Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > Trip12(Gene name) > Rat
  • Add your favorite
  • Trip12 (Gene name),
  • E3 ubiquitin-protein ligase TRIP12 (Protein name ),  TRIPC_RAT from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    Trip12;
    Protein name:
    E3 ubiquitin-protein ligase TRIP12;
    Alternative:
    Thyroid receptor-interacting protein 12(TR-interacting protein 12);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.
    Function:
    E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
    Subcellular Location:
    Nucleus Nucleoplasm
    Protein Attributes:
    Sequence length:
    2025
    Sequence:
    50:
    MSNRPNNNPG | GSLRRSQRNT | AGAQPQDDSI | GGRSCSSSSA | VIVPQPEDPD | 
    100:
    RANTSERQKT | GQVPKKDNSR | GVKRSASPDY | NRTNSPSSAK | KPRAFQHIES | 
    150:
    LSETNKPPSK | SKKRHLDQEQ | QLKSAQLPST | SKAHTRKSVA | AGSSRSQKRK | 
    200:
    RTESSCVKSG | SGSESTGAEE | RSAKPTKLAS | KSATSAKAGC | STITDSSSAA | 
    250:
    STSSSSSAVA | SASSTVPAGA | RVKQGKDQNK | ARRSRSASSP | SPRRSSREKE | 
    300:
    QSKTGGSSKF | DWAARFSPKV | SLPKTKLSLP | GSSKSETSKP | GPSGLQAKLA | 
    350:
    SLRKSTKKRS | ESPPAELPSL | RRSTRQKTTG | SCASTSRRGS | GLGKRGAAEA | 
    400:
    RRQEKMADPE | GNQETVNSSA | ARTDEAPQGA | AASSSVAGAV | GMTTSGESES | 
    450:
    DDSEMGRLQA | LLEARGLPPH | LFGPLGPRMS | QLFHRTIGSG | ASSKAQQLLQ | 
    500:
    GLQASDESQQ | LQAVIEMCQL | LVMGNEETLG | GFPVKSVVPA | LITLLQMEHN | 
    550:
    FDIMNHACRA | LTYMMEALPR | SSAVVVDAIP | VFLEKLQVIQ | CIDVAEQALT | 
    600:
    ALEMLSRRHS | KAILQAGGLA | DCLLYLEFFS | INAQRNALAI | AANCCQSITP | 
    650:
    DEFHFVADSL | PLLTQRLTHQ | DKKSVESTCL | CFARLVDNFQ | HEENLLQQVA | 
    700:
    SKDLLTNVQQ | LLVVTPPILS | SGMFIMVVRM | FSLMCSNCPT | LAVQLMKQNI | 
    750:
    AETLHFLLCG | ASNGSCQEQI | DLVPRSPQEL | YELTSLICEL | MPCLPKEGIF | 
    800:
    AVDTMLKKGN | AQNTDGAIWQ | WRDDRGLWHP | YNRIDSRIIE | AAHQVGEDEI | 
    850:
    SLSTLGRVYT | IDFNSMQQIN | EDTGTARAIQ | RKPNPLANTN | TSGYSDLKKD | 
    900:
    DARAQLMKED | PELAKSFIKT | LFGVLYEVYS | SSAGPAVRHK | CLRAILRIIY | 
    950:
    FADAELLKDV | LKNHAVSSHI | ASMLSSQDLK | IVVGALQMAE | ILMQKLPDIF | 
    1000:
    SVYFRREGVM | HQVKHLAESE | SLLTSPPKAC | TNGSGSLGST | TPASSGTATA | 
    1050:
    ATNASADLGS | PSLQHSRDDS | LDLSPQGRLS | DVLKRKRLPK | RGPRRPKYSP | 
    1100:
    PRDDDKVDNQ | AKSPTTTQSP | KSSFLASLNP | KTWGRLSAQS | NSNNIEPART | 
    1150:
    AGVSGLARAA | SKDTISNNRE | KIKGWIKEQA | HKFVERYFSS | ENMDGSNPAL | 
    1200:
    NVLQRLCAAT | EQLNLQVDGG | AECLVEIRSI | VSESDVSSFE | IQHSGFVKQL | 
    1250:
    LLYLTSKSEK | DAVSREIRLK | RFLHVFFSSP | LPGEEPVGRV | EPVGHAPLLA | 
    1300:
    LVHKMNNCLS | QMEQFPVKVH | DFPSGNGSGG | SFSLNRGSQA | LKFFNTHQLK | 
    1350:
    CQLQRHPDCA | NVKQWKGGPV | KIDPLALVQA | IERYLVVRGY | GRVREDDEDS | 
    1400:
    DDDGSDEEID | ESLAAQFLNS | GNVRHRLQFY | IGEHLLPYNM | TVYQAVRQFS | 
    1450:
    VQAEDEREST | DDESNPLGRA | GIWTKTHTIW | YKPVREDEES | SKDCVGGKRG | 
    1500:
    RAQTAPTKTS | PRNAKKHDEL | WHDGVCPSVA | NPLEVYLIPT | PPENITFEDP | 
    1550:
    SLDVILLLRV | LHAISRYWYY | LYDNAMCKEI | IPTSEFINSK | LTAKANRQLQ | 
    1600:
    DPLVIMTGNI | PTWLTELGKT | CPFFFPFDTR | QMLFYVTAFD | RDRAMQRLLD | 
    1650:
    TNPEINQSDS | QDSRVAPRLD | RKKRTVNREE | LLKQAESVMQ | DLGSSRAMLE | 
    1700:
    IQYENEVGTG | LGPTLEFYAL | VSQELQRADL | GLWRGEEVTL | SNPKGSQEGT | 
    1750:
    KYIQNLQGLF | ALPFGRTAKP | AHIAKVKMKF | RFLGKLMAKA | IMDFRLVDLP | 
    1800:
    LGLPFYKWML | RQETSLTSHD | LFDIDPVVAR | SVYHLEDIVR | QKKRLEQDKS | 
    1850:
    QTKESLQYAL | ETLTMNGCSV | EDLGLDFTLP | GFPNIELKKG | GKDIPVTIHN | 
    1900:
    LEEYLRLVIF | WALNEGVCRQ | FDSFRDGFES | VFPLSHLQYF | YPEELDQLLC | 
    1950:
    GSKADTWDAK | TLMECCRPDH | GYTHDSRAVK | FLFEILSSFD | NEQQRLFLQF | 
    2000:
    VTGSPRLPVG | GFRSLNPPLT | IVRKTFESTE | NPDDFLPSVM | TCVNYLKLPD | 
    2025:
    YSSIEIMRDK | LLIAAREGQQ | SFHLS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    ELISA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    ELISA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    ELISA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    CLIA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    CLIA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    CLIA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    CLIA Kit for Rat E3 ubiquitin-protein ligase TRIP12
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase TRIP12
    Protein for Rat E3 ubiquitin-protein ligase TRIP12
    Protein for Rat E3 ubiquitin-protein ligase TRIP12
    Protein for Rat E3 ubiquitin-protein ligase TRIP12
    Protein for Rat E3 ubiquitin-protein ligase TRIP12

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Liver.
      tissue: Prostate.
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter