Protein name:
Tripartite motif-containing protein 72 ;
Alternative:
Mitsugumin-53 (Mg53) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homooligomer; disulfide-linked. Interacts with DYSF and CAV3.
Function:
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
Subcellular Location:
Cell membrane
sarcolemma
Cytoplasmic vesicle membrane
Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
Protein Attributes:
50:
MSTAPGLLRQ | ELSCPLCLQL | FDAPVTAECG | HSFCRACLIR | VAGEPADDGT |
100:
VACPCCQAST | RPQALSTNLQ | LARLVEGLAQ | VPQGHCEEHL | DPLSIYCEQD |
150:
RTLVCGVCAS | LGSHRGHRLL | PAAEAHARLK | TQLPQQKAQL | QEACMRKEKS |
200:
VAVLEHQLVE | VEETVRQFRG | AVGEQLGKMR | MFLAALESSL | DREAERVRGE |
250:
AGVALRRELS | SLNSYLEQLR | QMEKVLEEVA | DKPQTEFLMK | FCLVTSRLQK |
300:
ILSESPPPAR | LDIQLPVISD | DFKFQVWKKM | FRALMPELEE | LTFDPSSAHP |
350:
SLVVSASGRR | VECSEQKAPP | AGEDTCQFDK | TVAVVAKQLL | SQGEHYWEVE |
400:
VGDKPRWALG | VMAADASRRG | RLHAVPSQGL | WLLGLRDGKI | LEAHVEAKEP |
450:
RALRTPERPP | ARIGLYLSFA | DGVLTFYDAS | NTDALTPLFS | FHERLPGPVY |
477:
PMFDVCWHDK | GKNSQPLLLV | GPDSEQA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
ELISA Kit for Rat Tripartite motif-containing protein 72
ELISA Kit for Rat Tripartite motif-containing protein 72
ELISA Kit for Rat Tripartite motif-containing protein 72
ELISA Kit for Rat Tripartite motif-containing protein 72
CLIA Kit for Rat Tripartite motif-containing protein 72
CLIA Kit for Rat Tripartite motif-containing protein 72
CLIA Kit for Rat Tripartite motif-containing protein 72
CLIA Kit for Rat Tripartite motif-containing protein 72
Polyclonal Antibody for Rat Tripartite motif-containing protein 72
Polyclonal Antibody for Rat Tripartite motif-containing protein 72
Polyclonal Antibody for Rat Tripartite motif-containing protein 72
Polyclonal Antibody for Rat Tripartite motif-containing protein 72
Monoclonal Antibody for Rat Tripartite motif-containing protein 72
Monoclonal Antibody for Rat Tripartite motif-containing protein 72
Monoclonal Antibody for Rat Tripartite motif-containing protein 72
Monoclonal Antibody for Rat Tripartite motif-containing protein 72
Protein for Rat Tripartite motif-containing protein 72
Protein for Rat Tripartite motif-containing protein 72
Protein for Rat Tripartite motif-containing protein 72
Protein for Rat Tripartite motif-containing protein 72
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Heart .