TRPM7 ELISA Kit for Human(Homo sapiens) | EIAab.comTRPM7 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TRPM7(Gene name) > Human

TRPM7 (Gene name),

Transient receptor potential cation channel subfamily M member 7 (Protein name ), TRPM7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TRPM7(CHAK1;LTRPC7);

Protein name:

Transient receptor potential cation channel subfamily M member 7;

Alternative:

Long transient receptor potential channel 7(LTrpC-7;LTrpC7);Channel-kinase 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.

Function:

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1865

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1865:

STKESESTNS | VRLML

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

105500

Pfam:

PF02816

STRING:

9606.ENSP00000320239

SMR:

Q96QT4

String:

Q96QT4

UniGene:

Hs.512894

KEGG:

hsa:54822

Uniprot:

Q96QT4

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ELISA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

E12150h

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96T

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ELISA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

E12150r

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Packing:

96T

ELISA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

E12150m

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Packing:

96T

CLIA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

U12150m

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MSDS:

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Packing:

96T

CLIA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

U12150r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

U12150h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

P12150Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

P12150Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 7

Cat.:

P12150Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Transient receptor potential cation channel subfamily M member 7

Protein for Human Transient receptor potential cation channel subfamily M member 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability."
Nadler M.J.S. , Hermosura M.C. , Inabe K. , Perraud A.-L. , Zhu Q. , Stokes A.J. , Kurosaki T. , Kinet J.-P. , Penner R. , Scharenberg A.M. , Fleig A.
Nature411:590-595(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
2.

Nadler M.J.S. , Hermosura M.C. , Inabe K. , Perraud A.-L. , Zhu Q. , Stokes A.J. , Kurosaki T. , Kinet J.-P. , Penner R. , Scharenberg A.M. , Fleig A.
Nature412:660-660(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel."
Ryazanova L.V. , Dorovkov M.V. , Ansari A. , Ryazanov A.G.
J. Biol. Chem.279:3708-3716(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-575 AND 1096-1865;VARIANT ILE-1482
tissue: Colon.
tissue: Placenta.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-998
tissue: Liver.
6.

"Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7."
Schmitz C. , Perraud A.-L. , Johnson C.O. , Inabe K. , Smith M.K. , Penner R. , Kurosaki T. , Fleig A. , Scharenberg A.M.
Cell114:191-200(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-1648 AND GLY-1799
7.

"Phosphorylation of annexin I by TRPM7 channel-kinase."
Dorovkov M.V. , Ryazanov A.G.
J. Biol. Chem.279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia."
Chubanov V. , Waldegger S. , Mederos y Schnitzler M. , Vitzthum H. , Sassen M.C. , Seyberth H.W. , Konrad M. , Gudermann T.
Proc. Natl. Acad. Sci. U.S.A.101:2894-2899(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPM6
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1477;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis."
Cai Z. , Jitkaew S. , Zhao J. , Chiang H.C. , Choksi S. , Liu J. , Ward Y. , Wu L.G. , Liu Z.G.
Nat. Cell Biol.16:55-65(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders."
Hermosura M.C. , Nayakanti H. , Dorovkov M.V. , Calderon F.R. , Ryazanov A.G. , Haymer D.S. , Garruto R.M.
Proc. Natl. Acad. Sci. U.S.A.102:11510-11515(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-1482;CHARACTERIZATION OF VARIANT ILE-1482
14.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-68; CYS-406; THR-459; ASN-574; SER-720; VAL-830; TYR-949; ARG-1064; THR-1211; VAL-1254; GLU-1306; LYS-1444 AND ILE-1482

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