TRIP12 ELISA Kit for Human(Homo sapiens) | EIAab.comTRIP12 ELISA Kit for Human(Homo sapiens) | EIAab.com

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TRIP12 (Gene name),

Probable E3 ubiquitin-protein ligase TRIP12 (Protein name ), TRIPC_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

TRIP12(KIAA0045;ULF);

Protein name:

Probable E3 ubiquitin-protein ligase TRIP12;

Alternative:

Thyroid receptor-interacting protein 12(TR-interacting protein 12);Thyroid receptor-interacting protein 12(TR-interacting protein 12;TRIP-12);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

PA700 is composed of at least 16 distinct peptides ranging from 20-112 kDa.

Function:

Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1992

Sequence:

50:

MSNRPNNNPG | GSLRRSQRNT | AGAQPQDDSI | GGRSCSSSSA | VIVPQPEDPD |

100:

RANTSERQKT | GQVPKKDNSR | GVKRSASPDY | NRTNSPSSAK | KPKALQHTES |

150:

PSETNKPHSK | SKKRHLDQEQ | QLKSAQSPST | SKAHTRKSGA | TGGSRSQKRK |

200:

RTESSCVKSG | SGSESTGAEE | RSAKPTKLAS | KSATSAKAGC | STITDSSSAA |

250:

STSSSSSAVA | SASSTVPPGA | RVKQGKDQNK | ARRSRSASSP | SPRRSSREKE |

300:

QSKTGGSSKF | DWAARFSPKV | SLPKTKLSLP | GSSKSETSKP | GPSGLQAKLA |

350:

SLRKSTKKRS | ESPPAELPSL | RRSTRQKTTG | SCASTSRRGS | GLGKRGAAEA |

400:

RRQEKMADPE | SNQEAVNSSA | ARTDEAPQGA | AGAVGMTTSG | ESESDDSEMG |

450:

RLQALLEARG | LPPHLFGPLG | PRMSQLFHRT | IGSGASSKAQ | QLLQGLQASD |

500:

ESQQLQAVIE | MCQLLVMGNE | ETLGGFPVKS | VVPALITLLQ | MEHNFDIMNH |

550:

ACRALTYMME | ALPRSSAVVV | DAIPVFLEKL | QVIQCIDVAE | QALTALEMLS |

600:

RRHSKAILQA | GGLADCLLYL | EFFSINAQRN | ALAIAANCCQ | SITPDEFHFV |

650:

ADSLPLLTQR | LTHQDKKSVE | STCLCFARLV | DNFQHEENLL | QQVASKDLLT |

700:

NVQQLLVVTP | PILSSGMFIM | VVRMFSLMCS | NCPTLAVQLM | KQNIAETLHF |

750:

LLCGASNGSC | QEQIDLVPRS | PQELYELTSL | ICELMPCLPK | EGIFAVDTML |

800:

KKGNAQNTDG | AIWQWRDDRG | LWHPYNRIDS | RIIEQINEDT | GTARAIQRKP |

850:

NPLANSNTSG | YSESKKDDAR | AQLMKEDPEL | AKSFIKTLFG | VLYEVYSSSA |

900:

GPAVRHKCLR | AILRIIYFAD | AELLKDVLKN | HAVSSHIASM | LSSQDLKIVV |

950:

GALQMAEILM | QKLPDIFSVY | FRREGVMHQV | KHLAESESLL | TSPPKACTNG |

1000:

SGSMGSTTSV | SSGTATAATH | AAADLGSPSL | QHSRDDSLDL | SPQGRLSDVL |

1050:

KRKRLPKRGP | RRPKYSPPRD | DDKVDNQAKS | PTTTQSPKSS | FLASLNPKTW |

1100:

GRLSTQSNSN | NIEPARTAGG | SGLARAASKD | TISNNREKIK | GWIKEQAHKF |

1150:

VERYFSSENM | DGSNPALNVL | QRLCAATEQL | NLQVDGGAEC | LVEIRSIVSE |

1200:

SDVSSFEIQH | SGFVKQLLLY | LTSKSEKDAV | SREIRLKRFL | HVFFSSPLPG |

1250:

EEPIGRVEPV | GNAPLLALVH | KMNNCLSQME | QFPVKVHDFP | SGNGTGGSFS |

1300:

LNRGSQALKF | FNTHQLKCQL | QRHPDCANVK | QWKGGPVKID | PLALVQAIER |

1350:

YLVVRGYGRV | REDDEDSDDD | GSDEEIDESL | AAQFLNSGNV | RHRLQFYIGE |

1400:

