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Index > Protein center > Trpa1(Gene name) > Mouse
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  • Trpa1 (Gene name),
  • Transient receptor potential cation channel subfamily A member 1 (Protein name ),  TRPA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Trpa1(Anktm1);
    Protein name:
    Transient receptor potential cation channel subfamily A member 1;
    Alternative:
    Ankyrin-like with transmembrane domains protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1125
    Sequence:
    50:
    MKRGLRRILL | PEERKEVQGV | VYRGVGEDMD | CSKESFKVDI | EGDMCRLEDF | 
    100:
    IKNRRKLSKY | EDENLCPLHH | AAAEGQVELM | ELIINGSSCE | VLNIMDGYGN | 
    150:
    TPLHCAAEKN | QVESVKFLLS | QGANPNLRNR | NMMSPLHIAV | HGMYNEVIKV | 
    200:
    LTEHKATNIN | LEGENGNTAL | MSTCAKDNSE | ALQILLEKGA | KLCKSNKWGD | 
    250:
    YPVHQAAFSG | AKKCMELILA | YGEKNGYSRE | THINFVNHKK | ASPLHLAVQS | 
    300:
    GDLDMIKMCL | DNGAHIDMME | NAKCMALHFA | ATQGATDIVK | LMISSYTGSS | 
    350:
    DIVNAVDGNQ | ETLLHRASLF | DHHDLAEYLI | SVGADINSTD | SEGRSPLILA | 
    400:
    TASASWNIVN | LLLCKGAKVD | IKDHLGRNFL | HLTVQQPYGL | RNLRPEFMQM | 
    450:
    QHIKELVMDE | DNDGCTPLHY | ACRQGVPVSV | NNLLGFNVSI | HSKSKDKKSP | 
    500:
    LHFAASYGRI | NTCQRLLQDI | SDTRLLNEGD | LHGMTPLHLA | AKNGHDKVVQ | 
    550:
    LLLKKGALFL | SDHNGWTALH | HASMGGYTQT | MKVILDTNLK | CTDRLDEEGN | 
    600:
    TALHFAAREG | HAKAVAMLLS | YNADILLNKK | QASFLHIALH | NKRKEVVLTT | 
    650:
    IRNKRWDECL | QVFTHNSPSN | RCPIMEMVEY | LPECMKVLLD | FCMIPSTEDK | 
    700:
    SCQDYHIEYN | FKYLQCPLSM | TKKVAPTQDV | VYEPLTILNV | MVQHNRIELL | 
    750:
    NHPVCREYLL | MKWCAYGFRA | HMMNLGSYCL | GLIPMTLLVV | KIQPGMAFNS | 
    800:
    TGIINGTSST | HEERIDTLNS | FPIKICMILV | FLSSIFGYCK | EVIQIFQQKR | 
    850:
    NYFLDYNNAL | EWVIYTTSII | FVLPLFLNIP | AYMQWQCGAI | AIFFYWMNFL | 
    900:
    LYLQRFENCG | IFIVMLEVIF | KTLLRSTGVF | IFLLLAFGLS | FYVLLNFQDA | 
    950:
    FSTPLLSLIQ | TFSMMLGDIN | YRDAFLEPLF | RNELAYPVLT | FGQLIAFTMF | 
    1000:
    VPIVLMNLLI | GLAVGDIAEV | QKHASLKRIA | MQVELHTNLE | KKLPLWYLRK | 
    1050:
    VDQRSTIVYP | NRPRHGRMLR | FFHYFLNMQE | TRQEVPNIDT | CLEMEILKQK | 
    1100:
    YRLKDLTSLL | EKQHELIKLI | IQKMEIISET | EDEDNHCSFQ | DRFKKERLEQ | 
    1125:
    MHSKWNFVLN | AVKTKTHCSI | SHPDF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    ELISA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    CLIA Kit for Mouse Transient receptor potential cation channel subfamily A member 1
    Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Polyclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Monoclonal Antibody for Mouse Transient receptor potential cation channel subfamily A member 1
    Protein for Mouse Transient receptor potential cation channel subfamily A member 1
    Protein for Mouse Transient receptor potential cation channel subfamily A member 1
    Protein for Mouse Transient receptor potential cation channel subfamily A member 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures."
      Story G.M. , Peier A.M. , Reeve A.J. , Eid S.R. , Mosbacher J. , Hricik T.R. , Earley T.J. , Hergarden A.C. , Anderson D.A. , Hwang S.W. , McIntyre P. , Jegla T. , Bevan S. , Patapoutian A.
      Cell112:819-829(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      strain: C57BL/6.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "Cold-sensitive, menthol-insensitive neurons in the murine sympathetic nervous system."
      Smith M.P. , Beacham D. , Ensor E. , Koltzenburg M.
      NeuroReport15:1399-1403(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin."
      Bandell M. , Story G.M. , Hwang S.W. , Viswanath V. , Eid S.R. , Petrus M.J. , Earley T.J. , Patapoutian A.
      Neuron41:849-857(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing."
      Nagata K. , Duggan A. , Kumar G. , Garcia-Anoveros J.
      J. Neurosci.25:4052-4061(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents."
      Bautista D.M. , Jordt S.E. , Nikai T. , Tsuruda P.R. , Read A.J. , Poblete J. , Yamoah E.N. , Basbaum A.I. , Julius D.
      Cell124:1269-1282(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    9. 9.
      "Identification of in vivo disulfide conformation of TRPA1 ion channel."
      Wang L. , Cvetkov T.L. , Chance M.R. , Moiseenkova-Bell V.Y.
      J. Biol. Chem.287:6169-6176(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    10. 10.
      "Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy."
      Cvetkov T.L. , Huynh K.W. , Cohen M.R. , Moiseenkova-Bell V.Y.
      J. Biol. Chem.286:38168-38176(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON MICROSCOPY (16 ANGSTROMS);SUBUNIT
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