Gene name:
Trpa1 (Anktm1) ;
Protein name:
Transient receptor potential cation channel subfamily A member 1 ;
Alternative:
Ankyrin-like with transmembrane domains protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MKRGLRRILL | PEERKEVQGV | VYRGVGEDMD | CSKESFKVDI | EGDMCRLEDF |
100:
IKNRRKLSKY | EDENLCPLHH | AAAEGQVELM | ELIINGSSCE | VLNIMDGYGN |
150:
TPLHCAAEKN | QVESVKFLLS | QGANPNLRNR | NMMSPLHIAV | HGMYNEVIKV |
200:
LTEHKATNIN | LEGENGNTAL | MSTCAKDNSE | ALQILLEKGA | KLCKSNKWGD |
250:
YPVHQAAFSG | AKKCMELILA | YGEKNGYSRE | THINFVNHKK | ASPLHLAVQS |
300:
GDLDMIKMCL | DNGAHIDMME | NAKCMALHFA | ATQGATDIVK | LMISSYTGSS |
350:
DIVNAVDGNQ | ETLLHRASLF | DHHDLAEYLI | SVGADINSTD | SEGRSPLILA |
400:
TASASWNIVN | LLLCKGAKVD | IKDHLGRNFL | HLTVQQPYGL | RNLRPEFMQM |
450:
QHIKELVMDE | DNDGCTPLHY | ACRQGVPVSV | NNLLGFNVSI | HSKSKDKKSP |
500:
LHFAASYGRI | NTCQRLLQDI | SDTRLLNEGD | LHGMTPLHLA | AKNGHDKVVQ |
550:
LLLKKGALFL | SDHNGWTALH | HASMGGYTQT | MKVILDTNLK | CTDRLDEEGN |
600:
TALHFAAREG | HAKAVAMLLS | YNADILLNKK | QASFLHIALH | NKRKEVVLTT |
650:
IRNKRWDECL | QVFTHNSPSN | RCPIMEMVEY | LPECMKVLLD | FCMIPSTEDK |
700:
SCQDYHIEYN | FKYLQCPLSM | TKKVAPTQDV | VYEPLTILNV | MVQHNRIELL |
750:
NHPVCREYLL | MKWCAYGFRA | HMMNLGSYCL | GLIPMTLLVV | KIQPGMAFNS |
800:
TGIINGTSST | HEERIDTLNS | FPIKICMILV | FLSSIFGYCK | EVIQIFQQKR |
850:
NYFLDYNNAL | EWVIYTTSII | FVLPLFLNIP | AYMQWQCGAI | AIFFYWMNFL |
900:
LYLQRFENCG | IFIVMLEVIF | KTLLRSTGVF | IFLLLAFGLS | FYVLLNFQDA |
950:
FSTPLLSLIQ | TFSMMLGDIN | YRDAFLEPLF | RNELAYPVLT | FGQLIAFTMF |
1000:
VPIVLMNLLI | GLAVGDIAEV | QKHASLKRIA | MQVELHTNLE | KKLPLWYLRK |
1050:
VDQRSTIVYP | NRPRHGRMLR | FFHYFLNMQE | TRQEVPNIDT | CLEMEILKQK |
1100:
YRLKDLTSLL | EKQHELIKLI | IQKMEIISET | EDEDNHCSFQ | DRFKKERLEQ |
1125:
MHSKWNFVLN | AVKTKTHCSI | SHPDF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
Protein for Mouse Transient receptor potential cation channel subfamily A member 1
Protein for Mouse Transient receptor potential cation channel subfamily A member 1
Protein for Mouse Transient receptor potential cation channel subfamily A member 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures."
Story G.M.
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Peier A.M.
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Reeve A.J.
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Cell112:819-829(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
strain :
C57BL/6 .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Corpora quadrigemina .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
4.
"TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells."
Corey D.P.
,
Garcia-Anoveros J.
,
Holt J.R.
,
Kwan K.Y.
,
Lin S.-Y.
,
Vollrath M.A.
,
Amalfitano A.
,
Cheung E.-L.M.
,
Derfler B.H.
,
Duggan A.
,
Geleoc G.S.G.
,
Gray P.A.
,
Hoffman M.P.
,
Rehm H.L.
,
Tamasauskas D.
,
Zhang D.-S.
Nature432:723-730(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ELECTRON MICROSCOPY (16 ANGSTROMS);SUBUNIT