HLLPYNMTVY | QAVRQFSIQA | EDERESTDDE | SNPLGRAGIW | TKTHTIWYKP |

1450:

VREDEESNKD | CVGGKRGRAQ | TAPTKTSPRN | AKKHDELWHD | GVCPSVSNPL |

1500:

EVYLIPTPPE | NITFEDPSLD | VILLLRVLHA | ISRYWYYLYD | NAMCKEIIPT |

1550:

SEFINSKLTA | KANRQLQDPL | VIMTGNIPTW | LTELGKTCPF | FFPFDTRQML |

1600:

FYVTAFDRDR | AMQRLLDTNP | EINQSDSQDS | RVAPRLDRKK | RTVNREELLK |

1650:

QAESVMQDLG | SSRAMLEIQY | ENEVGTGLGP | TLEFYALVSQ | ELQRADLGLW |

1700:

RGEEVTLSNP | KGSQEGTKYI | QNLQGLFALP | FGRTAKPAHI | AKVKMKFRFL |

1750:

GKLMAKAIMD | FRLVDLPLGL | PFYKWMLRQE | TSLTSHDLFD | IDPVVARSVY |

1800:

HLEDIVRQKK | RLEQDKSQTK | ESLQYALETL | TMNGCSVEDL | GLDFTLPGFP |

1850:

NIELKKGGKD | IPVTIHNLEE | YLRLVIFWAL | NEGVSRQFDS | FRDGFESVFP |

1900:

LSHLQYFYPE | ELDQLLCGSK | ADTWDAKTLM | ECCRPDHGYT | HDSRAVKFLF |

1950:

EILSSFDNEQ | QRLFLQFVTG | SPRLPVGGFR | SLNPPLTIVR | KTFESTENPD |

1992:

DFLPSVMTCV | NYLKLPDYSS | IEIMREKLLI | AAREGQQSFH | LS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

UniGene:

MIM:

KEGG:

Pfam:

SMR:

UniGene:

STRING:

9606.ENSP00000283943

Uniprot:

FOR

ELISA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

ELISA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

ELISA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

ELISA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

CLIA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

CLIA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

CLIA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

CLIA Kit for Human Probable E3 ubiquitin-protein ligase TRIP12

Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Polyclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Monoclonal Antibody for Human Probable E3 ubiquitin-protein ligase TRIP12

Protein for Human Probable E3 ubiquitin-protein ligase TRIP12

Protein for Human Probable E3 ubiquitin-protein ligase TRIP12

Protein for Human Probable E3 ubiquitin-protein ligase TRIP12

Protein for Human Probable E3 ubiquitin-protein ligase TRIP12

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses."
Chen D. , Shan J. , Zhu W.G. , Qin J. , Gu W.
Nature464:624-627(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MYC AND CDKN2A;MUTAGENESIS OF CYS-1959
2.

"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
Nomura N. , Nagase T. , Miyajima N. , Sazuka T. , Tanaka A. , Sato S. , Seki N. , Kawarabayasi Y. , Ishikawa K. , Tabata S.
DNA Res.1:223-229(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Bone marrow.
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
5.

"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
Lee J.W. , Choi H.-S. , Gyuris J. , Brent R. , Moore D.D.
Mol. Endocrinol.9:243-254(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1801-1992
6.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1317;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"TRIP12 functions as an E3 ubiquitin ligase of APP-BP1."
Park Y. , Yoon S.K. , Yoon J.B.
Biochem. Biophys. Res. Commun.374:294-298(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310; SER-312; SER-991; SER-997; SER-1317 AND SER-1322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway."
Park Y. , Yoon S.K. , Yoon J.B.
J. Biol. Chem.284:1540-1549(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-991; SER-1317 AND SER-1322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex."
Keppler B.R. , Archer T.K.
J. Biol. Chem.285:35665-35674(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMARCC1
14.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-312 AND SER-942;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-310; SER-1030; SER-1317 AND SER-1322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
17.

"TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes."
Gudjonsson T. , Altmeyer M. , Savic V. , Toledo L. , Dinant C. , Grofte M. , Bartkova J. , Poulsen M. , Oka Y. , Bekker-Jensen S. , Mailand N. , Neumann B. , Heriche J.K. , Shearer R. , Saunders D. , Bartek J. , Lukas J. , Lukas C.
Cell150:697-709(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation."
Chio I.I. , Sasaki M. , Ghazarian D. , Moreno J. , Done S. , Ueda T. , Inoue S. , Chang Y.L. , Chen N.J. , Mak T.W.
Nat. Cell Biol.14:625-633(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRADD
19.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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