TRPM2 ELISA Kit for Human(Homo sapiens) | EIAab.comTRPM2 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > TRPM2(Gene name) > Human

TRPM2 (Gene name),

Transient receptor potential cation channel subfamily M member 2 (Protein name ), TRPM2_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

TRPM2(EREG1;KNP3;LTRPC2;TRPC7);

Protein name:

Transient receptor potential cation channel subfamily M member 2;

Alternative:

Long transient receptor potential channel 2(LTrpC-2;LTrpC2);Estrogen-responsive element-associated gene 1 protein;Transient receptor potential channel 7(TrpC7);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.

Function:

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1503

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1503:

AHY

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000300482

MIM:

603749

SMR:

O94759

Pfam:

PF00520

String:

O94759

KEGG:

hsa:7226

UniGene:

Hs.369759

Uniprot:

O94759

FOR

ELISA Kit for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

E12145h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

E12145m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

U12145m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

U12145h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

P12145Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2

Cat.:

P12145Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2

Protein for Human Transient receptor potential cation channel subfamily M member 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain."
Nagamine K. , Kudoh J. , Minoshima S. , Kawasaki K. , Asakawa S. , Ito F. , Shimizu N.
Genomics54:124-131(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
tissue: Brain.
2.

"Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose."
Wehage E. , Eisfeld J. , Heiner I. , Juengling E. , Zitt C. , Lueckhoff A.
J. Biol. Chem.277:23150-23156(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ARG-1189;REGULATION BY OXIDATIVE STRESS
tissue: Promyelocytic leukemia.
3.

"A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death."
Zhang W. , Chu X. , Tong Q. , Cheung J.Y. , Conrad K. , Masker K. , Miller B.A.
J. Biol. Chem.278:16222-16229(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANT ARG-1189;INTERACTION BETWEEN ISOFORMS 1 AND 3;SUBCELLULAR LOCATION
tissue: Bone marrow.
4.

"Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum."
Uemura T. , Kudoh J. , Noda S. , Kanba S. , Shimizu N.
Biochem. Biophys. Res. Commun.328:1232-1243(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
tissue: Brain.
5.

"Cloning of the human TRPM2."
Hayes P.D.
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
6.

NIEHS SNPs program
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-52; ILE-166; MET-385; GLU-543; GLU-780; TRP-1199; GLY-1201; SER-1249; MET-1347; LYS-1359; MET-1368 AND SER-1438
7.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"Molecular cloning of a novel estrogen responsive gene, estrogen responsive element associated gene 1 (EREG1), which contains MutT like domain."
Hiroi H. , Muramatsu M. , Inoue S.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1190-1503
10.

"ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology."
Perraud A.-L. , Fleig A. , Dunn C.A. , Bagley L.A. , Launay P. , Schmitz C. , Stokes A.J. , Zhu Q. , Bessman M.J. , Penner R. , Kinet J.-P. , Scharenberg A.M.
Nature411:595-599(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;REGULATION BY ADP-RIBOSE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
11.

"Immunocyte Ca2+ influx system mediated by LTRPC2."
Sano Y. , Inamura K. , Miyake A. , Mochizuki S. , Yokoi H. , Matsushime H. , Furuichi K.
Science293:1327-1330(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY PYRIMIDINE NUCLEOTIDES;TISSUE SPECIFICITY
12.

"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."
Hara Y. , Wakamori M. , Ishii M. , Maeno E. , Nishida M. , Yoshida T. , Yamada H. , Shimizu S. , Mori E. , Kudoh J. , Shimizu N. , Kurose H. , Okada Y. , Imoto K. , Mori Y.
Mol. Cell9:163-173(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF MET-1397

Product Feedback Wall

* Email:
*Comments: