantarella G. , Israeel A. , Wallach D. , Courtois G.
Nature424:801-805(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CYLD;UBIQUITINATION;DEUBIQUITINATION BY CYLD
38.

"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."
Zhang H. , Zhang R. , Luo Y. , D'Alessio A. , Pober J.S. , Min W.
J. Biol. Chem.279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2IP
39.

"TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation."
He L. , Grammer A.C. , Wu X. , Lipsky P.E.
J. Biol. Chem.279:55855-55865(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
40.

"TRAF family proteins link PKR with NF-kappa B activation."
Gil J. , Garcia M.A. , Gomez-Puertas P. , Guerra S. , Rullas J. , Nakano H. , Alcami J. , Esteban M.
Mol. Cell. Biol.24:4502-4512(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EIF2AK2
41.

"VISA is an adapter protein required for virus-triggered IFN-beta Signaling."
Xu L.-G. , Wang Y.-Y. , Han K.-J. , Li L.-Y. , Zhai Z. , Shu H.-B.
Mol. Cell19:727-740(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAVS
42.

"Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation."
Reiley W. , Zhang M. , Wu X. , Granger E. , Sun S.C.
Mol. Cell. Biol.25:3886-3895(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY CYLD
43.

"Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase."
van Vliet C. , Bukczynska P.E. , Puryer M.A. , Sadek C.M. , Shields B.J. , Tremblay M.L. , Tiganis T.
Nat. Immunol.6:253-260(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN2
44.

"Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB."
Tzimas C. , Michailidou G. , Arsenakis M. , Kieff E. , Mosialos G. , Hatzivassiliou E.G.
Cell. Signal.18:83-92(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP48
45.

"RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."
Zhang H. , Zhang H. , Lin Y. , Li J. , Pober J.S. , Min W.
J. Biol. Chem.282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2IP
46.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
47.

"Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2."
Csomos R.A. , Brady G.F. , Duckett C.S.
J. Biol. Chem.284:20531-20539(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BIRC2
48.

"PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination."
Li S. , Wang L. , Dorf M.E.
Mol. Cell33:30-42(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IKKA; IKKB; TAB2 AND TAB3;UBIQUITINATION AT LYS-31;PHOSPHORYLATION AT THR-117;MUTAGENESIS OF THR-117;UBIQUITINATION;SUBCELLULAR LOCATION
49.

"TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis."
Blackwell K. , Zhang L. , Thomas G.S. , Sun S. , Nakano H. , Habelhah H.
Mol. Cell. Biol.29:303-314(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH TNFRSF1A; RIPK1 AND IKKB;MUTAGENESIS OF SER-11;PHOSPHORYLATION AT SER-11
50.

"TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation."
Sondarva G. , Kundu C.N. , Mehrotra S. , Mishra R. , Rangasamy V. , Sathyanarayana P. , Ray R.S. , Rana B. , Rana A.
Cell Res.20:89-98(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP3K11
51.

"Asymmetric recruitment of cIAPs by TRAF2."
Mace P.D. , Smits C. , Vaux D.L. , Silke J. , Day C.L.
J. Mol. Biol.400:8-15(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIRC2;SUBUNIT;HOMOTRIMERIZATION
52.

"The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB."
Zhang L. , Blackwell K. , Shi Z. , Habelhah H.
J. Mol. Biol.396:528-539(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN
53.

"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
Li S. , Lu K. , Wang J. , An L. , Yang G. , Chen H. , Cui Y. , Yin X. , Xie P. , Xing G. , He F. , Zhang L.
Mol. Cell. Biochem.338:11-17(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;FUNCTION
54.

"Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway."
Sasai M. , Tatematsu M. , Oshiumi H. , Funami K. , Matsumoto M. , Hatakeyama S. , Seya T.
Mol. Immunol.47:1283-1291(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1;FUNCTION
55.

"Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2."
Alvarez S.E. , Harikumar K.B. , Hait N.C. , Allegood J. , Strub G.M. , Kim E.Y. , Maceyka M. , Jiang H. , Luo C. , Kordula T. , Milstien S. , Spiegel S.
Nature465:1084-1088(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;UBIQUITINATION;INTERACTION WITH SPHK1;SPHINGOLIPID BINDING
56.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
57.

"Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes."
Shembade N. , Ma A. , Harhaj E.W.
Science327:1135-1139(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFAIP3
58.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
59.

"Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."
Scudiero I. , Zotti T. , Ferravante A. , Vessichelli M. , Vito P. , Stilo R.
J. Cell. Physiol.226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD14
60.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7; SER-11 AND THR-22;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
61.

"IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."
Zhou A.Y. , Shen R.R. , Kim E. , Lock Y.J. , Xu M. , Chen Z.J. , Hahn W.C.
Cell Rep.3:724-733(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IKBKE UBIQUITINATION
62.

"Structural basis for self-association and receptor recognition of human TRAF2."
Park Y.C. , Burkitt V. , Villa A.R. , Tong L. , Wu H.
Nature398:533-538(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 310-501 IN COMPLEX WITH TNFRSF1B
63.

"Crystallographic analysis of CD40 recognition and signaling by human TRAF2."
McWhirter S.M. , Pullen S.S. , Holton J.M. , Crute J.J. , Kehry M.R. , Alber T.
Proc. Natl. Acad. Sci. U.S.A.96:8408-8413(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH EBV BNFL1;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 315-501 IN COMPLEX WITH TNFRSF5;X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF4;X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 334-501 IN COMPLEX WITH TNFRSF9
64.

"A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction."
Park Y.C. , Ye H. , Hsia C. , Segal D. , Rich R.L. , Liou H.C. , Myszka D.G. , Wu H.
Cell101:777-787(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 331-501 IN COMPLEX WITH TRADD
65.

"Structural basis for the lack of E2 interaction in the RING domain of TRAF2."
Yin Q. , Lamothe B. , Darnay B.G. , Wu H.
Biochemistry48:10558-10567(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-133;FUNCTION;SUBUNIT
66.

"Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation."
Zheng C. , Kabaleeswaran V. , Wang Y. , Cheng G. , Wu H.
Mol. Cell38:101-113(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 266-330 IN COMPLEXES WITH TRAF1 AND BIRC3;FUNCTION;SUBUNIT;COILED-COIL DOMAIN;MUTAGENESIS OF ILE-285; VAL-288 AND GLU-292

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